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The end products of this decision are the bacteria-fighting Th1 cells and the parasite-fighting Th2 cells. Activation of the interferon- receptor (IFNGR) or interleukin 4 receptor (IL-4R) is known to favor Th1 production or Th2 production, respectively.
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2 a5 U, a. K- I1 t. B* bNow, Glimcher's group shows that the IFNGR but not IL-4R colocalizes with the T cell receptor (TCR) at the immunological synapse. The extent of this colocalization is greatest in mice that tend to generate more Th1 cells. IL-4, which favors production of Th2 cells, inhibits the colocalization.2 ~; D1 ]4 [. ~+ t- v: @
9 H1 X4 D0 \8 m9 b1 N$ a, D1 X5 VTurning this colocalization correlation into causation will take more experiments. For example, cross-linking of the IFNGR and TCR might generate Th1 cells even in the Th2-favoring presence of IL-4. For now, the group points out that colocalization of the two receptors at the synapse puts the IFNGR near the source of its ligand and may set up a positive feedback between activation and differentiation pathways.
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Reference:, Y& b3 B3 M9 f" {4 }" j' h9 W& D
) M7 r h" a6 }# X# G7 [& C" CMaldonado, R.A., et al. 2004. Nature. doi:10.1038/nature02916.(The immunological synapse between T cell) |
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发表于 2009-3-6 08:12
发表于 2015-6-14 16:41
