病人自己的肾细胞也许能治肾病

sunsong7

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来自澳大利亚莫纳什大学和中科院广州所消息，取自病人的肾细胞可以被重编程为祖细胞，用于生成任何类型的成熟肾细胞，这项研究对肾病患者具有治疗性意义，并可能用于肾病药物的筛选。文章发表在《American Society Nephrology (JASN)》7 ?: q- a7 a0 k
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来源：Genetics & Stem Cells News 4 `; y, Y9 J0 z' ^9 s$ b) P( L
Kidney Diseases may be Cured by Patients' Own Kidney Cells
5 O2 a7 {' k1 f; Nby Kathy Jones on  July 29, 2011 at 9:18 PM , g5 V6 ?. r  c3 k# ~+ ~
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It is reported that scientists have found that patients' own kidney cells can be reprogrammed and used as a therapy against kidney disease. 6 a7 Q4 v  C! y! [& w! e* V
Reprogramming patients' kidney cells could mean that in the future, fewer patients with kidney disease would require complicated, expensive procedures that affect their quality of life.
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In the first study, Sharon Ricardo, PhD (Monash University, in Clayton, Australia) and her colleagues took cells from an individual's kidney and coaxed them to become progenitor cells, allowing the immature cells to form any type in the kidney.
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4 D4 r" T  B1 w: G6 }' QSpecifically, they inserted several key reprogramming genes into the renal cells that made them capable of forming other cells. ( i, H. J0 n# F0 v4 ]6 `

' W4 \1 i- w4 C2 _& h% kIn the second study, Miguel Esteban, MD, PhD (Chinese Academy of Sciences, in Guangzhou, China) and his colleagues found that kidney cells collected from a patient's urine could also be reprogrammed in this way. 2 B  j6 H- j0 l! L

  P1 @; J( w0 m) u4 C4 i4 w3 O* gIf researchers can expand the reprogrammed cells-called induced pluripotent stem cells (iPSCs)-and return them to the patient, these IPSCs may restore the health and vitality of the kidneys.
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In addition to providing a potentially curative therapy for patients, the breakthroughs might also help investigators to study the causes of kidney disease and to screen new drugs that could be used to treat them.
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) F! D9 Z5 W7 R" tThe study was published in the Journal of the American Society Nephrology (JASN).
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Read more: Kidney Diseases may be Cured by Patients' Own Kidney Cells | MedIndia http://www.medindia.net/news/Kid ... 1.htm#ixzz1TbYGJbiZ

托斯卡纳教父

谁有全文？发个上来啊

lele

肾细胞通过重编程转分化为IPS，进而应用于临床，在临床应用上具有重要的意义。不知道目前都有哪些这样的成熟体细胞重编程为IPS的？有没有进一步临床应用的文章？请教各位大虾

sxhwf

先是肺部发现了能分化为各种肺细胞的肺干细胞，然后肾脏更进一步，可以把肾细胞转化为能分化为各种肾细胞的肾干细胞，也许寻找器官干细胞是器官再生的一个新方向哦，期待

sxhwf

先是肺部发现了能分化为各种肺细胞的肺干细胞，然后肾脏更进一步，可以把肾细胞转化为能分化为各种肾细胞的肾干细胞，也许寻找器官干细胞是器官再生的一个新方向哦，期待