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[讨论] microRNA与干细胞     [复制链接]

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楼主
发表于 2009-10-29 18:58 |只看该作者 |倒序浏览 |打印
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microRNA,包括miRNA、SiRNA和PiRNA等等。它们是基因表达、修饰、转录和翻译的调节者。近年来的研究证明,microRNA在干细胞的自我复制、定向分化和组织再生中,都起着十分重要的作用。它是干细胞特性、维持、转化功能的一个关键的调节者,是当前干细胞调节研究的一个重点。最近,Gangara Ju. VK和Lin H在Nature Stem Cell作了一篇综述,系统的总结了microRNA对干细胞调节作用) ^" d8 \8 R: b8 Y/ r: X. S- u' ]! [

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) n0 J$ w& o* E, J' A$ \& U* u但是,microRNA对干细胞的调节作用还远远不止于此。它还参与细胞周期、细胞重建(Reprograming)、多能干细胞生成、信号传递、特异分化、Riches、修复、再生、变异、代谢等所有过程

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沙发
发表于 2009-10-29 23:50 |只看该作者
有这部综述的全文吗

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藤椅
发表于 2009-10-30 08:19 |只看该作者
MicroRNA-134 Modulates the Differentiation of Mouse Embryonic Stem Cells, Where It Causes Post-Transcriptional Attenuation of Nanog and LRH1
/ c, ^3 @, J9 D! a6 s" S+ O1 LMicroRNA Regulation of Cell Lineages in Mouse and Human Embryonic Stem Cells 1 N' ?9 W: s0 @+ M: G0 h/ K
MicroRNA Regulation of Stem Cell Fate
8 C6 {" _" U, e0 cMicroRNA-145 Regulates OCT4, SOX2, and KLF4 and Represses Pluripotency in Human Embryonic Stem Cells
) Q0 r. E" e8 F9 ]MicroRNA-145 to control human embryonic stem cell (hESC) pluripotency and differentiation
; M+ w8 r7 N0 qA feedback regulatory loop involving microRNA-9 and nuclear receptor TLX in neural stem cell fate determination
5 b1 M1 }% {) ^  ]/ B: gAn embryonic stem cell chromatin remodeling complex, esBAF, is an essential component of the core pluripotency transcriptional network 7 ?4 v: b7 {; ]1 h% u: h+ m1 ^" X
ca-let-7 microRNAs in development, stem cells and cancer
8 M$ p2 r( V/ Q( a+ QCa-Metastasis-from dissemination to organ-specific colonization 7 t4 o# s6 }& Y- j; u# N
Cell Cycle Regulation by MicroRNAs in Embryonic Stem Cells
! u( M) |- Y6 l/ p8 v  qChromosome instability is common in human cleavage-stage embryos 6 k4 E7 c9 d3 d# b5 N& O8 z0 _
Comprehensive MicroRNA Profiling Reveals a Unique Human Embryonic Stem Cell
% N4 x* F8 [  p- [; V0 VConnecting microRNA Genes to the Core Transcriptional Regulatory Circuitry of Embryonic Stem Cells
1 j. u6 E7 L$ @. D" yDifferentiating human multipotent mesenchymal stromal cells regulate microRNAs
3 G! @0 n; `$ C& d; }* A% p: a/ ~Embryonic stem cell–specific microRNAs regulate the G1-S transition and promote rapid proliferation
8 d9 J4 y$ R. |8 ^4 ?! m( L. m! ZHMGA2, MicroRNAs, and Stem Cell Aging / r* ]% ~+ J* p7 z2 {5 J
Lin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing % G: W- K, Q+ f7 F( p
Lin28 Mediates the Terminal Uridylation of let-7 Precursor MicroRNA $ H* i' k0 V7 Z& }- _( d
Long noncoding RNAs in mouse embryonic stem cell pluripotency and differentiation
9 a/ e" K' f7 {8 N/ D! f8 L9 TMicroRNA-134 Modulates the Differentiation of Mouse Embryonic Stem Cells 3 h. s' \' R6 `! X+ z! O+ T
miR-145 in Stem Cell Differentiation " w+ K/ ~' O0 I
MIR-451 and Imatinib mesylate inhibit tumor growth of Glioblastoma stem cells
& S# I" X+ G% @5 @# I! OmiR-9 and TLX-chasing tails in neural stem cells
9 B" Y: s$ c, t* U. m1 GMultipotent adult germline stem cells and embryonic stem cells have similar microRNA profiles 8 G2 v8 P: N7 J4 H* V- G
Pluripotent stem cell lines
9 V# P$ v0 M* J6 Z' GRegulatory circuits underlying pluripotency and reprogramming , N$ ?$ a( i& n: A! s9 W+ U& \
sc-MicroRNAs to , and coding regions modulate embryonic stem cell differentiation
1 B1 H  x8 u* P+ {) dsc-MicroRNAs-key regulators of stem cells
- J, }0 c1 b; }8 l2 R- |# ~5 u1 b5 QMicroRNA Regulation of Cell Lineages in Mouse and Human Embryonic Stem Cells
# Q( C9 S6 s' kStem cells-MicroRNAs promote differentiation
" `$ a2 j; h) M/ p2 v2 y$ Fsc-MicroRNA Expression in Multipotent Mesenchymal Stromal Cells - o" |! Q5 I) \4 A$ Y
Stem cells- MicroRNAs promote differentiation 9 e. }. c: f# Z! M
MicroRNA regulation directs lineage-and developmental stage-specific transgene expression in hematopoietic stem cell progeny

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板凳
发表于 2009-10-30 18:56 |只看该作者
谢谢分享

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报纸
发表于 2009-11-9 17:29 |只看该作者
好文章!谢谢!

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地板
发表于 2009-11-27 21:46 |只看该作者
好东西~楼主辛苦了!!

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7楼
发表于 2009-11-27 22:03 |只看该作者
Embryonic stem cell–specific microRNAs promote induced pluripotency

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8楼
发表于 2009-12-2 20:35 |只看该作者
谢谢

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9楼
发表于 2009-12-4 09:52 |只看该作者
有全文吗

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10楼
发表于 2009-12-9 18:39 |只看该作者
microRNA,包括miRNA、SiRNA和PiRNA等等。它们是基因表达、修饰、转录和翻译的调节者。近年来的研究证明,m ...( ~# F6 w9 R8 Q6 {" C. O* R
细胞海洋 发表于 2009-10-29 18:58

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