胃肠道肿瘤干细胞大牛Hans Clevers

csc1981

研究方向：Wnt signaling and cancer, b7 m' x4 Q. o( G' y4 [; v- i2 ~
TCF factors, mediators of Wnt signaling in development and cancer
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在CNS上发文如灌水一般
& k) o! f3 X% h5 B2 j  l8 Q/ M# N1) van de Wetering, M., Oosterwegel, M., Dooijes, D., and Clevers, H.C. Identification and cloning of TCF-1, a T cell-specific transcription factor containing a sequence-specific HMG box. * E# b4 c% t. a" ~) Q7 B: F/ a& d
EMBO J ., 10:123-132 (1991) / V/ w1 n4 l- Q4 y
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2) Verbeek, J.S., Ison, D., Hofhuis, F., Robanus-Maandag, E., te Riele, H., van de Wetering, M., Oosterwegel, M., Wilson, A., MacDonald, H.R. and Clevers, H.C. An HMG box containing T-cell factor required for thymocyte differentiation.
4 o+ n% J- Q. q/ \Nature 374: 70-74 (1995) ! S. k4 I1 U0 C6 n( X
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3) Schilham, M., Oosterwegel, M., Moerer, P., Jing Ya, de Boer, P., van de Wetering, M., Verbeek, S., S., Lamers, W., Kruisbeek, A., Cumano, A., and Clevers, H .Sox-4 gene is required for cardiac outflow tract formation and pro-B lymphocyte expansion. 4 T4 x. d6 x- t" }5 ?! F- D
Nature , 380: 711-714 (1996) 7 ]* K3 |- |5 v$ |( S, a

1 Z9 m7 b+ ~% P$ s4) Molenaar, M., Van de Wetering, M., Oosterwegel, M., Peterson-Maduro, J., Godsave, S., Korinek, V., Roose, J., Destrée, O. And Clevers, H. Xtcf-3 Transcription factor mediates beta-catenin-induced axis formation in xenopus embryos.
* g, C/ m! d- KCell , 86, 391-399 (1996) . {5 r" @- x' l, z8 ~  h3 d

# t9 G1 B, s# S5) Korinek, V, Barker, N., Morin, P.J., van Wichen, D., de Weger, R., Kinzler, K.W., Vogelstein, B., and Clevers, H. Constitutive Transcriptional Activation by a beta-catenin-Tcf complex in APC -/- Colon Carcinoma. & u; I- x' q# T) u( I# m) a
Science , 275: 1784-1787 (1997) & E1 ?6 x; k4 w* z3 c( o1 K

  ~- m6 ^, I/ e. G, d4 D- v6) Morin, P.J., Sparks, A., Korinek, V., Barker, N., Clevers, H., Vogelstein, B., and Kinzler, K. Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. / d* D/ A9 d! x0 L
Science 275: 1787-1790 (1997) - _$ r( T% f1 ?* A% M

# f* ~3 V) i# H$ n5 m7) Van de Wetering, M., Cavallo, R., Dooijes, D., Van Beest, M., Van Es, J., Loureiro, J., Ypma, A., Hursh, D., Jones, T., Bejsovec, A., Peifer, M., Mortin, M., and Clevers, H. Armadillo co-activates transcription driven by the product of the Drosophila segment polarity gene dTCF .
+ T0 F" ^+ b: f; e  Y/ c# eCell , 88, 789-799 (1997)
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8) Korinek, V., Barker, N., Moerer, P., van Donselaar, E., Huls, G., Peters, P.J. and Clevers, H. Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4. & u/ C0 u+ t9 J) F$ G
Nat Genet 19(4): 379-383 (1998)
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, Z( q: @5 S! w/ b# D: x! z; C' e9) Roose, J., Molenaar, M., Peterson, J., Hurenkamp, J., Brantjes, H., Moerer, P., van de Wetering, M., Destree, O., and Clevers, H. The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors.
; f3 m$ C" j+ P% y0 e* YNature 395(6702): 608-612 (1998) 0 B, R" G! x, K$ F/ n0 S
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10) Roose, J., Huls, G., van Beest, M., Moerer, P., van der Horn, K., Goldschmeding, R., Logtenberg, T., and Clevers, H. Synergie between tumor suppressor APC and the beta-catenin/Tcf4 target gene Tcf1.
3 E: U) }2 S! M' p6 eScience 285: 1923-1926 (1999) 2 }6 U5 R$ }& U6 V9 }6 ?
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11) Korswagen, R., Herman, M. and Clevers, H. Separate beta-catenins mediate Wnt signaling and cadherin adhesion in C. elegans.
1 s" Z; {3 y4 Y1 UNature 406: 527-532 (2000)
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12) Bienz, M., and Clevers, H. Linking colorectal cancer to Wnt signaling. Review
& S: g( Y2 L0 @# v' MCell 103: 311-320 (2000) ) C' w5 @" n+ k* M+ d
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13) Van de Wetering, M., Sancho, E., Verweij, C., de Lau, W., Oving, I., Hurlstone, A., Van der Horn, K., Batlle, E., Coudreuse, D., Haramis, A-P., Tjon-Pon-Fong, M., Moerer, P., Van den Born, M., Soete, G., Pals, S., Eilers, M., Medema, R., Clevers, H. The beta-catenin/TCF4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. 9 I4 b4 t& j2 D3 @/ x1 M
Cell 111: 241-250 (2002) / D. h3 x9 b. M, b, \

