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Rho in podosomes

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发表于 2009-3-6 08:16 |显示全部帖子
Berdeaux, D赤az, and colleagues report that active Rho (Rho) is localized to podosomes in oncogenically transformed cells (page 317). These matrix-digesting, actin-rich, short-lived protrusions help osteoclasts to eat bone and migratory and cancer cells to chew their way through matrix. Their function in Src-transformed cells is now found to rely on Rho activity.) m  G$ ?: i- R4 F9 d7 a

9 ?. e4 w1 q% x3 DRho is known to promote the formation of focal adhesions and actin stress fibers, so the disappearance of stress fibers after transformation with oncogenic Src was presumed to reflect down-regulation of Rho. But Berdeaux et al. report that levels of Rho are not decreased in Src-transformed cells. Instead, focal adhesions and stress fibers may be lost because Src induces a block in signaling downstream of Rho and a loss in cell–matrix adhesion., U, i8 D& r+ k% ]9 @! `% {

, [0 }5 P, e) V. m' xActive Rho is, however, found in Src- induced podosomes. Inhibition of Rho disrupted localization of several proteins to podosomes, and almost completely abolished the secretion of matrix-digesting enzymes. Thus, Rho is necessary to form not only focal adhesions and stress fibers in normal cells but also the more dynamic and transient podosomes characteristic of transformed and tumor cells. The relevant Rho effectors are not known, but Rho may work by recruiting active Src to podosomes or by reorganizing the actin core in these structures. Several of the many signaling proteins in podosomes may, in turn, regulate the localization and activation of Rho.(Active Rho (green) and actin (red) coloc)

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发表于 2015-6-4 22:42 |显示全部帖子
好 好帖 很好帖 确实好帖 少见的好帖  

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发表于 2015-6-13 18:35 |显示全部帖子
dc-cik nk  

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发表于 2015-6-14 23:07 |显示全部帖子
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谢谢干细胞之家提供资料

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发表于 2015-6-17 11:54 |显示全部帖子
先顶后看  

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发表于 2015-8-22 09:26 |显示全部帖子
很有吸引力  

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发表于 2015-9-20 05:33 |显示全部帖子
今天临床的资料更新很多呀

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发表于 2015-10-1 16:10 |显示全部帖子
我的啦嘿嘿  

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发表于 2015-10-22 08:17 |显示全部帖子
楼主福如东海,万寿无疆!  

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发表于 2015-10-24 12:27 |显示全部帖子
你还想说什么啊....  
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