日本研究人员揭开运动使大脑重返年轻的奥秘（附原文）

细胞海洋

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新华社东京8月11日电日本产业技术综合研究所近日发表公报说，运动可以刺激脑细胞合成一种名为Ｗｎｔ3的蛋白质，而这种蛋白质能帮助大脑重返年轻。/ P8 B1 j. g+ q4 R3 e3 u1 M

9 u1 r: s* w) C+ k( R, a　　公报说，大脑内掌管学习和记忆的海马区内有神经干细胞。人成年后，神经干细胞仍然能够不断产生新的神经细胞，保证海马区的神经细胞持续更新。不过，人步入老年后，海马区神经干细胞的细胞制造能力会逐渐减弱，大脑的各项功能也随之下降。: I3 X! w2 B3 @0 B( E; Z+ _; C

& D: h7 J9 @" ]& C　　产业技术综合研究所的科研人员对比了年老实验鼠和年轻实验鼠在大脑海马区的星形胶质细胞的差异。星形胶质细胞是脑内神经胶质细胞的一种。
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　　科研人员发现，年老实验鼠的星形胶质细胞生成蛋白质Ｗｎｔ3的能力明显下降，只有年轻实验鼠的约三十分之一。科研人员猜测，Ｗｎｔ3不足，可能就是大脑神经干细胞功能下降的原因。" T6 s, B: T% q( N- u. _0 v

7 M7 R9 I. X7 r5 ^' d1 m& r) @+ U　　在进一步的实验中，科研人员让年老实验鼠短时间跑步。锻炼后，实验鼠大脑产生Ｗｎｔ3蛋白质的能力有了大幅度的提高。随之，大脑神经干细胞的活动也活跃起来。科研人员说，如果坚持锻炼，大脑就会重返年轻。
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3 a6 g$ ^5 H; g7 a; i　　此次成果的论文将刊登于即将出版的《美国实验生物学联合会会志》上。
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6楼原文 感谢麻团 提供

runsong

要跑跑步了。

towersimper

回复 细胞海洋 的帖子
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Reduction in paracrine Wnt3 factors during aging causes impaired adult neurogenesis
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3 K0 Y9 K$ d- K( i- H  L4 }- jMasahiro Okamoto, Koshiro Inoue, Hiroki Iwamura, Kazuyuki Terashima, Hideaki Soya, Makoto Asashima and Tomoko Kuwabara
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The mammalian brain contains neural stem cells (NSCs) that enable continued neurogenesis throughout adulthood. However, NSC function and/or numbers decline with increasing age. Adult hippocampal neurogenesis is unique in that astrocytes secreting Wnt3 promote NSC differentiation in a paracrine manner. Here, we show that both the levels of Wnt3 protein and the number of Wnt3-secreting astrocytes influence the impairment of adult neurogenesis during aging. The age-associated reduction in Wnt3 levels affects the regulation of target genes, such as NeuroD1 and retrotransposon L1, as well as the expression of Dcx, which is located adjacent to the L1 loci. Interestingly, the decline in the extrinsic Wnt3 levels and in the intracellular expression of the target genes with aging was reversible. Exercise was found to significantly increase de novo expression of Wnt3 and thereby rescue impaired neurogenesis in aged animals. Furthermore, the chromatin state of NeuroD1, L1, and the L1 loci near Dcx changed relative to Wnt3 levels in an age- or stimulus-associated manner. These results suggest that the regulation of paracrine factors plays a critical role in hippocampal aging and neurogenesis.- q$ V( \% \7 k1 n! p

& N. m& I2 \/ E; {; Z4 u/ F; LThe FASEB Journal, Published online before print July 11, 2011, doi:10.1096/fj.11-184697fj.11-184697, http://www.fasebj.org/content/ea ... .11-184697.full.pdf" m) ?: a  N' f- h( E

8 L8 a& i3 y: w  m  |可惜不能下载。

麻团

是作用于Wnt通路的Wnt3吗？

haitang_clara

每天跑多少会比较合适呢，呵呵

麻团

找到全文了

jn808

多谢分享！

stenie

摘录：科研人员说，如果坚持锻炼，大脑就会重返年轻。
; Z1 x, i! J) \. B不错不错。。