2014年4月3日 Nature

nero1981

2014年4月3日 Nature
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Basal mammary tumour cells from a donor mouse (red) expressing a lineage marker (green) comingle with host-derived epithelial cells. The elongated mammary duct on the left retains a normal bilayered architecture in the absence of infiltration by the donor-derived tumour subclone. Tumours often display a complex subclonal organization. In a mouse model of breast cancer initiated by Wnt signalling, Allison Cleary et al. show that some tumours are biclonal — composed of basal and luminal clones with distinct genetic alterations. These clones cooperate to maintain tumour growth that is dependent on secretion of Wnt by the luminal cells. When Wnt production is blocked, basal cells carrying Hras mutations recruit other Wnt-producing cells to restore tumour growth, or one of the original clones may acquire alternative means of activating the pathway. These findings illuminate how complex cellular interactions in heterogeneous tumours might sway treatment outcomes. On the cover, Cover: Thomas Abrahams/Penn State Imaging Core.  F- ?2 B; \. z% U7 ~4 G
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