3 g4 e/ \1 ]; [$ ?, L14) Battle, E., Henderson, J.T., Beghtel, H., van den Born, M., Sancho, E., Huls, G., Meeldijk, J., Robertson, J., van de Wetering, M., Pawson, T., Clevers, H. Beta- catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB. 5 `# P9 x/ u- O+ Y. r9 U( Y
Cell 111: 251-263 (2002) 6 l6 s7 P7 |" C3 A% V+ M2 M4 f

+ D* b- {8 k( z" ~15) Hurlstone A.F., Haramis A.P., Wienholds E., Begthel H., Korving J., Van Eeden F., Cuppen E., Zivkovic D., Plasterk R.H., Clevers H. , The Wnt/beta-catenin pathway regulates cardiac valve formation.
  Z. \: E7 X8 w6 }7 ^3 L- ^2 L* G$ ]Nature 425:633-7 (2003) + K0 ]+ \: x3 B( z

. z! ]: u$ ^& h+ p, Z16) Baas A.F., Kuipers J., van der Wel N.N., Batlle E., Koerten H.K., Peters P.J., Clevers H.C. , Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD. " G3 X( g1 G/ t* A6 a
Cell. 116:457-66 (2004)
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" k9 k6 m( B9 C9 M17) Haramis A.P., Begthel H., van den Born M., van Es J., Jonkheer S., Offerhaus G.J., Clevers H. , De novo crypt formation and Juvenile Polyposis upon BMP inhibition 0 m% ]- R' U) n
Science. 303:1684-6 (2004) , O* Y" l3 v6 L  B0 \! i
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18) Radtke, F and Clevers, H., Self-renewal and cancer of the gut: Two sides of a coin. Review 2 @+ _' L2 U! @* `
Science. 307:1904-1909 (2005) 3 x( }8 C* E9 ?# [, G9 z2 K

' C! b% m2 C8 m3 e19) Reya T., Clevers H., Wnt signalling in stem cells and cancer. Review
$ a9 l4 L$ W9 M$ SNature 434:843-850 (2005)1 r8 S# [; x5 V* R! t

" O2 q# F, E/ e5 I( y* m- D+ t20) Van Es J.H., Van Gijn M.E., Riccio O., Van den Born M., Vooijs M., Begthel H., Cozijnsen M., Robine S., Winton D.J., Radtke F., Clevers H. Notch pathway/gamma-secretase inhibition turns proliferative cells in intestinal crypts and neoplasia into Goblet cells. 5 ]# `1 K  N% w; X9 C
Nature 435:959-963 (2005) ; n% c- X$ y# A

8 g4 f6 G3 L$ P9 Y# R. a21) Batlle E., Bacani J., Begthel H., Jonkheer S., Gregorieff A., Van de Born M., Malats N., Sancho E., Boon E., Pawson T., Gallinger S., Pals S., Clevers H., EphB activity suppresses colorectal cancer progression , z. L8 z+ w( @( d% a
Nature 435:1126-1130 (2005)
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22) Clevers, H. Wnt/-catenin signaling in development and disease.( m6 I4 T4 J/ S& J4 L3 G: F( F: ^
Cell 127: 469-480 (2006) , d9 ?+ p: c& B6 M4 J3 W/ [

