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# w7 l0 {" ~4 w) O( k# xVolume 148, Issue 4
" G' J$ Y0 Y. d s$ E" gOn the cover: Circadian rest:activity rhythms in animals are regulated by endogenous clocks that are typically synchronized to the day:night cycle. In this issue, Luo and Sehgal (pp. 765–779) identify JAK/STAT signaling as a component of the pathway that functions downstream of the clock in the regulation of rest:activity behaviors in Drosophila. They show also that circadian effects of JAK/STAT are modulated by a microRNA, miR-279. The cover image depicts a day:night adapted clock that turns on, or downregulates, JAK/STAT signaling, represented by a “Jack” from a deck of cards. The “Jack” is shown to hold a “sword”—a stem-loop shaped precursor microRNA. Artwork by Lili Guo.0 t. D6 B2 D1 n* v: I3 o! T. ^
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