PDF电子书《Therapeutic Monoclonal Antibodies: From Bench to Clinic》

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2 ]* P4 V, K; L- YZhiqiang An, "Therapeutic Monoclonal Antibodies: From Bench to Clinic"  
; |" O9 D6 r& d- S! P9 x0 xWiley | 2009 | ISBN: 0470117915 | 905 pages | PDF | 11,4 MB   
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70-chapter authoritative reference that covers therapeutic monoclonal antibody discovery, development, and clinical applications while incorporating principles, experimental data, and methodologies.
: q, g4 T- X, U  m2 s) SFirst book to address the discovery and development of antibody therapeutics in their entirety.
- c" H  `. T3 d. D6 z( XMost chapters contain experimental data to illustrate the principles described in them.2 y" g& t% b% _+ ^" `5 r
Authors provide detailed methodologies that readers can take away with them and use in their own laboratories/ g( ~9 \6 y; K4 s, p; {
2010-7-12 18:23:52 上传下载附件 (32.22 KB)
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5 R8 u$ x* I. A. }: W: \/ f6 r0 P  k# xTHERAPEUTIC MONOCLONAL ANTIBODIES    -147 F- w! Y7 B. S& Q
    CONTENTS    -12
- L+ Z3 f: f( B  w    FOREWORD    -8, @+ \$ S: J3 F  u- _1 n4 h  T
    PREFACE    -6
. ]0 c3 i3 P& L. _( Q- R% V    CONTRIBUTORS    -4
, O& K/ A3 B: |/ N% l7 k    PART I ANTIBODY BASICS    1: ~4 s! g. d8 a' X4 s8 N
        1. Therapeutic Monoclonal Antibodies: Past, Present, and Future    3
: W- Q9 B% F# ^! R( V  T4 b        2. Antibody Molecular Structure    51
+ G/ Y  u- v8 Q, A  ?1 `. r        3. Glycosylation of Therapeutic IgGs    67
5 d7 k# D' `8 ]+ S8 U0 I        4. Antibody Databases and Tools: The IMGT(? Experience    914 e0 x7 n0 |3 C' V
    PART II ANTIBODY SOURCES    115' L0 I; z1 t$ U- d- K/ q
        5. Human Antibodies from Transgenic Mice    117
+ }( v: S7 s% N        6. Rabbit Hybridoma    151
8 b% q- C3 S& M; a        7. Human Antibody Repertoire Libraries    169
2 w* G3 m2 H0 J, S1 _8 _    PART III IN VITRO DISPLAY TECHNOLOGY    189
6 `" }. x7 O( w) ]# V6 d6 c        8. Antibody Phage Display    1910 J4 v" z: N; p: ~: o. d. |
        9. Yeast Surface Display    213- w6 l7 S5 P$ G& J4 p
        10. Ribosomal Display    239
* a3 ^. P0 k8 W, v' A2 r! k6 M! p        11. Bacterial Display of Antibodies    255
# M4 N; L( c& B& d( m2 p6 l        12. Antibody Selection from Immunoglobulin Libraries Expressed in Mammalian Cells    283
- Y% }) n2 ~$ k& a    PART IV ANTIBODY ENGINEERING    309' J; g( d0 e# n8 Z4 `. ?
        13. Antibody Engineering: Humanization, Affinity Maturation, and Selection Techniques    311% t& h3 Y, B3 P9 V4 ?0 x
        14. Modulation of Serum Protein Homeostasis and Transcytosis by the Neonatal Fc Receptor    335% K+ z" k. G: n% m7 o
        15. Engineering the Antibody Fc Region for Optimal Effector Function    349
7 L$ O& w& w3 U3 o; _    PART V PHYSIOLOGY AND IN VIVO BIOLOGY    371
3 Y* Q( K# ]4 k! u9 \        16. Antibody-Complement Interaction    3736 p0 d3 A# Q- z- Q
        17. Bacteria Immunoglobulin-Binding Proteins: Biology and Practical Applications    385
2 e7 ^" A' F* y, J+ I  `        18. Immunogenicity Screening Using in Silico Methods: Correlation between T-Cell Epitope Content and Clinical Immunogenicity of Monoclonal Antibodies    4179 ~0 B& L% T5 p. h+ s! P
        19. Monoclonal Antibody Pharmacokinetics and Pharmacodynamics    439
6 [+ V/ R) o+ {3 Y9 C2 h3 e        20. Biodistribution and Imaging    461
" Q- _2 u! K$ h        21. Antibodies and the Blood-Brain Barrier    483
7 D) _8 y' Q& r- q+ @    PART VI ANTIBODY CHARACTERIZATION    503
8 Y5 H$ W  N$ c- e  O7 c4 |        22. Determination of Equilibrium Dissociation Constants    505
. B% @; d* h; M0 n9 D        23. Molecular and Functional Characterization of Monoclonal Antibodies    5256 C/ o3 o, L( L' {8 i8 a/ U' P
        24. Characterization of Heterogeneity in Monoclonal Antibody Products    541) W+ ^9 V% f4 K- e& |) E" c
    PART VII ANTIBODY EXPRESSION    555& D0 K- J+ |' C/ G3 I1 ^' u
        25. Antibody Expression in Mammalian Cells    557' m, R! ^" _. w; h" c
        26. Production of Antibodies in Pichia pastoris    5736 c8 @! U2 e- E. y$ n4 I
        27. Production of Antibody Fab' Fragments in E. coli    5891 J. \; {5 F0 j6 Q$ c
        28. Production of Human Therapeutic Monoclonal Antibodies in Chicken Eggs    6237 `; C; c; m# N  I% P% O( Z
        29. Production of Antibodies in Plants    651
4 F; N/ P9 |* ?  e) R    PART VIII THERAPEUTIC ANTIBODIES    673
; C' ?9 r' R; r9 m7 T1 d% N! `        30. The Formulation and Delivery of Monoclonal Antibodies    6752 g& B4 Y- V! D) |/ s" z4 T. y, a# e
        31. Therapeutic Antibodies in Clinical Use and Leading Clinical Candidates    711
+ F  Q" d8 f# x& J        32. Follow-On Protein Products: What, Where, When, How?    763
# h/ A- i; Z8 e) w8 v$ I; W, n0 q        33. Monomeric Fc Fusion Molecules    779
1 x0 f% p* P8 ]! [& S1 e        34. Radioimmunotherapy: Current Status and Future Directions    797; O4 J; n* u' v# M
        35. Antibody-Drug Conjugate Therapy    821
- o& B" d; q9 O    ABBREVIATIONS    857
9 L2 O8 E; d+ a    INDEX    865
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