Suicide attempt linked to breakdown

杨柳

The Golgi apparatus breaks down temporarily to segregate into daughter cells during mitosis, but during apoptosis the organelle fragments irreversibly. On page 637, Chiu et al. report that cleavage of a critical tethering protein during apoptosis not only drives the fragmentation of the Golgi apparatus, but also appears to help propagate the apoptotic signal. The work adds to mounting evidence that the Golgi apparatus is a perpetrator as well as a victim of apoptosis.
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The authors found that the tethering protein p115, which is essential for maintaining normal Golgi apparatus architecture, is selectively cleaved during apoptosis. The apoptotic proteases caspase-3 and caspase-8 cleave the protein in vitro, and a stable cell line expressing a cleavage-resistant form of p115 exhibits a delay in Golgi fragmentation during apoptosis. Expressing the COOH-terminal cleavage fragment of p115 in cells is sufficient to induce fragmentation, and, surprisingly, this fragment also translocates to the nucleus, where it induces apoptosis. The data suggest that the p115 COOH-terminal fragment serves two functions during apoptosis, both disrupting the Golgi apparatus as a dominant–negative inhibitor of p115, and sending a signal to the nucleus to induce other apoptotic processes.(A COOH-terminal fragment (right) but not)

依旧随遇而安

病毒转染干细胞

nauticus

谢谢分享  

MIYAGI

小生对楼主之仰慕如滔滔江水连绵不绝,海枯石烂,天崩地裂,永不变心.  

s06806

我该不会是最后一个顶的吧  

tuanzi

对不起，我走错地方了，呵呵  

tuanzi

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immail

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MIYAGI

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泡泡鱼

世界上那些最容易的事情中，拖延时间最不费力。