Exclusion is spreading

杨柳

Rearrangement is only possible in such huge loci because of DNA contraction and (as shown here) looping that juxtaposes distant DNA sites. Skok and colleagues now show that successful rearrangement is immediately followed by decontraction of the unrearranged allele. Proximal variable (V) regions are still within reach of the rearrangement apparatus, but the products of these rearrangements are disfavored later because they pair poorly with immunoglobulin light chains and usually fail to induce positive selection of cells.
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There is a backup mechanism for allele exclusion. Coincident with decontraction, the unrearranged allele is also recruited to repressive centromeric domains. But Skok says she thinks decontraction "is the most important factor. Decontraction seems to be irreversible and immediate, whereas recruitment is reversible."6 [/ k, v; J+ r+ J8 A

. [/ R# a9 C% K1 [3 E+ qReference:
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& V% e1 g" A7 ~' i* a2 TRoldán, E., et al. 2004. Nat. Immunol. doi:10.1038/ni1150.(Allelic exclusion simplifies the problem)

橙味绿茶

有才的不在少数啊  

biobio

免疫细胞疗法治疗肿瘤有效  

龙水生

加油啊！！！！顶哦!!!!!支持楼主，支持你~  

immail

加油啊！偶一定会追随你左右，偶坚定此贴必然会起到抛砖引玉的作用~  

aakkaa

原来是这样  

依旧随遇而安

来上茶~~~~  

haha3245

哈哈,有意思~顶顶 ，继续顶顶。继续顶哦  

foxok

干细胞存储  

yukun

说的真有道理啊！