PDF电子书：Embryonic Stem Cells – Differentiation and Pluripotent Alternatives

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0 j" l; h4 _# f, dEmbryonic Stem Cells – Differentiation and Pluripotent Alternatives
: P- P  `/ F" V% k, TEdited by Michael S. Kallos9 R6 l6 f6 a7 d8 i$ h, Y
Published by InTech0 {* l$ r8 t% j1 ?
Janeza Trdine 9, 51000 Rijeka, Croatia. z1 R8 r6 n/ B6 y9 l! |2 A) K
Copyright © 2011 InTech
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Contents
4 ^9 \4 w! I8 _$ @Preface IX
/ [2 c" Q$ D, G0 K8 UPart 1 General Differentiation 1* p0 J0 v! K9 n/ ^6 h
Chapter 1 Role of Signaling Pathways and Epigenetic$ y; S$ f0 N$ X8 _" M& b
Factors in Lineage Determination During
! ^( [* i) E. _1 G$ G. C' {7 i1 {, uHuman Embryonic Stem Cell Differentiation 31 b0 M* ?" s0 j9 _: B
Prasenjit Sarkar and Balaji M. Rao6 X8 O+ R5 [3 o7 \- q. F  Y# u
Chapter 2 Bioactive Lipids in Stem Cell Differentiation 33
( d4 w/ J" Y0 A; AErhard Bieberich and Guanghu Wang0 `/ g' w- L' O7 `5 H
Chapter 3 Retinoid Signaling is a Context-Dependent, |, _6 [1 G2 e5 b9 b
Regulator of Embryonic Stem Cells 55
% W! ^+ y2 v4 l/ y: W0 e& _5 LZoltan Simandi and Laszlo Nagy
1 N+ }+ U6 I1 s& {Part 2 Neural and Retinal Differentiation 79
# Q3 @3 l& k, y: G& @Chapter 4 Pluripotent Stem Cells as an In Vitro
7 W2 ?5 P: L' a% h7 O* i* x4 X% T. F& mModel of Neuronal Differentiation 81
& R, K3 d3 F  ^" NIrina Kerkis, Mirian A. F. Hayashi,7 c1 I& d& i+ E8 @
Nelson F. Lizier, Antonio C. Cassola,
+ |  C  N/ _6 g7 M( a" ULygia V. Pereira and Alexandre Kerkis
& {+ t! `: b8 K$ N8 N" ^Chapter 5 Characterization of Embryonic Stem (ES)
% w' ?" @* q) a$ YNeuronal Differentiation Combining Atomic Force,
" M! c7 t' _( _( EConfocal and DIC Microscopy Imaging 99
% G* |: H( w: j* {Maria Elisabetta Ruaro, Jelena Ban and Vincent Torre( Y$ N! s3 G, {' `6 O9 l* r
Chapter 6 Oligodendrocyte Fate Determination1 J) n) X0 }3 `% }8 R
in Human Embryonic Stem Cells 119# \2 }* g- `" |0 \# ]
Siddharth Gupta, Angelo All and Candace Kerr& F3 z- m' ~$ o, ]2 f* Y: L+ Q
Chapter 7 Stem-Cell Therapy for Retinal Diseases 135
4 O; K6 {: W/ \% rRubens Camargo Siqueira& m- o: ]" e& G5 ?5 ^; I1 n
VI Contents& b; u* _# I9 R
Part 3 Cardiac and Other Myogenic Differentiation 149
) g1 C4 k* D5 U& ?$ I# VChapter 8 Transcriptional Networks
& d0 r  j" t, Uof Embryonic Stem Cell-Derived Cardiomyogenesis 151
/ z+ Z2 L4 d9 sDiego Franco, Estefania Lozano-Velasco and Amelia Aránega' D' x5 {! X0 a( E- R! G
Chapter 9 Human Pluripotent Stem Cells3 e4 W8 E- C% F, c7 _9 f, b
in Cardiovascular Research and Regenerative Medicine 1698 m. l* K2 E# X( L  n7 Z& i0 n9 ?
