[Nature cell biology] February 2013, Volume 15 No 2全文

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0 _+ u  e5 k: m) o( hTurning Points
) y' Z4 v2 q1 @Virus entry: What has pH got to do with it? - p125
* N6 t. n% k* [Ari Helenius
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Full Text - Virus entry: What has pH got to do with it? | PDF (52 KB) - Virus entry: What has pH got to do with it?
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Tracing the cellular origin of cancer - pp126 - 134" U& ~/ o( Q6 ~9 D( b6 X' M
Cédric Blanpain
3 i( K3 |# ^1 V- B5 b  [2 V: |doi:10.1038/ncb2657' U: K2 N3 E' v4 o4 B3 n1 E. O
Cédric Blanpain discusses the progress achieved in identifying and characterizing the cellular origins of different solid tumours in mouse models of skin, brain, breast, gut and lung cancer, using genetic lineage tracing approaches.
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Abstract - Tracing the cellular origin of cancer | Full Text - Tracing the cellular origin of cancer | PDF (1,142 KB) - Tracing the cellular origin of cancer3 ]7 W& _( X, t% f
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News and Views7 ?* J* X+ |. k) P/ Y  i8 @9 y
Rab10 joins the ER social network - pp135 - 136
: q- E. v6 N- c: W# J) K' LJaerak Chang & Craig Blackstone& L# `' E  o$ @# e+ ], ^; {" Q% r
doi:10.1038/ncb2682
+ h) o7 o" F. f: E7 [) FThe endoplasmic reticulum (ER) is a heterogeneous organelle with distinct morphologies of sheets and an interconnected network of tubules sharing a common lumen. An ER domain marked by the Rab10 GTPase and several lipid-synthesizing enzymes is implicated in dynamic ER tubule formation and fusion events in cells." ]9 j( \+ K. H, I) O' b/ B
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Full Text - Rab10 joins the ER social network | PDF (152 KB) - Rab10 joins the ER social network. N5 e  p2 C  `( o% V& K
See also: Article by English & Voeltz. j- I, k/ Z5 @$ b9 j1 X4 Q+ p' C$ H6 {
Osmotic regulation of seamless tube growth - pp137 - 139% R! Q8 ?, a1 S: @
Jodi Schottenfeld-Roames & Amin S. Ghabrial
$ U0 S4 A! p6 R# _' x# gdoi:10.1038/ncb2683
7 Y( v% e5 I0 d1 l9 _4 x! CMost organs are composed of tubes of differing cellular architectures, including intracellular 'seamless' tubes. Two studies examining the morphogenesis of the seamless tubes formed by the excretory canal cell in Caenorhabditis elegans reveal a previously unappreciated role for osmoregulation of tubulogenesis: hyperosmotic shock recruits canalicular vesicles to the lumenal membrane to promote seamless tube growth." {, B  [; v" X* P
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Full Text - Osmotic regulation of seamless tube growth | PDF (262 KB) - Osmotic regulation of seamless tube growth: |* p% u3 X1 i3 T  ^( _& r* E
See also: Article by Khan et al. | Article by Kolotuev et al.5 B9 A7 x- @- a- {. h  ^0 {- L+ q& y
miR-29b moulds the tumour microenvironment to repress metastasis - pp139 - 140
2 t: U: r. q8 }9 MSonia A. Melo & Raghu Kalluri
. o2 c# _$ P; Cdoi:10.1038/ncb2684
1 r6 H& M) h4 V2 x. i! oTumour cells are influenced by their microenvironment, which can promote uncontrolled growth, invasion and metastasis. The GATA3 transcription factor is now shown to regulate the tumour microenvironment by inducing the expression of miR-29b in cancer cells. This microRNA in turn inhibits the expression of genes involved in angiogenesis and extracellular matrix signalling and remodelling to suppress metastasis.
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Full Text - miR-29b moulds the tumour microenvironment to repress metastasis | PDF (181 KB) - miR-29b moulds the tumour microenvironment to repress metastasis% m5 u) B1 W6 b
See also: Article by Chou et al.# V  H, ?0 @: a/ o" [$ \& c$ \" m
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Research Highlights
0 {+ G3 x: N( K5 \. {" Q% yFocal adhesions tug at matrix for rigidity sensingSorting Vangl2 at the GolgiScaling somitogenesisInterrogating Lkb1 function* n3 b5 b) |2 C; r
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Articles
% g! X1 G- g9 A6 S9 Y1 [Intracellular lumen extension requires ERM-1-dependent apical membrane expansion and AQP-8-mediated flux - pp143 - 156
: C, U$ j8 n9 V! @% F) N1 s! ZLiakot A. Khan, Hongjie Zhang, Nessy Abraham, Lei Sun, John T. Fleming, Matthew Buechner, David H. Hall & Verena Gobel0 ~3 \" H4 w4 b! h+ p4 I' V/ p
doi:10.1038/ncb26569 b+ A' C0 J8 e3 ?" J6 c
Gobel and colleagues show that the cortical protein ERM-1 drives expansion of the unicellular tube that constitutes the Caenorhabditis elegans excretory canal by recruiting membrane and cytoskeletal components, and the water channel aquaporin, to the apical side of the tube.
