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干细胞可能治愈的10种疾病 [复制链接]

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楼主
发表于 2011-6-20 23:42 |只看该作者 |倒序浏览 |打印
本帖最后由 sunsong7 于 2011-6-20 23:49 编辑 " j8 i+ J2 }8 f  e, T) g8 ^

' s" J: J) R3 w9 s* gStem Cells 10 Diseases They May or May Not Cure
/ O& Z1 X+ F  c9 B( ?1 H) QJanuary 21, 2011 by Filed under Stem cell information; N) J7 c' Q/ r- b5 @
来源:http://stemcellumbilicalcordbloo ... ay-or-may-not-cure/
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" L+ _# C- U/ T1 G! |6 L0 jWith President Obama’s recent lifting of the ban on federal funding for embryonic stem cell research, scientists now have new prospects for developing medical treatments. Excitement over the embryonic cells comes from their remarkable ability, as biological blank slates, to become virtually any of the body’s cell types. Many observers believe the president’s move will accelerate the hunt for cures for some of our most vexing diseases. However, the benefits are largely hypothetical, given the infancy of the field, and are offset by some real obstacles: The risks of embryonic stem cells, as well as cells programmed to become like them, include the possibility they will actually cause cancers in people who receive them. Nonetheless, here’s a look at 10 health problems that stem cells might someday cure—or at least help treat:1 Q6 l' G9 W! I) ~0 i! V% w

: ~3 t- v" M, m1. Spinal cord injury(脊髓损伤). In January, the Food and Drug Administration OK’d its first-ever human study of a medical treatment derived from human embryonic stem cells. The objective: help people with acute spinal cord injuries. While expected to assess only the safety of the treatment, the study also might show if the paralyzed volunteers can regain some feeling in and control over their lower extremities.
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2. Diabetes(糖尿病). For the many Americans with type 1 diabetes, whose insulin-making pancreatic cells have been killed off by their immune system, stem cells may be the answer. Last year, scientists reported that they had coaxed human embryonic stem cells into becoming insulin-producing, blood sugar-regulating cells in diabetic mice. The aim: to someday do the same for people.0 V8 |4 b7 X1 Z- u) T' M3 z/ t
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3. Heart disease(心脏疾病). It’s the leading cause of death in the United States, and stem cells may provide some relief. Research is underway to see if injecting the cells into the heart could help regenerate heart muscle damaged by, for example, a heart attack. Again, researchers have reported success in rodents.+ |" d9 d/ t' Y

3 Z+ {6 D! A' i) K* u$ d4. Parkinson’s disease(帕金森综合症). Stem cells may also help those who suffer from Parkinson’s, a neurodegenerative disorder that can cause tremors, stiffness, and other movement and speech problems. Studies show that embryonic stem cells can give rise to the dopamine-making neurons that Parkinson’s patients lack. When transplanted into rodents with a Parkinson’s-like disorder, those replacement brain cells improved the animals’ motor function.
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, b9 \* \/ p$ ^% H7 @7 V" o5. Alzheimer’s disease(老年痴呆症). Likewise, embryonic stem cells may come in handy against Alzheimer’s disease, a progressive and deadly disorder that degrades and kills brain cells, leading to memory loss, cognitive decline, and behavioral problems. Stem cells may give rise to new treatments or even, some say, a cure; other experts have expressed skepticism.
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& y: _9 b! i5 Q. z4 W- |6. Lou Gehrig’s disease(肌肉萎缩性侧索硬化症). There’s hope that stem cells could help those with Lou Gehrig’s disease, also known as amyotrophic lateral sclerosis, or ALS. The crippling disease comes with a grim prognosis: Many die within three to five years of diagnosis, as their bodies progressively damage muscle-controlling motor neurons in the brain and spinal cord. Scientists are exploring ways to coax stem cells into becoming motor neurons that could be transplanted into ALS patients, restoring their ability to move.
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7 b, D4 k! f6 Z3 O4 o7. Lung diseases(肺脏疾病). From human embryonic stem cells, researchers in Texas have created transplantable sources of lung cells in the lab. Those lung cells could potentially be used to repair damage brought on by a variety of pulmonary conditions or by lung trauma resulting from a car accident, bullet wound, or sports injury. Unpublished studies using such cells have shown promise for tissue repair in mice with acute lung injury, the group reports.2 t9 Y) H. V( A6 T1 E
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8. Arthritis(关节炎). Also called degenerative joint disease, osteoarthritis—the most common form of arthritis—results when protective cartilage in joints wastes away. Once it’s gone, it’s gone for good. Stem cells could change that. Scientists are examining how best to use them to rebuild lost cartilage and repair shot joints., m5 {* b) `) \) z

