《自然》[Nature]12年3月29日出版pdf全文

nero1981

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6 {1 ]+ J/ `/ k/ I7 a7 t+ ICancer cell lines are widely used as preclinical models to gain mechanistic and therapeutic insight. Two manuscripts in this issue describe the large-scale genetic and pharmacological characterization of human cancer cell lines. Each group characterized collections of several-hundred cell lines using different platforms and analytical methods. Their results are complementary, and confirm that many human cell lines capture the genomic diversity of their respective cancers. Initial findings include the identification of a number of potential markers of drug sensitivity and resistance. For example, Garnett et al. report an association between EWS–FLI1 gene translocations, frequently found in Ewing’s sarcoma, and sensitivity to PARP inhibitors, a class of drug currently in clinical trials for other cancer types. Barretina et al. report a possible association between SLFN11 expression and sensitivity to topoisomerase inhibitors. On the cover, dividing fibrosarcoma cells. Cover credit: Steve Gschmeissner/SPL/Corbis
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