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Nature Reviews Cancer 5, 65-72 (January 2005) | doi:10.1038/nrc15299 j5 Z4 \2 k- N& X5 \: ]9 F! y4 `9 A
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6 O2 m  e+ X) r" }. i8 @" ?Bruce A. Chabner5 G4 n. ^4 a- ^( x( M1 `$ H1 W! r
Thomas G. Roberts; o8 _2 `3 Q9 d. u+ I0 o7 p5 ?; e0 ~
Chemotherapy and the war on cancer9 l, v- C) }0 A/ Q
Bruce A. Chabner & Thomas G. Roberts1 E2 Z5 F& @: [
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Abstract8 ]  h) }2 s  L9 l6 h. V' D7 R& N
The era of chemotherapy began in the 1940s with the first uses of nitrogen mustards and antifolate drugs. Cancer drug development since then has transformed from a low-budget, government-supported research effort to a high-stakes, multi-billion dollar industry. The targeted-therapy revolution has arrived, but the principles and limitations of chemotherapy discovered by the early researchers still apply. This article chronicles the history of modern chemotherapy and identifies remaining challenges for the next generation of researchers.1 L/ c( w' w0 @" K& u+ c

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