PINCHing together integrins and signaling

杨柳

PINCH interacts with integrin-linked kinase and with Nck2, which is involved in regulation of JNK pathway through MAP4 kinase, making it a likely candidate for bridging the two information sources. Using a series of maternal and zygotic mutants, the team found that PINCH was required for proper dorsal closure and that it acted as a negative regulator of the JNK cascade. Moreover, Kadrmas et al. affinity purified a novel PINCH partner RSU-1, a previously identified suppressor of ras-mediated transformation in mammalian cells. PINCH and RSU-1 stabilized one another and were required for proper JNK activity.8 \) ]! n- z. N$ _1 B5 S& B

& H6 O" q; a0 o0 YExactly where in the process of dorsal closure PINCH and RSU-1 are required is the subject of the group's future work. But the current study does imply that integrin-associated junctional complexes may act as signal coordination points, and that JNK signaling must be finely tuned for proper zipping of the epithelial sheet.(Integrin-mediated adhesion and intracell)

大小年

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