PDF电子书：Embryonic Stem Cells – Differentiation and Pluripotent Alternatives

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Embryonic Stem Cells – Differentiation and Pluripotent Alternatives
" B1 {$ w! g! `7 `4 N" ?, eEdited by Michael S. Kallos
* V7 H: d9 W: q( F( H) hPublished by InTech" O: N0 k* `  X. ^% {, \
Janeza Trdine 9, 51000 Rijeka, Croatia# {' ~; e0 J: k9 w
Copyright © 2011 InTech2 K2 o3 M/ ?1 {- c+ |

6 E6 I- J8 x; rContents* _0 _, a& x* L) l0 G
Preface IX+ D2 U6 |5 r  ?. k
Part 1 General Differentiation 1
( O- ^  C' [+ L6 m. ~. cChapter 1 Role of Signaling Pathways and Epigenetic5 l% I% ~* P# w+ a( o; b, W& p* u
Factors in Lineage Determination During, |: t6 [* P6 S- X- x- J$ a$ l
Human Embryonic Stem Cell Differentiation 3
, L. a0 {: K% S% {% \Prasenjit Sarkar and Balaji M. Rao+ m; U& i) i5 }8 V9 k! E9 J
Chapter 2 Bioactive Lipids in Stem Cell Differentiation 33
* ^) l+ t. X- c8 tErhard Bieberich and Guanghu Wang# _; l7 r8 f' Q5 X; `; i. Q
Chapter 3 Retinoid Signaling is a Context-Dependent
; x6 r; ?" H2 O" N* t  p' SRegulator of Embryonic Stem Cells 557 o" y% q3 f5 v  R
Zoltan Simandi and Laszlo Nagy# c0 l7 P' A7 s/ h
Part 2 Neural and Retinal Differentiation 794 e8 e) L, S# Y0 H9 L, t) q9 @7 l
Chapter 4 Pluripotent Stem Cells as an In Vitro
# G+ ]- E5 u# M' r2 q" |! [  K, uModel of Neuronal Differentiation 81
3 T+ r) e1 p7 d+ hIrina Kerkis, Mirian A. F. Hayashi," m% c, j" N: s! k1 F
Nelson F. Lizier, Antonio C. Cassola," V8 {7 ?1 w! e1 v3 {$ q
Lygia V. Pereira and Alexandre Kerkis5 l6 c& H/ m! [4 Q% M7 `
Chapter 5 Characterization of Embryonic Stem (ES)+ x$ w' _# g% U6 ]
Neuronal Differentiation Combining Atomic Force,$ t/ T1 M" i$ @, A  p
Confocal and DIC Microscopy Imaging 99
2 `( e6 A) p/ K+ e8 }Maria Elisabetta Ruaro, Jelena Ban and Vincent Torre
( X5 Q1 {+ Y1 \* mChapter 6 Oligodendrocyte Fate Determination
( Q1 a3 \  ?( x6 f' X: bin Human Embryonic Stem Cells 119
/ U+ q$ ?; F& |+ sSiddharth Gupta, Angelo All and Candace Kerr5 ?- e- u' k! r7 B
Chapter 7 Stem-Cell Therapy for Retinal Diseases 135# U/ y- @4 v. ~3 @5 B' o" Q
Rubens Camargo Siqueira0 O& |; V1 q# T$ {% F) l
VI Contents6 T9 p3 m4 }0 m
Part 3 Cardiac and Other Myogenic Differentiation 1498 c( {1 }+ n7 n6 a' P5 V
Chapter 8 Transcriptional Networks6 J- o2 S$ A# v- d& J- J
of Embryonic Stem Cell-Derived Cardiomyogenesis 1519 }8 b/ Y7 c: F3 T1 D4 U; O& E
Diego Franco, Estefania Lozano-Velasco and Amelia Aránega
, @/ k) }4 M$ L3 F8 B0 hChapter 9 Human Pluripotent Stem Cells* B4 G" Z' z9 \% Y0 O3 h
in Cardiovascular Research and Regenerative Medicine 169
; w0 p/ ^5 Z( y# Y; aEllen Poon, Chi-wing Kong and Ronald A. Li
. @3 ~; I6 t; S" {  RChapter 10 Human Pluripotent Stem Cell-Derived Cardiomyocytes:( o# W3 r& q; ?5 m  c+ G9 }
Maturity and Electrophysiology 185
1 S7 a: G  v! h& R  c( P, \Ville Kujala, Mari Pekkanen-Mattila and Katriina Aalto-Setälä
1 [  X% J/ k- P, N5 m3 q/ ?Chapter 11 Maintenance Of Calcium Homeostasis$ i/ e: y: Y% A1 h
in Embryonic Stem Cell-Derived Cardiomyocytes 205+ r9 I/ m2 n  ?3 U) @) w9 o
Iek Chi Lo, Chun Kit Wong and Suk Ying Tsang& |9 c  b0 P1 d; h  \* Q! G! t
Chapter 12 Myogenic Differentiation of ES Cells for Therapies! v0 L* V& K2 X, g4 a
in Neuromuscular Diseases: Progress to Date 227
5 T; [& _7 m* I2 M6 T# }! CCamila F. Almeida, Danielle Ayub-Guerrieri and Mariz Vainzof
