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| Caplan et al. (page 109)find evidence that human Vam6 protein is a mammalian tethering or docking factor with the intrinsic ability to promote lysosome fusion in vivo. The protein is related to a member of a vacuole-fusion complex in budding yeast, but has a unique citron homology domain that is required for lysosome clustering and fusion. Although Rab7 can induce lysosome fusion in yeast, dominant-negative Rab7 does not block hVam6p activity, suggesting that the human protein operates either downstream of, or in parallel to Rab7.(Overexpression of human Vam6p (red) prom) |
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发表于 2009-3-5 23:31
发表于 2015-5-30 12:10
