Small RNAs May Have a Big Role in Embryonic Stem Cells

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Jeanne F. Loring, PhD, The Scripps Research Institute, La Jolla, CA; O! B0 m9 V) c: P  q( X6 J5 p
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Abstract7 i2 ~& y9 m+ Y6 R# Z7 E5 v" H6 i9 X- }
As the human genome is studied in increasing depth, we
" U! e- h' A' [  }! N- C1 kare beginning to understand that it contains a great deal5 s7 e1 T9 y; {% l- b5 ]
more information than is written in the small amount of
2 y) v0 G6 p& l8 m: g3 x0 C' U* Osequence that codes for proteins. We now know that+ k2 ~+ |5 S) F
almost all of the genome is actively transcribed, and that9 O7 E0 E" y2 x; R7 r3 Y8 P
the vast majority of RNAs produced appear to be involved in8 w- m1 `2 |. t/ p. T) O
regulating the products of the 2% of the genome that codes
3 W4 T* c" P1 r. _* Y! _/ n  ^4 Pfor proteins1. Non-coding RNAs are involved in regulatory
9 @1 }" W! e/ \networks that control gene expression and have been
9 C1 {4 q0 j; `implicated in a wide range of biological processes, including+ i4 ^9 F( _, p, q7 V
embryonic development, evolutionary change, and cell-cell
- u) h, ]) u4 f  a/ l! f7 qcommunication. This article touches on recent evidence
- `" q% h5 N* e4 y* z" E1 Xthat presages is an important role for non-coding RNAs
+ E5 l7 F* l4 y- B. Z+ l' i, ]in regulating human embryonic stem cell pluripotence and
) ^. e$ S- x5 T5 O0 n' `& Ndifferentiation.$ B& g) R7 e2 y* A% J& d3 {

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王乾

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have-a-rest

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zhaichao_1

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sparkleli57

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penghuimin

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scienese

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