- 积分
- 61
- 威望
- 61
- 包包
- 304
|
RNA splicing: Layered regulation
8 i, k" g3 s# g8 J6 W! O
' S) _. L3 V5 p# SSarah Seton-Rogers1 k: E# f) p; r; D! m
# q1 Y& {0 q& N4 |8 {$ E. Y
AbstractAlternative splicing and epigenetic modifications, including the exchange of canonical histones for histone variants, are now widely accepted to contribute to the dysregulation of gene expression in cancer. Links between these layers of regulation are less clear, but a new study has uncovered a pathway in which alternative splicing of histone variant isoforms regulates the transcription of genes involved in tumour cell invasion.2 z3 H9 B$ j2 [. y1 i# a" i
9 l# u) M$ n1 S3 v5 p! _7 I
# f4 b; [1 y4 a5 h
! w4 t" I/ {4 N6 X- ^. q
http://www.nature.com/nrc/journal/v12/n11/full/nrc3388.html |
|