What you eat effects your genes

monroelml

南大研究人员发现大米中一种miRNA能够通过消化系统，进入血液循环，结合能够清除LDL的受体蛋白mRNA, 组织其表达，从而导致LDL含量升高。感觉这篇文章还蛮有意思的，跟大家分享一下！) W2 S" T/ q; C- O  m+ e

; B& ~9 u/ m# L4 _+ Q4 NAbstract：
' n7 f+ }$ B/ A7 m# Z$ k; HOur previous studies have demonstrated that stable microRNAs (miRNAs) in mammalian serum and plasma are actively secreted from tissues and cells and can serve as a novel class of biomarkers for diseases, and act as signaling molecules in intercellular communication. Here, we report the surprising finding that exogenous plant miRNAs are present in the sera and tissues of various animals and that these exogenous plant miRNAs are primarily acquired orally, through food intake. MIR168a is abundant in rice and is one of the most highly enriched exogenous plant miRNAs in the sera of Chinese subjects. Functional studies in vitro and in vivo demonstrated that MIR168a could bind to the human/mouse low-density lipoprotein receptor adapter protein 1 (LDLRAP1) mRNA, inhibit LDLRAP1 expression in liver, and consequently decrease LDL removal from mouse plasma. These findings demonstrate that exogenous plant miRNAs in food can regulate the expression of target genes in mammals.

iamxuchen

这篇挺早就发了，在CELL RESEARCH上发的，感觉实验的量和品质都应该不止这点分数，相信这对祖国中草药的进一步发展带来一个巨大的、无限的、充满前景的“坑”....嘿嘿