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7 Z5 U6 L) K& bAbstract - Intracellular lumen extension requires ERM-1-dependent apical membrane expansion and AQP-8-mediated flux | Full Text - Intracellular lumen extension requires ERM-1-dependent apical membrane expansion and AQP-8-mediated flux | PDF (2,440 KB) - Intracellular lumen extension requires ERM-1-dependent apical membrane expansion and AQP-8-mediated flux | Supplementary information: t5 E% o; g$ t% c3 L5 w$ K
See also: News and Views by Schottenfeld-Roames & Ghabrial$ Q: B6 D0 V) {% y3 o- G
A pathway for unicellular tube extension depending on the lymphatic vessel determinant Prox1 and on osmoregulation - pp157 - 168: [3 G+ _, f( m* N8 G4 W6 |
Irina Kolotuev, Vincent Hyenne, Yannick Schwab, David Rodriguez & Michel Labouesse
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+ r: }, F- Q' ~. C4 v" \- x7 Z, NLabouesse and colleagues examine the steps of excretory canal growth in nematodes. They delineate the importance of osmoregulated vesicle fusion with the lumen, and of a subapical cytoskeletal web to ensure straight lumen growth. They identify PROS-1 as a transcription factor essential for lumen growth through modulation of the osmosensitive kinase GCK-3 and intermediate filament protein IFB-1.& g5 A, U9 U6 W3 v8 a; g" H. z
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Abstract - A pathway for unicellular tube extension depending on the lymphatic vessel determinant Prox1 and on osmoregulation | Full Text - A pathway for unicellular tube extension depending on the lymphatic vessel determinant Prox1 and on osmoregulation | PDF (3,406 KB) - A pathway for unicellular tube extension depending on the lymphatic vessel determinant Prox1 and on osmoregulation | Supplementary information# ]7 Z7 Y' Q- H) D% S, [$ V
See also: News and Views by Schottenfeld-Roames & Ghabrial
: g5 Q% m/ A2 E+ ?) WRab10 GTPase regulates ER dynamics and morphology - pp169 - 178
$ A& R" G' ^8 q7 @; Q( Q3 q2 FAmber R. English & Gia K. Voeltz
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ER tubules grow and fuse to give the ER its characteristic shape. English and Voeltz show that the small GTPase Rab10 is crucial for ER tubule growth and fusion. Rab10 localizes to the leading edge of new ER tubules with enzymes that promote phospholipid synthesis, suggesting that ER tubule growth, fusion and phospholipid synthesis might be coupled.
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- U, m8 q% H  YAbstract - Rab10 GTPase regulates ER dynamics and morphology | Full Text - Rab10 GTPase regulates ER dynamics and morphology | PDF (3,114 KB) - Rab10 GTPase regulates ER dynamics and morphology | Supplementary information9 [4 D/ K( O- h  U+ F; ?! a* ?
See also: News and Views by Chang & Blackstone8 P9 N& t( ]+ p
SCFFbxw5 mediates transient degradation of actin remodeller Eps8 to allow proper mitotic progression - pp179 - 188
0 l  T7 o% c2 r3 Z5 Z9 _* nAchim Werner, Andrea Disanza, Nina Reifenberger, Gregor Habeck, Janina Becker, Matthew Calabrese, Henning Urlaub, Holger Lorenz, Brenda Schulman, Giorgio Scita & Frauke Melchior
: x7 _9 a' Y6 Xdoi:10.1038/ncb2661% |! e  _6 c; C& K/ z
Cortical actin is implicated in cell shape regulation during mitosis. Melchior and colleagues reveal that SCFFbxw5-mediated ubiquitylation and degradation of the actin remodeller Eps8 is required for timely cell rounding and progression into metaphase, whereas the capping activity of Eps8 is needed for mitotic exit.8 Q2 E4 e* P/ o+ o4 ^; {

6 S* }$ n1 |+ D+ A4 X8 t' K( pAbstract - SCFFbxw5 mediates transient degradation of actin remodeller Eps8 to allow proper mitotic progression | Full Text - SCFFbxw5 mediates transient degradation of actin remodeller Eps8 to allow proper mitotic progression | PDF (1,518 KB) - SCFFbxw5 mediates transient degradation of actin remodeller Eps8 to allow proper mitotic progression | Supplementary information! u4 r/ y( z$ W: O' D8 Q  b
Loss of Par3 promotes breast cancer metastasis by compromising cell–cell cohesion - pp189 - 200' H$ d0 w  ?* j. C
Bin Xue, Kannan Krishnamurthy, D. Craig Allred & Senthil K. Muthuswamy
' [  P# l+ c" s- [! A% Gdoi:10.1038/ncb2663
& Y. \5 a, O$ f0 n& d$ w& U' l. lMuthuswamy and colleagues demonstrated that loss of the Par3 polarity protein cooperates with ErbB2 activity to promote cell invasion and metastasis by destabilizing E-cadherin-dependent cell–cell junctions.
