前列腺癌症疗法新突破New Treatment Option for Advanced Prostate Cancer

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6 r( N! e/ f7 R; G# X    Prostate cancer that has become resistant to hormone treatment and that does not respond to radiation or chemotherapy requires new methods of treatment. By attacking stem cell-like cells in prostate cancer, researchers at Lund University are working on a project to develop a new treatment option./ k+ K; G5 J8 ^* o) w
    An interdisciplinary project is underway between two research groups, in which senior researcher Rebecka Hellsten and Professor Anders Bjartell at the Faculty of Medicine's division for Urological Cancer Research, Skåne University Hospital in Malmö, and Professor Olov Sterner and Assistant Professor Martin Johansson at the Lund University division of Organic Chemistry recently published their latest research findings in the scientific online journal PLoS ONE.. e& W2 F8 p0 k# A8 X' I. k0 Q
    "Prostatic tumours are thought to consist only of about 0.1 per cent cancer stem cells, but if you are not successful in eradicating that tumour cell population, there is a risk of subsequent uncontrolled growth of the tumour. The cancer stem cells are often unresponsive to both hormonal treatment and to chemotherapy, so it is essential to develop a direct treatment towards all types of cancer cells," says Anders Bjartell.
3 V* z" }0 f$ v/ g% s/ p1 W    Exploring the tumour biology of prostate cancer, the research group have now observed that the protein STAT3 is active in the stem cell-like cells. In their previous studies, they have proven that the natural compound galiellalactone affects STAT3 and has inhibitory effects on the growth of prostate cancer.
9 P/ D2 k/ M( F& Y6 ^* B$ g    Through the development of new specific STAT3-inhibitors with galiellalactone as a model, the researchers hope to develop targeted therapies that attack the stem cell-like cancer cells in prostate cancer and prevent the tumour from growing and spreading

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两个大学的研究小组正在进行跨学科的合作，对于激素治疗耐药且对放疗和化疗无效的前列腺癌，采用新的治疗方法--攻击前列腺癌中的干细胞样细胞。（最新的研究成果发表于科学在线版PLoS ONE）' J2 `& l2 u  E

5 ]2 B# [$ n  L/ q/ v研究员Anders Bjatell谈到，“通常认为前列腺癌仅存在0.1%的肿瘤干细胞，但是如果未成功清除这些细胞，它们就有疯长的危险。肿瘤干细胞通常对激素治疗、化疗无效，因此，急需建立一种直接治疗所有肿瘤细胞的方法。”* S$ p- m$ d" ?* W( d' S! V# r3 C

! z; s3 N# F$ ~5 e- u  z! A( t研究小组通过研究前列腺癌的肿瘤生物学发现，在干细胞样细胞中，STAT3蛋白活化；在他们早先的研究中，他们证实天然化合物galiellalactone作用于STAT3并且可抑制前列腺癌的生长。' c3 R8 w, O: |9 {) w0 H  ]8 P
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以研发结合galiellalactone的新特异性STAT3抑制剂为模型，研究者希望在前列腺癌方面建立攻击干细胞样肿瘤细胞的靶向治疗，预防肿瘤的增殖和播散。5 D6 o8 h* g- F& M8 o
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Prostate cancer that has become resistant to hormone treatment and that does not respond to radiation or chemotherapy requires new methods of treatment. By attacking stem cell-like cells in prostate cancer, researchers at Lund University are working on a project to develop a new treatment option.
: M* O3 k) V0 I" U; B( s+ ?$ E需要采用新的治疗方法治疗激素治疗耐药且对放疗和化疗无效的前列腺癌。Lund大学的研究者正在研究一种新的治疗方法-攻击前列腺癌中的干细胞样细胞。# U6 p3 W) C) l) H; a# P

* K0 [% P6 r+ I0 {0 N7 F8 E    An interdisciplinary project is underway between two research groups, in which senior researcher Rebecka Hellsten and Professor Anders Bjartell at the Faculty of Medicine's division for Urological Cancer Research, Skåne University Hospital in Malmö, and Professor Olov Sterner and Assistant Professor Martin Johansson at the Lund University division of Organic Chemistry recently published their latest research findings in the scientific online journal PLoS ONE.
9 h" f: w* R- P* Y) h两个大学的研究小组正在进行跨学科的合作，他们最新的研究成果发表于科学在线版PLoS ONE。" r$ f/ u3 ~7 G# h

4 A4 E. }  n2 V% R$ Y    "Prostatic tumours are thought to consist only of about 0.1 per cent cancer stem cells, but if you are not successful in eradicating that tumour cell population, there is a risk of subsequent uncontrolled growth of the tumour. The cancer stem cells are often unresponsive to both hormonal treatment and to chemotherapy, so it is essential to develop a direct treatment towards all types of cancer cells," says Anders Bjartell.+ 0 u' D4 q0 i4 |
Anders Bjatell谈到，“通常认为前列腺癌中存在仅0.1%的肿瘤干细胞，但是如果未成功清除这些细胞，它们就有疯长的危险。肿瘤干细胞通常对激素治疗、化疗无效，因此继续建立一种直接治疗所有肿瘤细胞的方法。”5 D# x8 H. \4 }9 ^2 r; E

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% W! W4 K6 s6 _8 I9 u0 t  {  r, A    Exploring the tumour biology of prostate cancer, the research group have now observed that the protein STAT3 is active in the stem cell-like cells. In their previous studies, they have proven that the natural compound galiellalactone affects STAT3 and has inhibitory effects on the growth of prostate cancer.)
- R$ F. I3 R) u5 O, Q研究小组通过研究前列腺癌的肿瘤生物学发现，在干细胞样细胞中STAT3蛋白活化；在他们早先的研究中，其正式天然化合物galiellalactone作用于STAT3并且可抑制前列腺癌的生长。
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    Through the development of new specific STAT3-inhibitors with galiellalactone as a model, the researchers hope to develop targeted therapies that attack the stem cell-like cancer cells in prostate cancer and prevent the tumour from growing and spreading" `6 k; a+ ^  n1 ^& n
以研发结合galiellalactone的新特异性STAT3抑制剂为模型，研究者希望在前列腺癌方面建立攻击干细胞样肿瘤细胞的靶向治疗，预防肿瘤的增殖和播散。: J# ~. B0 G7 H* _: S. G