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Centrosomes lead stem cell orientation [复制链接]

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楼主
发表于 2009-3-6 00:57 |只看该作者 |倒序浏览 |打印
Fuller/AAAS* l0 y8 g- c$ X( W) H7 z

# y9 `% ], H7 ~. Y. S. yStem cells in the fly male germ line can both maintain their numbers and produce differentiating progeny by correctly orienting cell division, according to Yukiko Yamashita, D. Leanne Jones, and Margaret Fuller (Stanford University, Stanford, CA).
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Asymmetric cell division is associated with control over spindle orientation in several models, such as the fly neuroblast and the worm P1 cell. In both of these cases, the spindle is reoriented during mitosis. But in fly germline stem cells (GSCs), which divide asymmetrically to produce one stem cell and one cell that initiates differentiation, Fuller's group now shows that the GSCs are oriented throughout the cell cycle, not just during mitosis.GSCs align themselves with the surface of their niche, known as the hub〞a cluster of somatic cells in the testes that instruct neighboring GSCs to retain stem cell identity. Yamashita et al. show that GSCs build their spindle perpendicular to the hub by keeping one centrosome in close contact with the hub〞even during interphase. After the cell divides, one daughter remains connected to the hub, and thus maintains stem cell identity, whereas the other daughter is displaced away and differentiates. Disruption of centrosome function interferes with this polarity. As a result, both daughter cells contact the hub, leading to an excess of GSCs.& m8 M+ s' i2 Y. K1 R) _) n% o
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The boundary between the hub and the GSC contained high levels of cadherins and a fly homologue of APC, which is thought to help orient spindles in epithelial cells. APC mutant GSCs have mispositioned centrosomes, misoriented spindles, and an excess of GSCs. Thus, the APC–cadherin complex may anchor one GSC centrosome near the hub, leaving the other free to roam.* w8 b+ g$ O1 x1 z' ^/ ]
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, N8 r( z9 r# u1 l6 ^+ |8 TYamashita, Y.M., et al. 2003. Science. 301:1547–1550.(A spindle perpendicular to the hub ensur)

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沙发
发表于 2015-6-17 11:10 |只看该作者
我起来了 哈哈 刚才迷了会  

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藤椅
发表于 2015-7-21 15:18 |只看该作者
支持你一下下。。  

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板凳
发表于 2015-8-1 10:18 |只看该作者
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楼主,支持!  

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报纸
发表于 2015-8-11 17:35 |只看该作者
谢谢干细胞之家提供资料

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地板
发表于 2015-8-23 07:07 |只看该作者
你还想说什么啊....  

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发表于 2015-10-2 21:46 |只看该作者
非常感谢楼主,楼主万岁万岁万万岁!  

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发表于 2015-10-31 16:43 |只看该作者
真是汗啊  我的家财好少啊  加油  

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发表于 2015-12-24 20:35 |只看该作者
挺好啊  

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发表于 2016-1-14 11:35 |只看该作者
干细胞研究还要面向临床
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