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Death takes a holiday [复制链接]

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楼主
发表于 2009-3-6 08:16 |只看该作者 |倒序浏览 |打印
Montell/Elsevier
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At times, the DIAP-1 anti-apoptotic protein is not what it seems. Erika Geisbrecht and Denise Montell (Johns Hopkins School of Medicine, Baltimore, MD) show that, in the fly ovary, this caspase inhibitor is needed for cell migration but not survival.& w4 x1 v8 U4 r, @

  f& N- e% ^% ?9 v' vMontell's group studies border cells in the fly egg chamber, which migrate to help establish the sperm entry site. Rac activity is needed for this; so to identify more players, the group screened for proteins that restore migration when Rac activity is reduced. They found DIAP-1. Although DIAP-1 is essential for cell survival in the embryo, its loss in the ovary caused migration defects but not cell death.
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Extra actin or profilin, presumably leading to increased actin polymerization, also compensated for the loss of Rac. DIAP-1 may also promote actin polymerization. To block apoptosis, DIAP-1 inhibits the fly caspase-9 homologue, called Dronc. Dronc is probably the DIAP-1 target in border cell migration as well, as reducing its activity suppressed the loss of Rac. Possible Dronc substrates include Rac and actin, which are cleaved by caspases during apoptosis, or profilin.& z9 G) J: Z; ^: I* _. r0 r
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The unexpected identification of DIAP-1 as a suppressor emphasizes the importance of random screens. "The whole point is to find something that you can't even imagine would be involved," says Montell. Tumor cells that manage to increase their levels of DIAP-1–like proteins could gain both a survival advantage and the ability to migrate.$ ~- E+ h' Y, N, U- {4 S8 I* G

) {$ i9 K, H3 dReference:
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7 r8 F$ M3 t' s4 h- j6 w+ eGeisbrecht, E., and D. Montell. 2004. Cell. 118:111–125.(Border cells (arrow) migrate to the wron)

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沙发
发表于 2015-7-2 10:10 |只看该作者
好啊,谢楼主

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藤椅
发表于 2015-7-6 13:28 |只看该作者
严重支持!

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板凳
发表于 2015-7-15 21:10 |只看该作者
干细胞之家微信公众号
生殖干细胞

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报纸
发表于 2015-8-2 14:35 |只看该作者
胚胎干细胞

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地板
发表于 2015-9-4 11:43 |只看该作者
做对的事情比把事情做对重要。  

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发表于 2015-9-6 21:01 |只看该作者
不错的东西  持续关注  

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发表于 2015-9-10 21:15 |只看该作者
回答了那么多,没有加分了,郁闷。。  

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发表于 2015-9-15 08:44 |只看该作者
我顶啊。接着顶  

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发表于 2015-9-28 12:53 |只看该作者
人气还要再提高  
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