Transformation from committed progenitor to leukemia stem cells

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Ann N Y Acad Sci. 2009 Sep;1176:144-9. Related Articles, LinkOut
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Transformation from committed progenitor to leukemia stem cells.) L7 {% J5 m* @* g/ O9 W
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Krivtsov AV, Feng Z, Armstrong SA.
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Division of Hematology/Oncology, Children's Hospital, Department of Pediatric Oncology, Dana Farber Cancer Institute, and Harvard Medical School, Boston, Massachusetts 02215, USA.( X+ h8 v1 A7 \- S5 H. s; L

4 z* G4 k: Y2 }, @- yLeukemias are composed of a hierarchy of cells, only a fraction of which have stem cell-like properties and are capable of self-renewal. Mixed lineage leukemia (MLL) fusion proteins produced by translocations involving the MLL gene on chromosome 11q23 confer stem cell-like properties on committed hematopoietic progenitors. This provides an opportunity to assess changes in immunophenotype, gene expression, and epigenetic programs during the transition from a hematopoietic cell with minimal inherent self-renewal capability to cells capable of leukemic self-renewal.
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