When LDH says "open," channels listen

杨柳

Jovanovic/Oxford3 O4 l! P; Z, a4 M8 g2 O) O$ y
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Achannel that protects cardiac cells from ischemia uses a rapid metabolite detection system to perceive dangerous conditions, according to new results from Russell Crawford, Aleksander Jovanovic, and colleagues (University of Dundee, Dundee, UK).
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A heart attack damages cells when anaerobic conditions disrupt active ion transport, leading to a toxic increase in intracellular Ca2 . A decrease in ATP levels initially impairs ion transport, causing depolarization and Ca2  import. However, low ATP may also trigger opening of ATP-sensitive K  (K ATP) channels, which would counteract the depolarization, ultimately reducing the time for Ca2  influx.
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But ATP regulation is not the whole story, as K ATP channels open before intracellular ATP levels drop enough to open the channel. This prompted the group to search for additional components. They have now found that lactate dehydrogenase (LDH) interacts directly with the channel subunits. LDH catalyzes the reversible conversion of pyruvate to lactate, and thus may supply a local concentration of lactate to the channel. Indeed, the group demonstrated that lactate opened the channel despite high levels of ATP. Further, this regulated opening was crucial for the channel's ability to protect from ischemia.
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Reference:
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Crawford, R.M., et al. 2002. EMBO J. 21:3936–3948.(Ca2  increase (white) in injured cells i)

xuguofeng

想都不想，就支持一下  

命运的宠儿

看看..  

nauticus

每天到干细胞之家看看成了必做的事情

龙水生

你加油吧  

beautylive

一个人最大的破产是绝望，最大的资产是希望。  

依旧随遇而安

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biobio

希望大家都有好运  

s06806

干细胞研究还要面向临床

s06806

青春就像卫生纸。看着挺多的，用着用着就不够了。