科學家發現在幹細胞的核纖層蛋白的作用

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科學家已經能夠發現一些線索，有關幹細胞驚人的力量。 根據卡內基的黟縣鄭和陳海陽新的工作，他們已經幫助，識別調節幹細胞小生境影響組織建設和功能可能有潛在的影響，為疾病研究的一個重要組成部分。6 m2 z) V# R) {5 T
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核纖層蛋白，被稱為蛋白質，的主要結構組件的材料，線細胞的細胞核內，具有多樣化的功能，包括抑制基因的表達，並已是相當困難的，以了解如何在他們的突變可導致疾病，以生長在特定的組織和器官，包括骨骼肌肉，心臟肌肉和脂肪。 4 R) x  [" n/ Y; [8 x1 X! }- {
Scientists have been able to uncover some clues regarding the amazing powers of stem cells. According to new work from Carnegie's Yixian Zheng and Haiyang Chen, they've helped identify an important component for regulating stem cell niches that impact on tissue building and function that could have potential implications for disease research.
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Lamins, known as proteins that the major structural component of the material that lines the inside of a cell's nucleus, have diverse functions, including suppressing gene expression and have been rather difficult to understand how mutations in them can cause diseases to grow in specific tissues and organs, including skeletal muscles, heart muscles and fat.; v. d; ^: X0 q  c$ u0 l1 g1 J
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# X, M/ N. I- W/ B/ n7 ~* VBackground information from the study notes that a group of human diseases called laminopathies, which include premature aging, can create defects in proteins called lamins. The study focused on examining whether lamins would link stem cell niche function to healthy tissue building and maintenance.
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To better understand the tissue-specific effects of lamin mutations, the team focused on fruit fly testis-known as one of the best-studied stem cell niche systems. Fruit fly testis, biochemical cross-signaling between the different types of cells that make up the niche environment ensures proper maintenance and differentiation of the testis system's stem cells.# g" C1 [7 \0 @
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By using a technique available in fruit fly studies, the team demonstrated that lamins were a necessary component of supporting niche organization, which can help regulate proper proliferation and differentiation of germline stem cells in fruit fly testis.
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) s5 C0 z, @* K5 ^"These results could have implications for the role of lamins in other types of stem cell niches," Zheng said, via a press release. "These findings could contribute to the study of diseases caused by lamina-based tissue degeneration. For example, different lamin mutations could disrupt the organization of different niches in the body, which then leads to degeneration in tissues."# h0 y) @" m2 s7 M) l( Q

$ m4 p3 h$ x- L9 ^4 RMore information regarding the study can be found in Cell Stem Cell.