干细胞注射可能有助于治愈中风

坤明

最新的医学研究显示，及时注射干细胞对于中风患者的恢复至关重要。在老鼠身上所作的试验显示，在中风30分钟内注入干细胞几乎能使中风老鼠的大脑在两周内完全恢复正常。开展这一试验的玻利维亚拉帕斯医学院的科学家说，他们将从脂肪和骨髓中抽取的干细胞注入了刚刚被人为引发中风的老鼠的血管。相关研究发表于近期的《 Stem Cell Research and Therapy》上。' t7 Y) H0 K& _% J; G9 X7 X; \
1 P  }9 a! D0 v
结果表明，在这些干细胞尚未到达中风老鼠的脑部时，这些老鼠的康复状态已经好过那些未被注入干细胞的老鼠。
/ O" m- Y4 _  w! b  ]; k$ a0 ]
' _6 Y/ ^% x( A7 i" h在24小时内，这些被注入干细胞的老鼠的大脑显示了迅速的恢复。两周后，这些老鼠几乎完全恢复正常。拉帕斯医学院的科研人员说，这种方法对于治疗人类中风具有潜在的积极意义。但英国防治脑血栓协会的发言人沃尔顿医生说，将这种技术在人类身上进行试验可能不是近期的事情。
& [) ~9 {" E6 S# K% o7 k) g7 a, {: r0 O" l" W8 R5 [, g
对于许多中风患者来说，目前最为有效的治疗方法是在中风后最关键的头一个小时内注入“融栓剂”化解脑血管中的拴块。
# P& q+ ^5 L) u+ m

坤明

ffects of intravenous administration of allogenic bone marrow- and adipose tissue-derived mesenchymal stem cells on functional recovery and brain repair markers in experimental ischemic stroke) z; I3 N; C$ R5 }  l6 c% t  |
8 W0 ?4 f  H3 k
Stem Cell Research & Therapy, Published: 28 January 2013 |doi:10.1186/scrt1593 c$ x+ G# C9 P  h

$ S( |. y- C* {( u. e! a) sIntroduction
# m! h" n; R$ I: _5 T; l  S0 j: s7 |+ X, \! a
Stem cell therapy can promote good recovery from stroke. Several studies have demonstrated that mesenchymal stem cells (MSC) are safe and effective. However, more information regarding appropriate cell type is needed from animal model. This study was targeted at analyzing the effects in ischemic stroke of acute intravenous (i.v.) administration of allogenic bone marrow- (BM-MSC) and adipose-derived-stem cells (AD-MSC) on functional evaluation results and brain repair markers., x) G  C' p) O1 j% {1 t/ i5 S

8 O" P3 x2 i7 P& Y7 WMethods
& q: j; g5 e0 Y& s' g* K
. B7 a, B4 S4 e5 W6 v2 eAllogenic MSC (2x106 cells) were administered intravenously 30 minutes after permanent middle cerebral artery occlusion (pMCAO) to rats. Infarct volume and cell migration and implantation were analyzed by magnetic resonance imaging (MRI) and immunohistochemistry. Function was evaluated by the Rogers and rotarod tests, and cell proliferation and cell-death were also determined. Brain repair markers were analyzed by confocal microscopy and confirmed by western blot.# r$ R' ^# w$ X

& t( v& A) t: X/ D, @1 VResults
4 S# i6 m9 a4 n' ?7 ?+ I* F9 q( i3 j5 }. y! B0 L; I, o4 j# I
Compared to infarct group, function had significantly improved at 24 h and continued at 14 d after i.v. administration of either BM-MSC or AD-MSC. No reduction in infarct volume or any migration/ implantation of cells into the damaged brain were observed. Nevertheless, cell death was reduced and cellular proliferation significantly increased in both treatment groups with respect to the infarct group. At 14 d after MSC administration vascular endothelial growth factor (VEGF), synaptophysin (SYP), oligodendrocyte (Olig-2) and neurofilament (NF) levels were significantly increased while those of glial fiibrillary acid protein (GFAP) were decreased.7 x" U, [7 G  `+ F+ v

- q6 g1 V1 z0 B0 W" ~Conclusions
+ }0 \( V! e% m4 E  b" n0 @4 V2 g1 [4 x5 a4 u  @2 q
i.v. administration of allogenic MSC - whether BM-MSC or AD-MSC, in pMCAO infarct was associated with good functional recovery, and reductions in cell death as well as increases in cellular proliferation, neurogenesis, oligodendrogenesis, synaptogenesis and angiogenesis markers at 14 days post-infarct.
* f: K+ g- @# [. A3 }
) E/ J  c* Y* U) z2 V% n  aThe complete article is available as a provisional PDF. The fully formatted PDF and HTML versions are in production.

清水源

' g7 g' ?  Q" Z& q6 ~0 ?最新的医学研究显示，及时注射干细胞对于中风患者的恢复至关重要。在老鼠身上所作的试验显示，在中风30分钟内注入干细胞几乎能使中风老鼠的大脑在两周内完全恢复正常。
1 c  V6 k' @( R# ~! ~
) x2 d( z+ t- Z- q1 L7 b30分钟？ 要求有点难啊，脂肪和骨髓中的干细胞在30分钟中内可以制备好？ 可以直接注射？

lovesxj941

4 O, M' Y% Q' l

" ^2 N) ?# g7 h7 S- X4 u回复 清水源 的帖子
  n, I. v, J1 M6 P& G: q" S8 g8 L9 m; m8 x% b0 S
30分钟对于人来说就是可以放到4-8小时。