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; ]/ I/ j' U7 t9 DVolume 148, Issue 4
* R7 O: R8 n) {2 LOn the cover: Circadian rest:activity rhythms in animals are regulated by endogenous clocks that are typically synchronized to the day:night cycle. In this issue, Luo and Sehgal (pp. 765–779) identify JAK/STAT signaling as a component of the pathway that functions downstream of the clock in the regulation of rest:activity behaviors in Drosophila. They show also that circadian effects of JAK/STAT are modulated by a microRNA, miR-279. The cover image depicts a day:night adapted clock that turns on, or downregulates, JAK/STAT signaling, represented by a “Jack” from a deck of cards. The “Jack” is shown to hold a “sword”—a stem-loop shaped precursor microRNA. Artwork by Lili Guo.# P1 V- r5 l; ]7 n- Q
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