$ L4 R6 B0 d9 W1 K0 J9 O8 B2 S( g23) Barker, N, van Es, J.H., Kuipers, J., Kujala P., van den Born, M., Cozijnsen, M., Korving, J., Begthel, H., Peters, P.C., and Clevers, H. Identification of Stem Cells in Small Intestine and Colon by a Marker Gene LGR5
# v+ C4 O7 l/ m( FNature, 449:1003-1007 (2007)
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24) Jaks V., Barker N., Kasper M., van Es J.H., Snippert H.J., Clevers H., Toftg爀搀 R. Lgr5 marks cycling, yet long-lived, hair follicle stem cells. # H# {: U, [/ N. d* t
Nat Genet. 40 : 1291-1299 (2008)
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4 ]0 K* r. l  ^( A, q3 j4 g25) Barker N., Ridgway R.A., van Es J.H.,van de Wetering M., Begthel H., van den Born M., Danenberg E., Clarke A.R., Sansom O.J., Clevers H. Crypt Stem Cells as the Cells-of-Origin of Intestinal Cancer
1 v. m- {1 u8 p; g, B0 @Nature 457:608-611(2009) ' d% j' P% c+ q( [4 q. g
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26) van der Flier, L.G., van Gijn, M.E., .., and Clevers H. Transcription factor Achaete scute-like 2 (Ascl2) controls intestinal stem cell fate
( Z* Z- n6 Z4 S* I0 e2 eCell 136: 903-12 (2009)/ v5 F/ X: p0 f
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27) Sato, T., Vries, R., Snippert, H., van de Wetering, M., Barker, N., Stange, D., van Es, J., Abo, A., Kujala, P., Peters, P., and Clevers, H. Single lgr5 gut stem cells build crypt-villus structures in vitro without a stromal niche 459(7244):262-5
( `2 \" S+ a. Y$ L1 T7 ~Nature 459 :262-5 (2009) 8 f" j& @6 e) f4 Z2 v; r+ E

, K/ ^9 Y8 J: h) I0 l$ V* L# g28) Barker, N, Huch, M., ..., and Hans Clevers.  Lgr5+ve stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro
- n  |0 s" D( TCell Stem Cell, 6: 25-36 (2010)$ ^) o: n: T- w4 }( |% q  e& i

% D, i" q* q1 P* g2 S29) Snippert, H.J., Haegebarth, A., Kasper, M., Jaks, V., van Es, J.H., Barker, N., van de Wetering,
5 P6 }0 d4 G5 N( \. ]& b& v8 jM., van den Born, M., Begthel, H., Vries, R.G., Stange, D.E., Toftg爀搀, R., Clevers H.  Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin.
8 J; {4 r" ^' \Science 327: 1385-1389 (2010)% n- O* R. l" F3 }( X

( @# X2 k/ b, O/ t/ Z30) Sato, T., van Es, J.H., Snippert, H.J., Stange, D.E., Vries, R.G., van den Born, M., Barker, N., Shroyer, N.F., van de Wetering, M., Clevers, H. Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts.( ?) m! F% ^: X; v* y( L
Nature 469: 415-418 (2010)2 w$ W; u" i. S8 r' Y
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31) Snippert, .J., van der Flier, L.G., Sato, T., van Es, J.H., van den Born, M., Kroon-Veenboer, C., Barker, N.,Klein, A.M., van Rheenen, J. Benjamin D. Simons, B.D. and Clevers, H. Intestinal Crypt Homeostasis results from Neutral Competition between Symmetrically Dividing Lgr5 Stem Cells.
7 k. a  F. Y* h1 G4 m  s: @Cell 143:134-44 (2010)
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32) de Lau, W., Barker, N., ... and Clevers, H. Lgr5 homologues associate with Wnt receptors and mediate R-spondin signaling2 {# n2 t; R- M
Nature 476: 293-297 (2011)
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1 f3 ]4 p* [0 N5 A. w跟踪牛人文献就可以知道这一研究方向的进展% ~7 F/ |8 m8 ^! X  K

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恩 太厉害 了 每年都发这么多SCN  值得学习