spchsq 发表于 2012-1-8 10:57  2 g G5 X& g& I4 w3 X6 ~
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Stem cells could hold key to 'stopping ageing' say scientists after trial triples mouse lifespan
; ?( z" C3 A% n- [size=1.4em]Lifespan tripled after injection of cells from young mice
- [size=1.4em]Injection made mice grow bigger and stronger
- [size=1.4em]Effect on ageing-disorder cells even works in lab dish
v% |2 W( [7 A: k V5 [6 [ - [size=1.4em]Could hold key for injections that offer humans 'youthful vigor'( i+ a. F+ V. l3 o; A$ M/ i+ P
" p3 d; E) x VBy Rob Waugh N7 s, e$ i1 s* q2 X% J' [( [3 O
" ^( A' }3 U2 T4 z X+ i: Z% c" uLast updated at 8:24 AM on 4th January 2012- ~8 g. u7 `0 i% i
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3 N5 q# R9 M: T0 V2 N An experiment proved that a single injection of stem cells could make mice live three times as long. Scientists think that studying the proteins within stem cells might hold the key to injections that offer a 'shot of youthful vigour' to human beings : g, ? B/ w. Z% i8 E6 S0 l
[size=1.2em]Stem cells can halt ageing - and even prolong lifespans up to three times, scientists say.
5 E, N9 G0 ]3 @1 J8 ~/ n- g[size=1.2em]An experiment proved that a single injection of stem cells could make mice live three times as long.3 N( \. e' a/ E8 t% O2 z2 r
[size=1.2em]The injection also made the mice grow bigger and stronger. - K5 Q. D! ^& R& Z" x# X+ \2 a
2 m- S: g: i+ E: Z# ~[size=1.2em]Scientists think that studying the proteins within stem cells might hold the key to injections that offer a 'shot of youthful vigour' to human beings.
) ?; _: ]4 E0 u[size=1.2em]The researchers, from the University of Pittsburgh,[size=1.2em]say further research could help us hold off the ageing process altogether. ' q5 R+ F+ w& M2 n/ T" o. S
& ?* T# v5 ], p6 V/ ?[size=1.2em]The effect was even visible on cells in a lab dish where young stem cells were placed next to prematurely ageing cells. - K/ l. e5 X- w. R4 Y8 l S
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[size=1.2em]The sick, ageing cells performed better after being placed next to the healthy ones.
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2 w0 z% U0 Q+ N: m2 M1 ]( P, L8 z$ V2 |[size=1.2em]The U.S. researchers conducted experiments on mice modified to age prematurely, a condition known as progeria.
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6 o& J! Z, X' `, m: f/ G( m[size=1.2em]Progeria also occurs in humans.
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[size=1.2em]Giving these mice shots of stem cells from young, healthy counterparts allowed them to live up to three times longer than those with progeria. `4 T4 d1 \2 d' p! x6 H
! Q2 R/ P! E* V1 s8 N8 E) M) S* H( E[size=1.2em]Their experiment saw them first study the stem cells of the progeria sufferers.& j$ C2 N; p& D+ @
[size=1.2em]The scientists saw there was a difference between the cells in the mice with the ageing disorder - they had fewer, the ones they had regenerated less quickly than ordinary mouse stem cells. * @% K0 W) G3 b& p' p
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[size=1.2em]However, injecting stem cells into 17 day-old mice saw a huge increase in their lifespans - from an average of just 21-28 days to more than 66 days, three times longer than usual.
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[size=1.2em]The modified mice given stem cell shots grew almost as large as their healthy counterparts and grew new blood vessels in their brains and muscles.
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 Stem cells can halt the signs of ageing - and even prolong lifespans up to three times, scientists say. An experiment proved that a single injection of stem cells could make mice live three times as long : q# u5 d5 N/ O+ V) L% M% j
[size=1.2em]'The mice were healthier and lived longer after an injection of stem cells from young, healthy animals,' said Dr Laura Niedernhofer; w9 V8 _9 @# T, Z
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2 H3 P* Y" t& i* k4 s4 n7 _[size=1.2em]Scientists think this is because the healthy stem cells helped correct abnormalities in the cells of the rapidly-ageing mice.
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( Y& a( A8 n& Z* @9 e! K[size=1.2em]Study author Dr Laura Niedernhofer, whose findings were published in journal Nature Communications said: 'Our experiments showed that mice that have progeria, a disorder of premature aging, were healthier and lived longer after an injection of stem cells from young, healthy animals.'
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2 P7 \1 V2 X8 A6 r" X! Q7 e[size=1.2em]'That tells us that stem cell dysfunction is a cause of the changes we see with aging.' She added: 'As the progeria mice age, they lose muscle mass in their hind limbs, hunch over, tremble, and move slowly and awkwardly. 5 f2 r9 T2 w* [8 V3 q( {
$ c9 {7 S9 y. a) s* `[size=1.2em]'Affected mice that got a shot of stem cells just before showing the first signs of ageing were more like normal mice, and they grew almost as large.'
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[size=1.2em]'Closer examination showed new blood vessel growth in the brain and muscle, even though the stem/progenitor cells weren’t detected in those tissues. , ~8 x' d7 t3 i1 s0 w0 d4 w2 ^
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[size=1.2em]'In fact, the cells didn’t migrate to any particular tissue after injection into the abdomen. '* O/ v/ k# @) }1 x m4 l9 L
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[size=1.2em]“This leads us to think that healthy cells secrete factors to create an environment that help correct the dysfunction present in the native stem cell population and aged tissue.2 m% @5 t, x! [
[size=1.2em]'In a culture dish experiment, we put young stem cells close to, but not touching, progeria stem cells and the unhealthy cells functionally improved.'
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Read more: http://www.dailymail.co.uk/sciencetech/article-2081734/Stem-cells-hold-key-stopping-ageing-say-scientists-successful-mouse-trial.html#ixzz1iqRTmx7I |
发表于 2012-1-7 22:36
一项研究证实，注入一次干细胞，老鼠的寿命就会延长3倍。科学家认为，研究干细胞里的蛋白质可能是为人类提供“长生不老”注射剂的关键
科学家表示，干细胞可以中断衰老过程，甚至是让寿命延长3倍。一项研究证实，注入一次干细胞，老鼠的寿命就会延长3倍' ? Q5 k& f* |7 e
发表于 2012-1-8 10:57