, _  l- S- k( C5 i9 W9. Sickle cell anemia(镰状细胞性贫血). Stem cell researchers are exploring ways to correct numerous blood disorders, including sickle cell anemia. Mice have been cured of the sometimes-deadly condition after receiving transfusions of stem cells made from their own skin cells.$ O- ?: B9 ^7 |+ ]

( d7 ^* z2 Z$ x, ?  j5 h10. Organ failure(器官失能). What better way to ease the shortage of organs for transplantation than to grow new ones? That’s what some scientists think, and with stem cells, that vision may become more than a pipe dream. Last year, researchers grew a beating rat heart in the lab with the help of heart cells from newborn rats, preliminary proof of the concept.2 h- O0 Y+ V" q" e& Z& @  E- t

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沙发
发表于 2011-6-21 01:32 |只看该作者
木有脑瘫

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藤椅
发表于 2011-6-22 10:57 |只看该作者
1. Spinal cord injury(脊髓损伤). 神经细胞和胶质细胞的修复和再生) A; E  |" w6 C' t* T( A. S, W
2. Diabetes(糖尿病). 胰岛B细胞和胰腺细胞的再生
2 J/ r  t$ z+ v* ?( j; Q3. Heart disease(心脏疾病). 心肌细胞和血管平滑肌细胞
0 W: k3 A' }! ]/ h2 N4. Parkinson’s disease(帕金森综合症). 神经内分泌核团细胞
7 [5 n. l0 w3 t) b9 T' W/ i* ?" e7 B5. Alzheimer’s disease(老年痴呆症).大脑皮层和皮层下神经元细胞 - Y  `2 V" L" \* B' q' i) y
6. Lou Gehrig’s disease(肌肉萎缩性侧索硬化症).神经-肌肉触点细胞
8 P4 B4 n4 ^5 S4 O4 j$ @. z' D1 v/ j7. Lung diseases(肺脏疾病). 肺泡和血管平滑肌细胞
6 m2 J8 L# x& \0 u6 Z! w8. Arthritis(关节炎). 关节软骨和成骨细胞2 u# W( r' d* ~- I1 |
9. Sickle cell anemia(镰状细胞性贫血). 骨髓和红细胞
: J" N5 i/ @* ?9 ~- u; z: q10. Organ failure(器官失能). 细胞层面抗衰老和老化
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疾病治疗方面提到了心脑肺胰四个器官; 肌骨血三大组织;没有提肝脏、肾脏;不知道是有难度还是为了避开器官移植的冲击;
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保健方面提到了器官失能,没有强调主要器官,说明对所有器官的细胞失能有效,片面证明了细胞再生抗衰老的应用合理性;
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; ]- d! J7 j3 \- R2 X5 O( O. Q没有提到免疫系统或者免疫细胞方面的问题,是不是说,干细胞治疗白血病绝对有效,以作和“可能有效、可能治愈”相区别。
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板凳
发表于 2011-6-25 16:28 |只看该作者
干细胞之家微信公众号
为什么那家仍然忽略关注解决ips植入体内产生的免疫反应上,而仍然在畅想ips的伟大前景?免疫排斥都没有解决,谈下面的会不会有点不切实际呢?
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报纸
发表于 2011-6-26 18:22 |只看该作者
我觉得干细胞未来最切实际,以及最开始的应用可能在这样的病例上:
/ a0 v+ V, [0 W! }7 B( i/ E1. 终末型疾病,也就是说,病人如果在不进行干细胞治疗,短期生存率极低的终末性疾病。也就是我们理念上的“死马当作活马医”。举个例子,如肝衰终末期病人,假如已知生存的希望不大,就可以尝试使用一下转分化的干细胞(比如最近中科院上海发的那篇NATURE中的细胞),这样,即使细胞可能会有一定的缺陷,但是在那种情况已经坏的不能再坏的前提下,是否可以暂时忽略呢?5 T8 g! ^; s: K8 E6 I% @
2. 另外就是完全没有生存质量的疾病。如脊髓损伤,老年痴呆症,脑瘫等,像脊髓损伤导致的植物人,可以在干细胞治疗上更加激进一点,这样即使可能有一些不好的情况出现,在伦理上也是得到患者家属支持的,知情同意一定要做好。
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地板
发表于 2011-6-27 01:17 |只看该作者
同意群友的见解,干细胞治疗疾病目前仍然处于探索阶段,目前临床上公认的治疗损伤和衰竭器官或者组织的方法仍然是器官移植(包括骨髓移植)。干细胞理论还需要进一步完善,许多技术环节还需要进一步规范,冒然进入临床领域后果严重。
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