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本帖最后由 naturalkillerce 于 2013-3-21 18:11 编辑
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干细胞注射可缓解骨关节炎疼痛/ l# O0 ]4 U# O7 h
naturalkillerce:埃默里骨科与脊柱中心提供一种前沿的干细胞疗法来治疗骨关节炎。这种方法涉及从病人臀部的骨髓中提取出含干细胞血液,移除血浆,利用离心机浓缩剩余的液体,随后将这种混合物直接注射到受损关节中。由于这些物质来自病人自身,所以产生免疫排斥的几率很小。尽管一些病人接受这种干细胞疗法之后表现得比其他病人更好,但是这种疗法的副作用是暂时性的和局部的。注射带来的微痛只持续几天时间,大多数病人在很短的时间内恢复到正常的活动。
% @& K) X- s6 b6 A- u在此之前,常规性的用于治疗与骨关节炎相关的疼痛的方法包括物理疗法、职业疗法、皮质类固醇(cortical steroid)疗法和透明质酸疗法。注射皮质类固醇能够短期缓解疼痛,但是疼痛经常会复发,并且在一段时间后,情况会变得更加糟糕。此外,透明质酸能够润滑关节,有时可缓解疼痛,但是它不能恢复丢失的组织。但是,干细胞能够分化为多种不同类型的供人体使用的细胞,如新的软骨细胞,因而引起人们的极大关注。
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原始新闻参考:
1 X6 V0 ^* O9 uStem cell injections to relieve arthritis pain 6 ]# C8 u# \1 o8 S# g. M# o2 B' H
March 20, 2013 in Arthritis & Rheumatism 5 Z5 W+ n6 V5 x4 l4 C
(Medical Xpress)—Emory Orthopaedics & Spine Center is now one of a small number of clinics in the country to offer a cutting edge stem cell treatment for Osteoarthritis (OA)./ Y# n& a/ L( [& X. l* S3 R6 ^( I+ u& c
The procedure involves extracting stem cell blood from the bone marrow in a patient's hip, removing the plasma, concentrating the remaining fluid in a centrifuge, and then injecting the concoction directly into the damaged joint. Because the material is a patient's own, there is little chance the body will reject it. ! c9 z2 B2 W" y. b8 E$ c% P K( u
Kenneth Mautner, MD, an expert in physical and rehabilitative medicine at Emory's Sports Medicine Center, prescribes many conventional treatments for the pain associated with OA, such as physical and occupational therapy, cortical steroids and hyaluronic acid, but is most excited by the promise that stem cell therapy offers.
3 D# D5 T2 y# u! u"There are only so many non-surgical options that are available," says Mautner. "In the past we've done cortical steroid injections, which can give short-term relief for pain, but oftentimes the pain comes back, and it actually can worsen the problem over time."
i1 b6 r: Q+ V* n5 XMautner, who also is an assistant professor in the Department of Orthopaedics at Emory University School of Medicine, points out that while hyaluronic acid can help lubricate the joint and sometimes relieve pain, it does nothing to restore lost tissue. Stem cells, on the other hand, are cells that have the ability to develop into many different kinds of cells the body uses, such as new cartilage.
( X2 w; k# \) C0 V% Z Y, ]"We hope that by placing an abundance of those cells directly in the area that's deficient, healthier cells will grow."
) B( b+ C7 ?8 eOsteoarthritis is one of the oldest and most common forms of arthritis, and is characterized by an erosion of the protective cartilage in joints. As cartilage wears down, bones can rub against one another causing pain, stiffness and a loss of mobility. Load-bearing joints such as the knees and hips are often the first to feel the ravages of the disease. While the exact cause of OA is not known, factors such as age, obesity, injury and genetics all play a role in its progression.
4 X5 h/ Y& h0 w( c8 k8 EThough some patients fare better than others with the treatment, side effects tend to be temporary and localized. Minor pain from the injection only lasts a few days, and most people are back to their normal activities within a short period of time. : Q$ g8 Y. j, p/ D, N6 p2 M4 B
Meanwhile, Mautner and others are learning more about which patients will ultimately make the best candidates for this type of therapy. For many who are facing joint-replacement surgery, having a stem cell injection is a small gamble when the outcome may postpone or avert a major surgery. Presently, that gamble is likely to come solely from the patient's own pocketbook since the experimental treatment is not currently covered by most medical insurance.
% O6 g. f" o6 l7 P) H. p7 Rhttp://medicalxpress.com/news/20 ... arthritis-pain.html |
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