Sci Rep：干细胞移植或可恢复机体的感觉功能（附原文）

defu

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6 n; J. D/ ~: d8 b0 Q来源：生物谷 2015-06-09 13:29/ |  M3 t5 M6 s/ u
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2015年6月9日 讯 /生物谷BIOON/ --近日，一篇发表于国际杂志Scientific Reports上的研究论文中，来自瑞典乌普萨拉大学的研究人员通过研究表示，用于治疗脊髓损伤的人类干细胞疗法或可促进机体某些感觉功能的恢复。
3 O. T. N! J9 ?交通事故或严重跌落会引发脊髓中神经纤维的破碎，最为常见的是这些撕脱伤损伤会影响胳膊和手的神经支配，进而导致瘫痪、感觉缺失以及慢性疼痛的发生；外科手术会帮助病人重新获得部分肌肉功能，但目前却没有疗法可以恢复个体的感觉功能，因为破裂的神经纤维和脊髓之间的连接出现了障碍，从而就会抑制神经纤维生长并且恢复缺失的神经连接。
7 c  U; ?6 ]! V8 z3 L1 }& g这项研究中，研究人员将人类干细胞移植到小鼠的撕脱伤伤口处，来恢复从周缘组织到脊髓中的感觉功能；研究结果显示，被移植入的干细胞可以作为一座“桥梁”来促进损伤的感觉神经纤维在脊髓中生长，重建功能性的神经连接，从而恢复缺失的感觉功能。这种移植的干细胞会分化形成对神经系统特殊的不同成熟水平的多种类型的细胞，目前研究者并没有发现干细胞移植后有任何肿瘤发生或功能性异常的迹象，这就为后期研究人员进行胚胎干细胞的移植提供了新的线索。3 g  h- V) N" _2 ^
本文研究或为后期研究者们进行更为深入的研究来利用干细胞疗法治疗脊髓的损伤和疾病，以及开发治疗相关障碍的新型干细胞疗法提供一定的帮助和思路。
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' a2 K0 {" Z# e7 S8 b  t- ?- A4楼原文 感谢WeiTing 提供

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doi:10.1038/srep10666- ]1 n9 h. h0 V! S
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Human Embryonic Stem Cell-Derived Progenitors Assist Functional Sensory Axon Regeneration after Dorsal Root Avulsion Injury : [5 V2 |" m& l! s5 z* K# g# v
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Jan Hoeber, Carl Trolle, Niclas Konig, Zhongwei Du, Alessandro Gallo, Emmanuel Hermans, Hakan Aldskogius, Peter Shortland, Su-Chun Zhang, Ronald Deumens & Elena N. Kozlova, r4 \9 z2 Z8 r) `9 r1 e1 T" W8 U
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& N3 n; j  |  C& U  h% FDorsal root avulsion results in permanent impairment of sensory functions due to disconnection between the peripheral and central nervous system. Improved strategies are therefore needed to reconnect injured sensory neurons with their spinal cord targets in order to achieve functional repair after brachial and lumbosacral plexus avulsion injuries. Here, we show that sensory functions can be restored in the adult mouse if avulsed sensory fibers are bridged with the spinal cord by human neural progenitor (hNP) transplants. Responses to peripheral mechanical sensory stimulation were significantly improved in transplanted animals. Transganglionic tracing showed host sensory axons only in the spinal cord dorsal horn of treated animals. Immunohistochemical analysis confirmed that sensory fibers had grown through the bridge and showed robust survival and differentiation of the transplants. Section of the repaired dorsal roots distal to the transplant completely abolished the behavioral improvement. This demonstrates that hNP transplants promote recovery of sensorimotor functions after dorsal root avulsion, and that these effects are mediated by spinal ingrowth of host sensory axons. These results provide a rationale for the development of novel stem cell-based strategies for functionally useful bridging of the peripheral and central nervous system.
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sunnyhuan0629

这种移植的细胞可分化形成对神经系统特殊的不同成熟水平的多种类型的细胞，也就是说是尚不清晰的混合杂细胞？那恐怕还不能说“没有发现干细胞移植后有任何肿瘤发生或功能性异常的迹象”吧。。。期待后续研究

WeiTing

回复 defu 的帖子
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Human Embryonic Stem Cell-Derived Progenitors Assist Functional Sensory Axon Regeneration after Dorsal Root Avulsion Injury4 g7 }) j" }. |

shamoye

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