Transformation from committed progenitor to leukemia stem cells

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Ann N Y Acad Sci. 2009 Sep;1176:144-9. Related Articles, LinkOut , z% s+ J, A& L3 ^) M/ k3 w
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Transformation from committed progenitor to leukemia stem cells.
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Krivtsov AV, Feng Z, Armstrong SA.2 y' n/ D; m; |) `

% a' {, O$ M; G8 T: Z) ZDivision of Hematology/Oncology, Children's Hospital, Department of Pediatric Oncology, Dana Farber Cancer Institute, and Harvard Medical School, Boston, Massachusetts 02215, USA.1 Z( I( n; d! _2 m( i

) D$ E$ i8 m5 T" R" |% P! U( KLeukemias are composed of a hierarchy of cells, only a fraction of which have stem cell-like properties and are capable of self-renewal. Mixed lineage leukemia (MLL) fusion proteins produced by translocations involving the MLL gene on chromosome 11q23 confer stem cell-like properties on committed hematopoietic progenitors. This provides an opportunity to assess changes in immunophenotype, gene expression, and epigenetic programs during the transition from a hematopoietic cell with minimal inherent self-renewal capability to cells capable of leukemic self-renewal.
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PMID: 19796242
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