求Nature Genetics文献一篇，谢谢

f5_105

' x9 ]% f! U# k- W. B& J, R
, x* d5 E: U( J
Nat Genet. 2013 Mar;45(3):239-41. doi: 10.1038/ng.2530. Epub 2013 Jan 20.
! m4 ^6 l' f+ k$ n: u) L/ \XACT, a long noncoding transcript coating the active X chromosome in human pluripotent cells.
4 L( t! t* f* P- w* IVallot C, Huret C, Lesecque Y, Resch A, Oudrhiri N, Bennaceur-Griscelli A, Duret L, Rougeulle C.. ~/ E  T& P5 x) ~, Y! M" |& D7 n
Source
5 ]2 C; W: W! ?2 m: z9 g- n1] Université Paris Diderot, Sorbonne Paris Cité, Epigenetics and Cell Fate, Paris, France. [2] Centre National de la Recherche Scientifique (CNRS), Unité Mixte de Recherche (UMR) 7216 Epigenetics and Cell Fate, Paris, France.3 }0 a, H- Z( d3 Y7 x
Abstract9 z) y! x1 g0 ~! [& y- T
X-chromosome inactivation (XCI) in mammals relies on XIST, a long noncoding transcript that coats and silences the X chromosome in cis. Here we report the discovery of a long noncoding RNA, XACT, that is expressed from and coats the active X chromosome specifically in human pluripotent cells. In the absence of XIST, XACT is expressed from both X chromosomes in humans but not in mice, suggesting a unique role for XACT in the control of human XCI initiation.
7 p5 ]) l9 i. r2 N$ d; z3 Vhttp://www.nature.com/ng/journal/v45/n3/full/ng.2530.html
( [1 ]  Y" \. b6 C8 v. d7 A2 q7 c$ G

yusheen