) b' [0 y3 B9 a4 U# KPart 4 Endothelial Differentiation 243
5 P' x0 Z) a' y- ZChapter 13 Dissecting the Signal Transduction Pathway0 L* l- K9 t! i$ w; |
that Directs Endothelial Differentiation Using
4 P1 Y; o# A. h; j; \$ P& o. G7 kEmbryonic Stem CellDerived Vascular Progenitor Cells 245. Q/ J& b7 L- }6 B+ e% r
Kyoko Kawasaki and Keiji Miyazawa6 I) ^  m. }1 t* d- k9 M
Chapter 14 Endothelial Differentiation of Embryonic Stem Cells 267
1 b6 H7 W: U9 G1 G, t0 T( _Peter Oettgen
5 t3 y4 M& L/ K' O3 N# ]: H, v3 ^Part 5 Hepatic Differentiation 277* G3 f. m- Y7 E) x1 b" m* {
Chapter 15 Stem Cells for HUMAN Hepatic Tissue Engineering 279
1 {' `6 |+ f+ e, p) q& D' UN.I. Nativ, M.A. Ghodbane, T.J. Maguire,3 k' O) {1 q1 \/ W7 _
F. Berthiaume and M.L. Yarmush) {. V( [$ m3 k! f$ g% [8 g
Chapter 16 Hepatic Differentiation of Human Embryonic and Induced
3 Z/ L3 m9 W+ d) h, \# X: iPluripotent Stem Cells for Regenerative Medicine 303
! G5 K/ ~: o9 P8 R+ V. s' I9 ?" OToshio Miki& @! x: \" c  [& P* U8 s
Part 6 Osteogenic Differentiation 321: @) M. n% r7 V6 Y* F7 {% T
Chapter 17 Osteogenesis from Pluripotent Stem Cells:% s6 d# b1 \8 Y6 j& `% A
Neural Crest or Mesodermal Origin? 3230 p$ Z' B; _2 J: ?
Kevin C. Keller and Nicole I. zur Nieden8 J: z- [& r& G% G5 @
Contents VII
. G: }5 \. I) {! h" y: FPart 7 Pluripotent Alternatives –1 A8 x" H: k4 D& h8 {9 z, x
Induced Pluripotent Stem Cells (iPSCs) 3494 U2 `0 Q* g: [: S6 c8 Y3 N
Chapter 18 The Past, Present and Future of
6 m! n2 l9 A3 iInduced Pluripotent Stem Cells 351
/ I# c( j+ x, r& f4 tKoji Tanabe and Kazutoshi Takahashi
3 V/ q% i& l: r( y& b4 oChapter 19 New Techniques in the Generation/ E8 _4 w* z* O( F" S, A
of Induced Pluripotent Stem Cells 3736 z1 M  ]  i8 [
Raymond C.B. Wong, Ellen L. Smith and Peter J. Donovan
. g6 N6 ~! ~4 W9 R8 bChapter 20 Generation of ICM-Type Human iPS Cells
) L* {* d. N; p! F, gfrom CD34+ Cord Blood Cells 399
! R7 p0 j; P# u1 E$ K' R& I+ qNaoki Nishishita, Noemi Fusaki and Shin Kawamata
! S0 Z" T9 ^/ m+ t8 H0 AChapter 21 Modelling of Neurological Diseases
5 e( C( U6 W" p9 Y6 I0 W, @Using Induced Pluripotent Stem Cells 4130 G0 e: t4 N' M9 x  U3 O
Oz Pomp, Chen Sok Lam, Hui Theng Gan,6 n3 X2 M( b8 f8 m$ \, Y% j
Srinivas Ramasamy and Sohail Ahmed$ Y4 a8 J* ]& u% r$ T6 r
Part 8 Pluripotent Alternatives - Other Cell Sources 431
/ g% x  N8 [8 E$ J4 n0 }Chapter 22 Very Small Embryonic/Epiblast-Like Stem Cells (VSELs)
: i# K) o# K5 ]7 x/ NResiding in Adult Tissues and Their Role
: k. k2 R* I' bin Tissue Rejuvenation and Regeneration 433
/ D/ `9 E8 l# w3 G! ZDong-Myung Shin, Janina Ratajczak,. Z; w2 d7 b* k( J  j! f
Magda Kucia and Mariusz Z. Ratajczak8 {) C- G" Z+ j
Chapter 23 Multipotent Dental Stem Cells:' n8 |+ ^5 H2 y/ `& j: A" T
An Alternative Adult Derived Stem: k, a9 u8 [. [* M' \! S! C
Cell Source for Regenerative Medicine 451
2 V$ Z) [/ k; ]2 }  X* Z  qTammy Laberge and Herman S. Cheung
# [9 p) Y; G- pChapter 24 Pluripotent Stem Cells from Testis 473
5 ~, {4 a- X* H1 V" W. Y5 gSandeep Goel and Hiroshi Imai
, d: q' D: F% m% Z( [( x- ]! ]Chapter 25 Amniotic Fluid Stem Cells 493. t# ^3 }- |& p6 \% i
Gianni Carraro, Orquidea H. Garcia,
9 O, c9 c& p) O8 q% WLaura Perin, Roger De Filippo and David Warburton
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