求助文献1篇

mreric

1. http://www.sciencedirect.com/science/article/pii/S1535610811003564, }$ a4 ]6 R8 n( e$ R
Cancer Cell. 2011 Nov 15;20(5):576-90.
% E$ X8 \# l0 V3 h$ j9 R' [, W2 ~Direct Signaling between Platelets and Cancer Cells Induces an Epithelial-Mesenchymal-Like Transition and Promotes Metastasis

beyondhl

Direct Signaling between Platelets and Cancer Cells Induces an Epithelial-Mesenchymal-Like Transition and Promotes Metastasis
' Q! s: D' Z: o% O+ P0 w- wMyriam Labelle1, Shahinoor Begum1, Richard O. Hynes1
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) p0 R% l" @( y1        Howard Hughes Medical Institute, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA2 T9 z# m6 `9 ?' n: g8 u
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Summary
* A  Z6 `" f; P* g4 f7 m$ H/ SInteractions of cancer cells with the primary tumor microenvironment are important determinants of cancer progression toward metastasis but it is unknown whether additional prometastatic signals are provided during the intravascular transit to the site of metastasis. Here, we show that platelet-tumor cell interactions are sufficient to prime tumor cells for subsequent metastasis. Platelet-derived TGFβ and direct platelet-tumor cell contacts synergistically activate the TGFβ/Smad and NF-κB pathways in cancer cells, resulting in their transition to an invasive mesenchymal-like phenotype and enhanced metastasis in vivo. Inhibition of NF-κB signaling in cancer cells or ablation of TGFβ1 expression solely in platelets protects against lung metastasis in vivo. Thus, cancer cells rely on platelet-derived signals outside of the primary tumor for efficient metastasis.' \; x! P! _: u/ \
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mreric

非常感谢！！

郭小妹

我也想求助一篇文献，但发不了贴，路过看到的各位大侠帮个忙啊0 A( T1 [2 O. `( Q- [; t# y
Culture conditions and signalling networks promoting the establishment of cell lines from parthenogenetic and biparental pig embryos.
% G7 @* R' e1 q9 PStem Cell Rev. 2010 Sep;6(3):484-95.
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