韩干细胞治疗恢复四肢瘫痪患者部分知觉（附原文）

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朝鲜日报医学专门记者 金哲中 (2012.05.03 11:08)
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四肢瘫痪患者接受向受损的脊髓移植干细胞的治疗后恢复了部分知觉。他是在8年前的交通事故中因伤到颈部脊椎的中枢神经脊髓而四肢瘫痪。这让因四肢瘫痪而自暴自弃的慢性脊髓损伤患者看到了一线希望。据悉，在韩国因慢性脊髓损伤而四肢瘫痪的患者有5万至6万人。
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首尔峨山医院神经外科教授全相勇（音）率领的小组2日表示：“我们挑选10名在交通事故、坠落事故、暴力事件中因伤到颈部而四肢瘫痪的慢性脊髓损伤患者，向受损的脊髓注射了从患者的骨盆骨髓中抽取的间叶干细胞，结果3名患者的胳膊恢复了部分知觉。”小组称：“核磁共振成像（MRI）也显示，受损的脊髓的伤口减小。”  x2 _. c! W+ Y$ U

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向受损已久的脊髓注射干细胞证明其治疗效果，还是世界医疗史上的首例。该研究成果已被刊登在最新一期美国神经外科学术杂志《神经外科手术（Neurosurgery）》上。
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9 H& ?2 F3 c6 e! e  A8 t接受该手术的朴某1998年在一场交通事故中颈部的脊髓受到损伤。朴某下半身瘫痪，胳膊只能做一些轻微的动作。上半身没有任何知觉。虽然接受了康复治疗，但不见好转。
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, q, a& Q. {8 [8年后的2006年，朴某在首尔峨山医院接受了向损伤的脊髓注入干细胞的手术。一年半后，上半身恢复了知觉，胳膊也有了力气，可以向上张开双臂。
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$ ^7 B1 g$ ?* t; |  d接受该手术的10名患者都是1至8年前在各种事故中因颈部的脊髓受损而出现了神经学后遗症。其中，朴某等3名患者的胳膊恢复了运动功能，可以自己利用辅助器具吃饭。他们可以用自己的力量坐起来，大拇指也有了力气，可以拿着勺子吃饭。& i% D3 F( H" t- K6 z' |, c9 N

5 X$ J* @5 \! ?2 C  ~全相勇说：“即便是受伤很久，只要向脊髓内注射干细胞，就有可能取得神经康复效果。但对有些患者有效果，对有些患者没有效果，下一步我们将查明原因。”5 }" i, J8 T2 U' X4 s; b
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5 Q; s1 v' o8 _1 b- v% v4楼原文 感谢naturalkillerce 提供

naturalkillerce

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Long-term Results of Spinal Cord Injury Therapy Using Mesenchymal Stem Cells Derived From Bone Marrow in Humans! t. G" f2 D, ]2 t0 j' T
Neurosurgery: May 2012 - Volume 70 - Issue 5 - p 1238–1247, doi: 10.1227/NEU.0b013e31824387f9
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Park, Jin Hoon MD*; Kim, Dae Yul MD‡; Sung, Inn Young MD‡; Choi, Gyong Hyo MD‡; Jeon, Min Ho MD‡; Kim, Kwang Kuk MD§; Jeon, Sang Ryong MD*0 o6 z" }3 v' v
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BACKGROUND: Although the transplantation of mesenchymal stem cells (MSCs) after spinal cord injury (SCI) has shown promising results in animals, less is known about the effects of autologous MSCs in human SCI.0 l' p: I. k, `+ I

: c# _( b5 s% v7 Z4 HOBJECTIVE: To describe the long-term results of 10 patients who underwent intramedullary direct MSCs transplantation into injured spinal cords.& V$ R; }7 b# j: b" x
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METHODS: Autologous MSCs were harvested from the iliac bone of each patient and expanded by culturing for 4 weeks. MSCs (8 × 106) were directly injected into the spinal cord, and 4 × 107 cells were injected into the intradural space of 10 patients with American Spinal Injury Association class A or B injury caused by traumatic cervical SCI. After 4 and 8 weeks, an additional 5 × 107 MSCs were injected into each patient through lumbar tapping. Outcome assessments included changes in the motor power grade of the extremities, magnetic resonance imaging, and electrophysiological recordings., J: e3 ~1 d5 E4 }5 \
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RESULTS: Although 6 of the 10 patients showed motor power improvement of the upper extremities at 6-month follow-up, 3 showed gradual improvement in activities of daily living, and changes on magnetic resonance imaging such as decreases in cavity size and the appearance of fiber-like low signal intensity streaks. They also showed electrophysiological improvement. All 10 patients did not experience any permanent complication associated with MSC transplantation.# a! }- Q* h1 p- E' n
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CONCLUSION: Three of the 10 patients with SCI who were directly injected with autologous MSCs showed improvement in the motor power of the upper extremities and in activities of daily living, as well as significant magnetic resonance imaging and electrophysiological changes during long-term follow-up.
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http://journals.lww.com/neurosur ... ury_Therapy.21.aspx

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