microRNA与干细胞

细胞海洋

microRNA，包括miRNA、SiRNA和PiRNA等等。它们是基因表达、修饰、转录和翻译的调节者。近年来的研究证明，microRNA在干细胞的自我复制、定向分化和组织再生中，都起着十分重要的作用。它是干细胞特性、维持、转化功能的一个关键的调节者，是当前干细胞调节研究的一个重点。最近，Gangara Ju. VK和Lin H在Nature Stem Cell作了一篇综述，系统的总结了microRNA对干细胞调节作用
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但是，microRNA对干细胞的调节作用还远远不止于此。它还参与细胞周期、细胞重建(Reprograming)、多能干细胞生成、信号传递、特异分化、Riches、修复、再生、变异、代谢等所有过程

maxiaorongqp

有这部综述的全文吗

细胞海洋

MicroRNA-134 Modulates the Differentiation of Mouse Embryonic Stem Cells, Where It Causes Post-Transcriptional Attenuation of Nanog and LRH1
0 a' B  B* F9 DMicroRNA Regulation of Cell Lineages in Mouse and Human Embryonic Stem Cells
! s$ n6 w' n  u( s% MMicroRNA Regulation of Stem Cell Fate
! C, v/ u0 e! M- m. I( O% C$ k9 JMicroRNA-145 Regulates OCT4, SOX2, and KLF4 and Represses Pluripotency in Human Embryonic Stem Cells
7 V1 G( S3 ?. ^9 v( [/ W5 BMicroRNA-145 to control human embryonic stem cell (hESC) pluripotency and differentiation
& A( u* N# t, O* A+ f! V8 g8 y& _A feedback regulatory loop involving microRNA-9 and nuclear receptor TLX in neural stem cell fate determination
5 ^: x+ r8 v! [5 K/ I/ }  `An embryonic stem cell chromatin remodeling complex, esBAF, is an essential component of the core pluripotency transcriptional network
7 P8 Y4 l9 ?$ K9 X& ]; z9 ?ca-let-7 microRNAs in development, stem cells and cancer 5 V$ _  ~2 H* T* H* R
Ca-Metastasis-from dissemination to organ-specific colonization % a! @, C" f' E9 Y7 y
Cell Cycle Regulation by MicroRNAs in Embryonic Stem Cells
+ q, r$ s/ S4 o) KChromosome instability is common in human cleavage-stage embryos $ ?( D! p  r" u1 L7 \) Y
Comprehensive MicroRNA Profiling Reveals a Unique Human Embryonic Stem Cell , r% v; s; G$ B! }6 q8 H
Connecting microRNA Genes to the Core Transcriptional Regulatory Circuitry of Embryonic Stem Cells
7 u/ W9 c5 K2 v; f4 t0 wDifferentiating human multipotent mesenchymal stromal cells regulate microRNAs
/ K0 _2 K, W: x! ]( IEmbryonic stem cell–specific microRNAs regulate the G1-S transition and promote rapid proliferation 2 c0 z, v1 f1 s$ q
HMGA2, MicroRNAs, and Stem Cell Aging 0 l# h* q- l( H: X* c6 n$ X
Lin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing
4 c: I, W2 A) \1 F' O; z: gLin28 Mediates the Terminal Uridylation of let-7 Precursor MicroRNA
1 N8 g& {9 H# ?& U0 ZLong noncoding RNAs in mouse embryonic stem cell pluripotency and differentiation 2 ]8 I/ x  }3 z) D" H, \8 h" L
MicroRNA-134 Modulates the Differentiation of Mouse Embryonic Stem Cells 0 U9 L  X, d5 X2 t* z6 q2 p2 H
miR-145 in Stem Cell Differentiation - a4 c6 l. h- X$ }: T
MIR-451 and Imatinib mesylate inhibit tumor growth of Glioblastoma stem cells " [& q: p) j% u
miR-9 and TLX-chasing tails in neural stem cells * v, L' g! H' z3 P
Multipotent adult germline stem cells and embryonic stem cells have similar microRNA profiles
5 {+ m) u* L  o3 _5 r1 `. D' W& q. NPluripotent stem cell lines " U" a0 l( j( T4 {
Regulatory circuits underlying pluripotency and reprogramming
' Q4 p* ?7 e, |" Bsc-MicroRNAs to , and coding regions modulate embryonic stem cell differentiation
, A. e$ B$ G7 ~sc-MicroRNAs-key regulators of stem cells ! x6 H5 T/ d6 r5 G  ?2 ~+ G( }
MicroRNA Regulation of Cell Lineages in Mouse and Human Embryonic Stem Cells ( u; P4 m9 O( m, p0 j* {
Stem cells-MicroRNAs promote differentiation
& Y+ s7 i1 u# d7 p0 isc-MicroRNA Expression in Multipotent Mesenchymal Stromal Cells ! s1 M; R$ {7 U2 Z3 x9 W1 L7 |
Stem cells- MicroRNAs promote differentiation 2 U  o- Q' P: v! K0 ~; j+ Q
MicroRNA regulation directs lineage-and developmental stage-specific transgene expression in hematopoietic stem cell progeny

guanjiyu

谢谢分享

fuguangbo

好文章！谢谢！

sacia

好东西~楼主辛苦了！！

ouyi2738

Embryonic stem cell–specific microRNAs promote induced pluripotency

sdyinong

谢谢

yaner

有全文吗

Rainnie

microRNA，包括miRNA、SiRNA和PiRNA等等。它们是基因表达、修饰、转录和翻译的调节者。近年来的研究证明，m ...
' q2 n6 L9 u5 X" }8 i1 V细胞海洋 发表于 2009-10-29 18:58

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   全文有么？