Transformation from committed progenitor to leukemia stem cells

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Ann N Y Acad Sci. 2009 Sep;1176:144-9. Related Articles, LinkOut : u( y% N/ D7 ^5 U2 t- W( K% h
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Transformation from committed progenitor to leukemia stem cells.+ ]* \1 _" o9 s) H8 x
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Krivtsov AV, Feng Z, Armstrong SA.
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2 c8 H) [- u% d  @. B! G0 CDivision of Hematology/Oncology, Children's Hospital, Department of Pediatric Oncology, Dana Farber Cancer Institute, and Harvard Medical School, Boston, Massachusetts 02215, USA.
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Leukemias are composed of a hierarchy of cells, only a fraction of which have stem cell-like properties and are capable of self-renewal. Mixed lineage leukemia (MLL) fusion proteins produced by translocations involving the MLL gene on chromosome 11q23 confer stem cell-like properties on committed hematopoietic progenitors. This provides an opportunity to assess changes in immunophenotype, gene expression, and epigenetic programs during the transition from a hematopoietic cell with minimal inherent self-renewal capability to cells capable of leukemic self-renewal., e1 P+ s) y. r, |# ?8 d, d

8 p1 }  E. E. I7 A' iPMID: 19796242
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