Ellen Poon, Chi-wing Kong and Ronald A. Li0 k. l% G: y5 `3 }
Chapter 10 Human Pluripotent Stem Cell-Derived Cardiomyocytes:' _5 S3 Z* Q9 ?! R& R$ Q% H! @
Maturity and Electrophysiology 185; m/ ~- c; I) k6 f0 R! s' c* t
Ville Kujala, Mari Pekkanen-Mattila and Katriina Aalto-Setälä) x/ m4 d( m2 ]! j+ z6 }$ U
Chapter 11 Maintenance Of Calcium Homeostasis
, ~0 T) x. c0 N  Vin Embryonic Stem Cell-Derived Cardiomyocytes 205
0 P# q' |) a( o6 M; d4 S. [2 k4 N6 C* ?Iek Chi Lo, Chun Kit Wong and Suk Ying Tsang( H- l0 G5 u/ h/ n2 k, a
Chapter 12 Myogenic Differentiation of ES Cells for Therapies
( x% {* ^+ Z  Y, k  h8 t/ T# uin Neuromuscular Diseases: Progress to Date 227
0 \5 ?. q, }" o9 l3 R" LCamila F. Almeida, Danielle Ayub-Guerrieri and Mariz Vainzof
  \/ }* L2 s& P$ ]Part 4 Endothelial Differentiation 243
% C% _1 L/ x8 h" ~8 ?3 V' cChapter 13 Dissecting the Signal Transduction Pathway) I/ y( u1 h/ n, L& m/ c
that Directs Endothelial Differentiation Using% w9 G! \1 o# w9 S
Embryonic Stem CellDerived Vascular Progenitor Cells 245( }) ^) E7 f3 m3 y' Q7 I/ g
Kyoko Kawasaki and Keiji Miyazawa
* ?5 l# q8 c4 l+ UChapter 14 Endothelial Differentiation of Embryonic Stem Cells 2676 [/ h/ j/ E# `% [0 `6 x5 ~2 B
Peter Oettgen+ J) i2 M+ o9 _6 r
Part 5 Hepatic Differentiation 2775 y3 k9 j8 P' f7 u
Chapter 15 Stem Cells for HUMAN Hepatic Tissue Engineering 279, x7 b6 i# ^) {9 S9 L; s
N.I. Nativ, M.A. Ghodbane, T.J. Maguire,
9 a# N: C% {$ H( b2 P. pF. Berthiaume and M.L. Yarmush
) w, e) @, _+ ?/ tChapter 16 Hepatic Differentiation of Human Embryonic and Induced
4 v+ ~/ J0 J+ ?" @1 tPluripotent Stem Cells for Regenerative Medicine 303
8 J) v" t# j/ T, _Toshio Miki7 C' u  ^0 g) D; _0 W* p- J3 k3 \
Part 6 Osteogenic Differentiation 321, @& j' E; w% o' d
Chapter 17 Osteogenesis from Pluripotent Stem Cells:3 z+ }0 _6 i& X
Neural Crest or Mesodermal Origin? 3237 P3 ~: ~0 j: D: t- z3 U9 A
Kevin C. Keller and Nicole I. zur Nieden1 M# B5 Y4 p* e1 o/ X$ V, g
Contents VII
0 Q- K. ]- ]! U8 a- ~Part 7 Pluripotent Alternatives –; O2 t1 ]0 {, U9 ]$ ~4 D
Induced Pluripotent Stem Cells (iPSCs) 349
! h; U1 f, L) |/ R4 z7 i9 kChapter 18 The Past, Present and Future of
  B! |: {& v! ]Induced Pluripotent Stem Cells 351
7 d0 g  {$ y( [: _Koji Tanabe and Kazutoshi Takahashi7 `  T: F7 e( }; L: Q' n
Chapter 19 New Techniques in the Generation4 t/ c8 X9 I; \5 @2 C/ p
of Induced Pluripotent Stem Cells 373
9 q. a5 x2 J1 g/ t+ bRaymond C.B. Wong, Ellen L. Smith and Peter J. Donovan7 o. [# J* N% y5 j5 N, S( R5 W
Chapter 20 Generation of ICM-Type Human iPS Cells
0 O. R* Z! Q5 V* h. f- gfrom CD34+ Cord Blood Cells 3993 k- b" V7 q6 @* n8 Z2 ?8 R
Naoki Nishishita, Noemi Fusaki and Shin Kawamata5 f: C4 x9 f& h! q( e
Chapter 21 Modelling of Neurological Diseases
! R  v! i" t( R1 WUsing Induced Pluripotent Stem Cells 4136 c3 x# k) N! F! V3 q
Oz Pomp, Chen Sok Lam, Hui Theng Gan,- o& m' `$ X" ~0 S( u, h
Srinivas Ramasamy and Sohail Ahmed
8 N' d% g8 S' f6 i' l* M' @5 ]; ~Part 8 Pluripotent Alternatives - Other Cell Sources 4319 x! y* r" H- D9 B
Chapter 22 Very Small Embryonic/Epiblast-Like Stem Cells (VSELs)
+ U: V. I. C( v& e, z; sResiding in Adult Tissues and Their Role1 p) n( I9 E# F; V8 N; O1 T. F9 `- a
in Tissue Rejuvenation and Regeneration 433
0 s) T1 B" t) g) b+ b2 nDong-Myung Shin, Janina Ratajczak,9 l& w: f4 @# F4 B# T7 w  k
Magda Kucia and Mariusz Z. Ratajczak
& k' i! a3 q- |3 [' yChapter 23 Multipotent Dental Stem Cells:
) d5 g0 {. _  P1 l# c: x7 VAn Alternative Adult Derived Stem
: ^( \1 K+ k% OCell Source for Regenerative Medicine 451# d7 Y& d8 n& y+ L: Y1 r
Tammy Laberge and Herman S. Cheung
3 [% X3 s- ~! c$ j& ^! eChapter 24 Pluripotent Stem Cells from Testis 473
; h1 X* m2 ^3 t  I! m* h+ _8 v! NSandeep Goel and Hiroshi Imai
' _/ s9 e8 o  Z7 Q+ m7 }Chapter 25 Amniotic Fluid Stem Cells 493. L) @% Y: X% @+ N# _# Q+ B' u
Gianni Carraro, Orquidea H. Garcia,
2 o  ~0 F- l: i6 m! {Laura Perin, Roger De Filippo and David Warburton% b/ i: n/ ]3 V6 a' E. b

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