microRNA与干细胞

细胞海洋

microRNA，包括miRNA、SiRNA和PiRNA等等。它们是基因表达、修饰、转录和翻译的调节者。近年来的研究证明，microRNA在干细胞的自我复制、定向分化和组织再生中，都起着十分重要的作用。它是干细胞特性、维持、转化功能的一个关键的调节者，是当前干细胞调节研究的一个重点。最近，Gangara Ju. VK和Lin H在Nature Stem Cell作了一篇综述，系统的总结了microRNA对干细胞调节作用; x9 A/ ^+ N$ ]3 L; w" v  ~

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但是，microRNA对干细胞的调节作用还远远不止于此。它还参与细胞周期、细胞重建(Reprograming)、多能干细胞生成、信号传递、特异分化、Riches、修复、再生、变异、代谢等所有过程

细胞海洋

MicroRNA-134 Modulates the Differentiation of Mouse Embryonic Stem Cells, Where It Causes Post-Transcriptional Attenuation of Nanog and LRH1
0 U( V$ M8 a) }! w% T' nMicroRNA Regulation of Cell Lineages in Mouse and Human Embryonic Stem Cells ( z; c, ?# x2 o4 k
MicroRNA Regulation of Stem Cell Fate & Y# l( W, Y8 T- N
MicroRNA-145 Regulates OCT4, SOX2, and KLF4 and Represses Pluripotency in Human Embryonic Stem Cells
5 e# }7 K$ g, t# U6 E3 Z; U& IMicroRNA-145 to control human embryonic stem cell (hESC) pluripotency and differentiation 5 E. i, x. V4 V) ]  {* w6 p0 C0 D
A feedback regulatory loop involving microRNA-9 and nuclear receptor TLX in neural stem cell fate determination $ h* A! P& N5 D( d/ G3 y6 U
An embryonic stem cell chromatin remodeling complex, esBAF, is an essential component of the core pluripotency transcriptional network
# ]! C! `$ m0 ^8 lca-let-7 microRNAs in development, stem cells and cancer
8 Z2 H3 O: }9 |, `& o/ g! HCa-Metastasis-from dissemination to organ-specific colonization ' R! f! [5 w9 W7 Y, J
Cell Cycle Regulation by MicroRNAs in Embryonic Stem Cells
  q# j( u) O& m$ \6 m+ H# ^Chromosome instability is common in human cleavage-stage embryos
, `4 L$ j% K' D8 }& UComprehensive MicroRNA Profiling Reveals a Unique Human Embryonic Stem Cell   D4 P1 V  `" P, T' v% @6 K
Connecting microRNA Genes to the Core Transcriptional Regulatory Circuitry of Embryonic Stem Cells 7 A- O+ \4 T& Z5 w
Differentiating human multipotent mesenchymal stromal cells regulate microRNAs
6 U% B" A' C7 Q4 [" \6 pEmbryonic stem cell–specific microRNAs regulate the G1-S transition and promote rapid proliferation
0 s/ j5 }8 F4 R- y/ IHMGA2, MicroRNAs, and Stem Cell Aging / Z" U( a* L9 G+ i9 k) N! g
Lin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing
" D: Y, R* A: q( h$ ?Lin28 Mediates the Terminal Uridylation of let-7 Precursor MicroRNA " X0 r7 o( @1 e- p8 m1 g; f7 C
Long noncoding RNAs in mouse embryonic stem cell pluripotency and differentiation 5 Q  b" H: x  e
MicroRNA-134 Modulates the Differentiation of Mouse Embryonic Stem Cells " \* ~: S  _" Y* H6 k
miR-145 in Stem Cell Differentiation - r1 N( z& V8 ^1 G) {. a4 H6 ?$ Z8 [
MIR-451 and Imatinib mesylate inhibit tumor growth of Glioblastoma stem cells
  a) [7 a( C/ H- ^miR-9 and TLX-chasing tails in neural stem cells 6 y5 S9 U. E" O
Multipotent adult germline stem cells and embryonic stem cells have similar microRNA profiles
: R9 T: P$ x8 R  S6 PPluripotent stem cell lines
3 m; u3 U1 Y# @/ o3 e  O+ d2 VRegulatory circuits underlying pluripotency and reprogramming $ U6 s7 o; V' ?1 D- d/ g/ M* Y3 D2 R
sc-MicroRNAs to , and coding regions modulate embryonic stem cell differentiation ) |4 G& U7 X; [  @
sc-MicroRNAs-key regulators of stem cells ( p( ~6 g9 \& g# Y
MicroRNA Regulation of Cell Lineages in Mouse and Human Embryonic Stem Cells
$ q% o2 L# p( J! L0 |' X0 f  A3 fStem cells-MicroRNAs promote differentiation - S4 J. a8 Q: M" O# e; P
sc-MicroRNA Expression in Multipotent Mesenchymal Stromal Cells 4 K  w  Z/ p5 U* d2 }$ P9 j
Stem cells- MicroRNAs promote differentiation * \8 C, B6 ^. i- b$ D" o  G6 H
MicroRNA regulation directs lineage-and developmental stage-specific transgene expression in hematopoietic stem cell progeny