Low-risk reprogramming

huangcong1988

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' g' \& s- M5 }- e$ C" @, M09年的文章，评论性质的6 v- h# M# D, o( h
主要讲如何降低ips的致癌风险
: l/ J  v: h) K, G3 ~从Yamanaka用4个诱导因子诱导出ips以来，对于提高ips效率和降低致癌风险的报道就没断过，这篇文章是今天无意看到的，其实两页，没写什么实质性的东西，只是里面提到了很多现在看来还是很有道理的东西，如下是文章的结尾段：It remains to be seen whether alternative reprogramming methods currently under development — such as reprogramming by simply exposing differentiated cells to small molecules, either alone or in combination with gene introduction — will prove more efficient than the techniques described so far. And crucial questions about the equivalency of human iPS cells to embryonic-stem-cell lines remain: do these cell lines have the same developmental capacity as embryonic stem cells, and will they prove to be stable genetically and epigenetically? Rapid progress in this exciting field hints that the answers to these questions will soon become clear.（官话可以忽略）  虽然文章主要是评论另外一篇文章，但最后这一段的几个问题还是提得很好，值得思考