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Abstract - Loss of Par3 promotes breast cancer metastasis by compromising cell–cell cohesion | Full Text - Loss of Par3 promotes breast cancer metastasis by compromising cell–cell cohesion | PDF (2,835 KB) - Loss of Par3 promotes breast cancer metastasis by compromising cell–cell cohesion | Supplementary information
3 u4 I% N$ N) W- [# {5 xGATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expression - pp201 - 213
. K8 x) s9 H, P0 m, l. }* UJonathan Chou, Jeffrey H. Lin, Audrey Brenot, Jung-whan Kim, Sylvain Provot & Zena Werb3 C2 @  r. }: ~
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Werb and colleagues demonstrate that GATA3, a transcription factor that promotes luminal differentiation in the mammary gland, suppresses breast cancer metastasis to the lung by upregulating miR-29b. This microRNA suppresses pro-metastatic characteristics, including mesenchymal traits and the expression of microenvironmental factors involved in angiogenesis and extracellular matrix remodelling.' ~: h) R& @, \- o/ a
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Abstract - GATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expression | Full Text - GATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expression | PDF (2,753 KB) - GATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expression | Supplementary information, A" U6 R5 o+ X. X# }, C. D
See also: News and Views by Melo & Kalluri
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Letters6 Y) ?3 J% {# P$ n
Direct lineage reprogramming of post-mitotic callosal neurons into corticofugal neurons in vivo - pp214 - 221
. z3 y6 W4 Q! k" _Caroline Rouaux & Paola Arlotta2 g$ k- M, j  V) `: {8 x
doi:10.1038/ncb26602 i' V$ ~% N( G" k' _: W: o
Arlotta and Rouaux show that expression of the transcription factor Fezf2 in vivo is sufficient to redirect post-mitotic callosal projection neurons from one particular layer of the brain to corticofugal projection neurons that pertain to a different layer, including a redirection of their axonal connectivity.2 Y, L0 q% k0 G$ l3 e1 ]9 J( w. g; [

( R8 X' z+ ~" [! p9 @( p: C( |First Paragraph - Direct lineage reprogramming of post-mitotic callosal neurons into corticofugal neurons in vivo | Full Text - Direct lineage reprogramming of post-mitotic callosal neurons into corticofugal neurons in vivo | PDF (2,920 KB) - Direct lineage reprogramming of post-mitotic callosal neurons into corticofugal neurons in vivo | Supplementary information
; K% J9 b5 [- x3 j5 a! t5 ~! aAmputation-induced reactive oxygen species are required for successful Xenopus tadpole tail regeneration - pp222 - 228) l! {( z, r: \& r- {) O# ^2 d" p  ]1 }
Nick R. Love, Yaoyao Chen, Shoko Ishibashi, Paraskevi Kritsiligkou, Robert Lea, Yvette Koh, Jennifer L. Gallop, Karel Dorey & Enrique Amaya) }& \0 P# ?/ J# O2 X
doi:10.1038/ncb26599 J3 j3 f8 N0 {  S% H0 c+ A
Xenopus laevis and tropicalis tadpoles display incredible regenerative capacity of their tail. Amaya and colleagues find that tadpole tail amputation induces the production of reactive oxygen species (ROS) to induce cell proliferation and regeneration, through activation of the Wnt/β-catenin and Fgf20 signalling pathways.
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First Paragraph - Amputation-induced reactive oxygen species are required for successful Xenopus tadpole tail regeneration | Full Text - Amputation-induced reactive oxygen species are required for successful Xenopus tadpole tail regeneration | PDF (1,536 KB) - Amputation-induced reactive oxygen species are required for successful Xenopus tadpole tail regeneration | Supplementary information: j8 o0 o; `! c" E
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Erratum' \5 M+ G: }9 l! J1 F" D
Phosphorylation-enabled binding of SGO1–PP2A to cohesin protects sororin and centromeric cohesion during mitosis - p2291 U4 C, G5 m7 Q5 X$ E
Hong Liu, Susannah Rankin & Hongtao Yu' ^2 V3 W, Y" r; R) O6 Y# w
doi:10.1038/ncb2688: h1 ^2 k( Q3 }6 h
Full Text - Phosphorylation-enabled binding of SGO1–PP2A to cohesin protects sororin and centromeric cohesion during mitosis | PDF (245 KB) - Phosphorylation-enabled binding of SGO1–PP2A to cohesin protects sororin and centromeric cohesion during mitosis
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, ]$ b1 o. o6 K$ R2 q- oCorrigendum
* e( w* c3 Q+ |Humans put their eggs in more than one basket - p229
# k0 Y% m3 Z7 x+ g! o6 c, t- \Diana J. Laird
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Full Text - Humans put their eggs in more than one basket | PDF (245 KB)

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