PDF电子书《Therapeutic Monoclonal Antibodies: From Bench to Clinic》

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! ~# W: r5 j' b; Q8 |* W' bZhiqiang An, "Therapeutic Monoclonal Antibodies: From Bench to Clinic"  2 a+ q! U" Q- G+ r
Wiley | 2009 | ISBN: 0470117915 | 905 pages | PDF | 11,4 MB   
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+ K, N+ G# f. W7 ?8 v+ V70-chapter authoritative reference that covers therapeutic monoclonal antibody discovery, development, and clinical applications while incorporating principles, experimental data, and methodologies.
5 w( m3 m# i% c, T& DFirst book to address the discovery and development of antibody therapeutics in their entirety.
; `6 }# @  t8 c* `; ^6 dMost chapters contain experimental data to illustrate the principles described in them.
6 t3 `- y7 v+ c: Q* cAuthors provide detailed methodologies that readers can take away with them and use in their own laboratories( _0 V6 {3 s2 Z: B0 L
2010-7-12 18:23:52 上传下载附件 (32.22 KB) . H' y7 R' w0 s2 `
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THERAPEUTIC MONOCLONAL ANTIBODIES    -146 d3 G9 d" w0 }+ m7 m* E
    CONTENTS    -12
' w( c4 L% C, f/ z( L    FOREWORD    -8# E6 L6 U. X2 i: o
    PREFACE    -6
0 |+ T; d6 w7 |, m$ ~9 _  D$ S    CONTRIBUTORS    -4! l) P6 q6 S8 s0 }
    PART I ANTIBODY BASICS    1  a3 z) F; z8 d- j+ {
        1. Therapeutic Monoclonal Antibodies: Past, Present, and Future    30 F4 q' q# i$ n7 [, t. C
        2. Antibody Molecular Structure    51/ C8 o7 ~+ T# v7 A6 [( C2 v
        3. Glycosylation of Therapeutic IgGs    67: U9 \$ n% ~: E8 O" s8 `
        4. Antibody Databases and Tools: The IMGT(? Experience    913 _  A$ W1 V0 ?; {' H: ^
    PART II ANTIBODY SOURCES    115& s/ r" Z! {2 [0 O* i% E' `
        5. Human Antibodies from Transgenic Mice    117
" R! p& @6 U  }5 I( g4 b        6. Rabbit Hybridoma    151
3 Z+ r/ D+ A' j8 `7 m8 u) Q  ^        7. Human Antibody Repertoire Libraries    169# Z4 P* q5 K$ Q/ y1 E: m6 \# d# [, z
    PART III IN VITRO DISPLAY TECHNOLOGY    189
2 M  l' }. v& W; R) U        8. Antibody Phage Display    191
# V5 |/ o4 w% h+ t' G- n        9. Yeast Surface Display    213
% v4 M2 d8 B6 e' D# M3 W        10. Ribosomal Display    2394 ^( E! ]6 Z# C) Q4 W0 a$ Z$ B
        11. Bacterial Display of Antibodies    255
$ l: f" r6 a4 e; G' L        12. Antibody Selection from Immunoglobulin Libraries Expressed in Mammalian Cells    2835 f$ |: h  d- J/ j3 K6 f4 r
    PART IV ANTIBODY ENGINEERING    309% g  ?/ V0 U! o4 D
        13. Antibody Engineering: Humanization, Affinity Maturation, and Selection Techniques    311( H1 Y) t$ B% S: F' w7 }* x
        14. Modulation of Serum Protein Homeostasis and Transcytosis by the Neonatal Fc Receptor    335. d0 z" u5 f( v5 A
        15. Engineering the Antibody Fc Region for Optimal Effector Function    349
% d* L5 F& {- F( r8 J    PART V PHYSIOLOGY AND IN VIVO BIOLOGY    371# W: [9 v5 {3 ~
        16. Antibody-Complement Interaction    373( B& n- w" t* [0 d5 {
        17. Bacteria Immunoglobulin-Binding Proteins: Biology and Practical Applications    385
! U9 C+ k) S6 r' ~/ M" X+ S/ r        18. Immunogenicity Screening Using in Silico Methods: Correlation between T-Cell Epitope Content and Clinical Immunogenicity of Monoclonal Antibodies    417
  A, X, a+ }' {1 W  |        19. Monoclonal Antibody Pharmacokinetics and Pharmacodynamics    439) b) G6 o$ {/ d1 {$ @5 O
        20. Biodistribution and Imaging    461
; O# [: A( V6 g# W, w        21. Antibodies and the Blood-Brain Barrier    483
5 ^6 ^* b2 j: m/ z3 v( [    PART VI ANTIBODY CHARACTERIZATION    503% p6 G# Q$ l1 p% i) Q
        22. Determination of Equilibrium Dissociation Constants    505" F' }' t% f  h* n3 b: L- `
        23. Molecular and Functional Characterization of Monoclonal Antibodies    525
+ e+ }, x4 k* c* F. _        24. Characterization of Heterogeneity in Monoclonal Antibody Products    541- ^7 e% @1 |0 |. l- ]% B' P: e& J
    PART VII ANTIBODY EXPRESSION    555- l, ~1 A6 Q% g) Z+ z$ N- M
        25. Antibody Expression in Mammalian Cells    5572 h! A9 U* Y. @  d. v! m
        26. Production of Antibodies in Pichia pastoris    5730 |9 k8 j4 E9 g
        27. Production of Antibody Fab' Fragments in E. coli    589
  r3 a6 k/ c! h, G        28. Production of Human Therapeutic Monoclonal Antibodies in Chicken Eggs    623- ^# K- p: M5 ~
        29. Production of Antibodies in Plants    651, L6 f! k! j  J' ~  d6 C) C) y
    PART VIII THERAPEUTIC ANTIBODIES    6734 A) p* R! M1 G8 K6 H
        30. The Formulation and Delivery of Monoclonal Antibodies    675
) x* H& |" O- @        31. Therapeutic Antibodies in Clinical Use and Leading Clinical Candidates    711
* j5 m) e* H  R% `# `2 J' E6 j; @4 r        32. Follow-On Protein Products: What, Where, When, How?    763; \: h' w& S* Y
        33. Monomeric Fc Fusion Molecules    779  D- \5 f2 W+ r+ I3 k8 p, @1 o
        34. Radioimmunotherapy: Current Status and Future Directions    797
* ]2 Z. R* w. j        35. Antibody-Drug Conjugate Therapy    821: s1 B( U. ~$ Q9 X; P
    ABBREVIATIONS    857
1 U6 p8 U" ]$ \9 f! M9 H    INDEX    865
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