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1 题目：Mutation-specific effects of polymorphism H558R in SCN5A-related sick sinus syndrome
1 X6 i$ S0 K6 d1 ]+ X文献出处：J Cardiovasc Electrophysiol. 2010 May;21(5):564-73. Epub 2010 Apr 6
3 @) ~8 h% Q F4 K# d作者：Gui J, Wang T, Trump D, Zimmer T, Lei M
7 M5 L/ ?+ a; H! R- i" u: s; y1 m全文链接：http://onlinelibrary.wiley.com/doi/10.1111/j.1540-8167.2010.01762.x/abstract
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% j, q7 a. G3 e; @, Z2 题目：Not so fast! Sick sinus syndrome is a complex and incompletely understood disease that might prove hard to model in animals
1 [: S4 s" U4 A# Q4 ]' S; F5 h" @文献出处：Cardiovasc Res (2011) 92 (1): 178" H6 C1 U) c& D u
作者：Gwilym Matthew Morris 5 j# R+ V( [0 |2 x7 r
全文链接：http://cardiovascres.oxfordjournals.org/content/early/2011/08/16/cvr.cvr204.full.pdf+html
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) |* H5 ~; g4 n" ^3 题目：Phenotypical Manifestations of Mutations in the Genes Encoding Subunits of the Cardiac Sodium Channel % t9 z2 Y% i4 G% X9 C
文献出处：Circulation Research. 2011;108:884-8976 n& ?) ~1 o+ {2 D* E3 ~
作者：Arthur A.M. Wilde, Ramon Brugada & `! T& F' c' h9 ^$ A% Q1 _+ h
全文链接： http://circres.ahajournals.org/content/108/7/884.full: B5 F3 i: T2 h
" K9 Q- T& x( f* Q( B; y$ |' Y4 题目：SCN5A mutations associate with arrhythmic dilated cardiomyopathy and commonly localize to the voltage-sensing mechanism
, @3 |) E M! c( V文献出处： Am Coll Cardiol. 2011 May 24;57(21):2160-8
/ J3 w" j" B! _- e7 }9 ^作者：McNair WP, Sinagra G,
& a d5 P1 a- O/ I全文链接：http://www.sciencedirect.com/science/article/pii/S0735109711008904" n+ \8 y5 f4 ^7 `3 t W
% C0 q: X+ F: ]. _) z5 s5 题目：Sodium channel mutations and arrhythmias' g6 G$ U. t; X
文献出处：Nature Reviews Cardiology 6, 337-348 (May 2009)( ~% @# W G, k- v1 J4 s
作者：Yanfei Ruan, Nian Liu & Silvia G. Priori6 F0 E+ p4 K5 y& z
全文链接http://www.nature.com/nrcardio/journal/v6/n5/full/nrcardio.2009.44.html( d; |% C8 K6 J' E$ @4 ]
% N' s; t3 t; ?1 {* V2 ^6 题目：Striking In Vivo Phenotype of a Disease-Associated Human SCN5A Mutation Producing Minimal Changes in Vitro
9 h) c" J8 w" D( W5 K, W文献出处：Circulation. 2011;CIRCULATIONAHA
0 l' U9 U& ?% L8 C! L6 i作者：Hiroshi Watanabe, MD, PhD, FESC; Tao Yang, PhD;
2 [) I) U# Z: p. }全文链接：http://circ.ahajournals.org/content/early/2011/08/08/CIRCULATIONAHA.110.987248.full.pdf+html- l! y( s; U& F e P. K% b
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7 题目：TGF-β1-mediated fibrosis and ion channel remodeling are key mechanisms in producing the sinus node dysfunction associated with SCN5A deficiency and aging.
/ N& g/ g. o, m8 Z6 a+ ]文献出处：Circ Arrhythm Electrophysiol. 2011;4:397-406,1 m) T& ?! |/ Q; y( g* M
作者：Hao X, Zhang Y, Zhang X,( A+ a& @8 z9 L: v1 \
全文链接：http://circep.ahajournals.org/content/4/3/397.long1 B3 o. q; M# w; `. c8 b
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发表于 2011-11-13 22:41
