Diabetes：一种治疗糖尿病患者创伤的干细胞疗法

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Diabetes：一种治疗糖尿病患者创伤的干细胞疗法
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高威国立大学的研究者通过临床前期研究揭示了，使用成体干细胞来作为糖尿病患者伤口的一种疗法。6 f& b$ a! z' k0 r8 q; G
2013年3月14日，一项刊登在国际杂志Diabetes上的研究论文中，来自高威国立大学的研究者通过临床前期研究揭示了，他们可以使用成体干细胞来作为糖尿病患者伤口的一种疗法。
, I4 i9 U0 a& o7 E$ `# W# d6 u研究中，研究者使用了一种名为间质干细胞（MSC）的干细胞，与一种胶原生物材料结合使用，从而可以增加糖尿病患者伤口愈合的速度。糖尿病患者自身伤口愈合的能力出现了缺陷，对于那些患有足溃疡的病人来说开发有效的疗法来改善其伤口愈合非常关键。足溃疡会影响25%的糖尿病患者一生的健康，最后甚至有可能会导致患者进行截肢手术。2 j1 F2 }/ o; y' }9 e4 I, A! J
过去一些年里，研究者通过研究开发出了一些新型的方法来增加糖尿病患者伤口的愈合速度。研究者O’Brien说，这些研究数据将帮助我们加速在人类机体中进行研究，目前我们已经准备开始着手进行人体试验。2 {4 \2 B8 D! q  Z0 x( r; V% {
MSC具有很多诱人的治疗潜力，其可以从成年人机体中分离出来，并且容易在实验室条件下生长，其可以释放特殊的因子来帮助心血管的形成和生长，当然，增加血流是伤口愈合的关键。最后研究者表示，他们希望他们的研究数据可以帮助开发新型的治疗糖尿病患者创伤的疗法，这或许对于众多的糖尿病患者来说是一大福音。（生物谷Bioon.com）9 ~2 \3 Y1 |. y# q

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doi:10.2337/db12-18224 c6 |, R7 i0 ?4 m5 D3 N5 @& {9 j, K8 D
PMC:
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+ \. z5 b. O* s+ MTopical Administration of Allogeneic Mesenchymal Stem Cells Seeded in a Collagen Scaffold Augments Wound Healing and Increases Angiogenesis in the Diabetic Rabbit Ulcer 2 N9 |$ R5 Q( P( m; h
Aonghus O’Loughlin1, Mangesh Kulkarni2, Michael Creane1, Erin Vaughan1, Emma Mooney1, Georgina Shaw1, Mary Murphy1, Peter Dockery3, Abhay Pandit2 and Timothy O’Brien1
4 I+ d3 p7 I" |There is a critical clinical need to develop therapies for non-healing diabetic foot ulcers. Topically applied mesenchymal stromal cells (MSCs) provide a novel treatment to augment diabetic wound healing. A central pathological factor in non-healing diabetic ulcers is an impaired blood supply. It was hypothesized that topically applied allogeneic MSCs would improve wound healing by augmenting angiogenesis. Allogeneic non-diabetic bone-marrow derived MSCs were seeded in a collagen scaffold. The cells were applied to a full thickness cutaneous wound in the alloxan-induced diabetic rabbit ear ulcer model in a dose escalation fashion. Percentage wound closure and angiogenesis at 1 week was assessed using wound tracings and stereology respectively. The topical application of 1,000,000 MSCs on a collagen scaffold demonstrated increased percentage wound closure when compared to lower doses. The collagen and collagen seeded with MSCs treatments result in increased angiogenesis when compared to untreated wounds. An improvement in wound healing as assessed by percentage wound closure was observed only at the highest cell dose. This cell-based therapy provides a novel therapeutic strategy for increasing wound closure and augmenting angiogenesis which is a central patho-physiological deficit in the non-healing diabetic foot ulcer. 7 `8 d  F4 r. f! @4 r! e

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chb611301

thanks for sharing

chb611301

好文章
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