READING TIME TOPIC 24

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Today' s topic: Lentiviral vectors: excellent tools for experimental gene transfer and promising candidates for gene therapy
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The summary and the paper is in the attachments.# i. o4 z& d# c; V7 U! G8 n5 v
1 you could try to translate the summary
6 U8 P! K0 a5 M% {. Z0 V2 you could talk about the author or the institute+ Q( `$ |" T. x) v, x/ `: C" K
3 you could summarize steps of the experiment or the results
9 }# E+ v+ e6 `7 {, [4 you could give your doubts of this paper" N- P/ W( b& N; [0 ~8 N. S* q
5 you could upload your record of the summarize
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If you want to talk something else, please let me know.

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Luigi Naldini' \4 N: W4 q5 M7 f# j/ Y7 e! S
Gene Transfer Technologies and new Gene Therapy Strategies
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Somatic gene therapy requires the efficient delivery and sustained expression of therapeutic genes into the tissues of a human body. Such an approach has tremendous therapeutic potential for several inherited and acquired diseases. However, several challenges must be met to fulfill these expectations, starting from the development of more efficient, safe and versatile gene transfer tools.

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introduction) f. U0 P3 S* \( ]: o& g- B! m! W( H
design of lentiviral vectors0 c% z$ ~' L+ W8 R+ o1 {: l
transgen expression by lentiviral vectors3 K( d9 n4 X2 s% I
biosafty of lentiviral vectors
% P! F  t* ^) H: U; c/ onon-primate lentiviral vectors
: h5 x- n. f9 ?8 W7 L6 bgene transfer performance, h, Q( n1 H: {" J+ d% Z# o7 P1 B
conclusions and perspectives# M7 Q3 V* t# K1 Y
reference

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introduction
! q9 M, f' t- `) _+ ddesign of lentiviral vectors
2 y& x& d% p2 Z+ {3 Y0 T, ctransgen expression by lentiviral vectors
* t) r' v3 L. m, v* l: Z& x% m3 Vbiosafty of lentiviral vectors- o% F7 h4 V' ~
non-primate lentiviral vectors
4 A  \3 u! {, x3 q) T, Dgene transfer performance
/ t* ~# F. j% nconclusions and perspectives
8 E! B0 J: L6 Hreference

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摘要
1 d# {' g' p& \9 Y来自于慢病毒的慢病毒载体是转基因实验的工具。慢病毒载体从首次应用到现在，已经在设计，生物安全，在目的细胞中转基因表达能力上有了很大改进。目前可用的灵长类和非灵长类慢病毒载体，应用这两种系统在大量组织中的表达的研究在不断向前推进。这里我们回顾在基因治疗方面潜力的慢病毒体系。

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QUSETION:
2 O3 i- U$ S3 q1 What' s the differences between primate lentiviral vector and nonprimate  lentiviral vector?what are they?" b" x% h) \: F$ a2 U$ K
2 shall we use lentiviral vector in vivo?

windboat

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please join in actively, you can learn a lot.

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来学习下~~~