Mechanisms of Disease Cancer Stem Cells

richy

Craig T. Jordan, Ph.D., Monica L. Guzman, Ph.D., and Mark Noble, Ph.D.0 S% T, D- b, u' v+ \- ^6 b

  T/ }- a% Z* [, S! w# VThe deepening of our understanding of normal biology has made1 `; V  {) Q" b0 G
it clear that stem cells have a critical role not only in the generation of complex& g7 ~% R$ H2 u. u: A) h
multicellular organisms, but also in the development of tumors. Recent
$ N# E$ j& e$ t! k  ?% s9 nfindings support the concept that cells with the properties of stem cells are integral" ~! l1 |1 l% j' t- `
to the development and perpetuation of several forms of human cancer.1-3 Eradication% j4 O! ~3 d5 |4 M; F! t- q+ W
of the stem-cell compartment of a tumor also may be essential to achieve stable,0 s6 v1 a; D. g" m0 a- M
long-lasting remission, and even a cure, of cancer.4,5 Advances in our knowledge of4 {0 a" i' o. n: c7 m
the properties of stem cells have made specific targeting and eradication of cancer
7 W& m1 M- f2 z$ z% R& G! \3 cstem cells a topic of considerable interest. In this article, we discuss the properties- _3 B6 I! P7 q" S
of cancer stem cells, outline initial therapeutic strategies against them, and present0 Y+ Q, ]0 {; O6 t- _9 [# ^2 Y
challenges for the future.
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efool

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Fischer3

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ahmusht

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Chris

like it
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barton_nyd

好东西，看看啊

yolanda_sea

谢了

hualin840518

很好！

hualin840518

很好！谢谢诶！

15816126

good