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本帖最后由 细胞海洋 于 2011-12-24 11:20 编辑
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Liver Stem Cells: Methods and Protocols
5 v' ^% e5 M- m" g! G, [- s0 Q1 g, KTakahiro Ochiya, . K+ B, N7 L/ s
Publisher: Humana Press
4 N1 B$ }& f( v9 e* ^) I2012
8 X9 N3 H, c& _9 K) B; cISBN: 1617794678 6 k" @. z# b1 G; L, D
7 T- t9 \. O7 L, @9 m" nIncreasing evidence suggests that liver stem cells have the capacity todifferentiate into parenchymal hepatocytes or into bile ductular cells.These stem cells may be activated to proliferate after severe liverinjury or exposure to hepatocarcinogens. Stem cell replacementstrategies are being investigated as an alternative approach to liverrepair and regeneration. Additionally, stem cell transplantation hasbeen shown to significantly improve liver function and increase survivalin experimentally-induced liver-injury models in animals. In Liver StemCells: Methods and Protocols, expert researchers focus on severalhepatic progenitor cells, hepatic differentiation form stem cells, bileductal cell formation from stem cells, liver stem cells andhepatocarcinogenesi, and application of liver stem cells for celltherapy. These topics shed light on stem cell technology which may leadto the development of effective clinical modalities for human liverdiseases. Written in the highly successful Methods in Molecular Biology™series format, chapters include introductions to their respectivetopics, lists of the necessary materials and reagents, step-by-step,readily reproducible laboratory protocols, and key tips ontroubleshooting and avoiding known pitfalls. Thorough and intuitive,Liver Stem Cells: Methods and Protocols seeks to aid scientists in thefurther study of preclinical and clinical investigations that explorethe therapeutic potential of stem cells in repair of liver injuries. 3 ]3 D1 @7 e0 ~) L9 y! L
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发表于 2011-12-24 10:24
