Small RNAs May Have a Big Role in Embryonic Stem Cells

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# b' i+ C9 R: m. s0 KJeanne F. Loring, PhD, The Scripps Research Institute, La Jolla, CA
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As the human genome is studied in increasing depth, we, Q2 U8 [- \6 e5 z! x) a. {
are beginning to understand that it contains a great deal
$ a4 Y% D9 N1 ^2 j6 Bmore information than is written in the small amount of
+ ^4 v5 Z5 h2 y4 _2 @3 @0 P4 h6 Usequence that codes for proteins. We now know that  j" c+ E  p  w  R4 w
almost all of the genome is actively transcribed, and that$ ~3 \6 c  }: b
the vast majority of RNAs produced appear to be involved in% t1 f. z# E& i0 c
regulating the products of the 2% of the genome that codes7 f: n* a  p! e! z. K6 K
for proteins1. Non-coding RNAs are involved in regulatory1 [6 f- Y# ^6 Q
networks that control gene expression and have been
$ }8 e5 d! S) V! t9 h; k& _implicated in a wide range of biological processes, including
2 E- K; g) ~# n; bembryonic development, evolutionary change, and cell-cell
9 @8 a3 V, j* h3 I$ @, Y+ N) H. Xcommunication. This article touches on recent evidence
# K$ Q5 g- p/ v/ s, y* C: Kthat presages is an important role for non-coding RNAs
4 k& ?: ?  I$ `  F! [0 R/ kin regulating human embryonic stem cell pluripotence and
# `( ^2 t1 a/ Q2 Zdifferentiation.6 {0 w3 |' e1 b: C
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王乾

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have-a-rest

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efool

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zhaichao_1

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sparkleli57

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penghuimin

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scienese

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