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Actin organizer takes pathogens for a ride

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发表于 2009-3-6 08:15 |显示全部帖子
Enteropathogenic E. coli causes a dramatic actin reorganization in intestinal epithelia, erecting intracellular pedestals on the host cells beneath the attached bacteria. On page 407, Campellone et al. reduce this complex phenomenon to twelve amino acids, showing that clustering a small domain of the bacterial Tir protein, which is translocated to the host cell, is sufficient to induce actin rearrangement. The results highlight an interesting evolutionary convergence, and provide a simple model system for studying actin assembly.9 y$ \6 o+ d1 S- q6 a

4 y  e9 B, W0 ZAfter discovering that Tir is the only E. coli component required for pedestal formation, the authors further whittled the system down to the C-terminal cytoplasmic domain of Tir. Clustering this domain at the plasma membrane causes its phosphorylation, allowing it to bind to the host protein Nck. Nck binding leads to the recruitment of N-WASP and the Arp2/3 actin nucleating complex, followed by actin pedestal formation. A 12–amino acid piece of the Tir COOH terminus triggers actin assembly in Xenopus egg extracts. Interestingly, a similar peptide sequence in vaccinia virus allows the virus to be transported on actin tails, suggesting that two unrelated pathogens have evolved to exploit Nck in similar ways. The authors now hope to determine how Nck binding to the Tir sequence leads to actin rearrangement.(Beads covered with a Tir peptide drive a)

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发表于 2015-6-3 09:10 |显示全部帖子
干细胞治疗糖尿病  

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发表于 2015-6-7 13:54 |显示全部帖子
真是天底下好事多多  

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发表于 2015-6-11 14:35 |显示全部帖子
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干细胞存储  

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发表于 2015-6-16 11:26 |显示全部帖子
不错,看看。  

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发表于 2015-6-19 12:33 |显示全部帖子
来上茶~~~~  

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发表于 2015-7-9 18:18 |显示全部帖子
经过你的指点 我还是没找到在哪 ~~~  

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发表于 2015-7-15 08:35 |显示全部帖子
小心大家盯上你哦  

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发表于 2015-7-16 14:18 |显示全部帖子
干细胞行业  

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发表于 2015-7-30 14:01 |显示全部帖子
我是来收集资料滴...  
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