microRNA与干细胞

细胞海洋

microRNA，包括miRNA、SiRNA和PiRNA等等。它们是基因表达、修饰、转录和翻译的调节者。近年来的研究证明，microRNA在干细胞的自我复制、定向分化和组织再生中，都起着十分重要的作用。它是干细胞特性、维持、转化功能的一个关键的调节者，是当前干细胞调节研究的一个重点。最近，Gangara Ju. VK和Lin H在Nature Stem Cell作了一篇综述，系统的总结了microRNA对干细胞调节作用
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' A/ `+ h+ _) l- w2 v% ?% [; d但是，microRNA对干细胞的调节作用还远远不止于此。它还参与细胞周期、细胞重建(Reprograming)、多能干细胞生成、信号传递、特异分化、Riches、修复、再生、变异、代谢等所有过程

maxiaorongqp

有这部综述的全文吗

细胞海洋

MicroRNA-134 Modulates the Differentiation of Mouse Embryonic Stem Cells, Where It Causes Post-Transcriptional Attenuation of Nanog and LRH1
1 a7 |2 B- E+ X/ u& ~MicroRNA Regulation of Cell Lineages in Mouse and Human Embryonic Stem Cells * C! [0 r/ e: G9 Z; _5 q
MicroRNA Regulation of Stem Cell Fate
% D+ o' y8 {- U! zMicroRNA-145 Regulates OCT4, SOX2, and KLF4 and Represses Pluripotency in Human Embryonic Stem Cells
/ U+ y- @! g1 D/ U+ @MicroRNA-145 to control human embryonic stem cell (hESC) pluripotency and differentiation
5 s8 n1 S% V! D* m% |/ X1 rA feedback regulatory loop involving microRNA-9 and nuclear receptor TLX in neural stem cell fate determination
" e! }/ W# o/ |- H& i2 D; KAn embryonic stem cell chromatin remodeling complex, esBAF, is an essential component of the core pluripotency transcriptional network & Y( e+ h2 i" W9 ]
ca-let-7 microRNAs in development, stem cells and cancer - n8 {! R0 K2 @
Ca-Metastasis-from dissemination to organ-specific colonization 5 o4 X0 y0 o6 ~' L
Cell Cycle Regulation by MicroRNAs in Embryonic Stem Cells
  g. _, ?$ K: q2 A+ Z9 E- UChromosome instability is common in human cleavage-stage embryos , D7 S$ M  [+ q
Comprehensive MicroRNA Profiling Reveals a Unique Human Embryonic Stem Cell
4 p* w5 R" \7 I; a& kConnecting microRNA Genes to the Core Transcriptional Regulatory Circuitry of Embryonic Stem Cells
6 u  [4 c7 Y8 j3 dDifferentiating human multipotent mesenchymal stromal cells regulate microRNAs + w5 k4 X. Z! D2 F  L; @
Embryonic stem cell–specific microRNAs regulate the G1-S transition and promote rapid proliferation
: K9 R8 I+ e5 _* b. H& w9 MHMGA2, MicroRNAs, and Stem Cell Aging
) s3 g( s% s. x" z1 g# ]& G1 H" yLin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing
# t+ x( d) H4 s/ ULin28 Mediates the Terminal Uridylation of let-7 Precursor MicroRNA
+ O* j# t4 D& J5 Y  h+ h, Q6 U6 dLong noncoding RNAs in mouse embryonic stem cell pluripotency and differentiation * n: p2 \% r  K3 Z5 J
MicroRNA-134 Modulates the Differentiation of Mouse Embryonic Stem Cells 6 J$ e' T" x8 X/ e
miR-145 in Stem Cell Differentiation
, C( ]6 E. c; S  q/ `8 s: lMIR-451 and Imatinib mesylate inhibit tumor growth of Glioblastoma stem cells
+ ]- [$ S- J% I" @2 ymiR-9 and TLX-chasing tails in neural stem cells 2 F, S" c3 k# p/ c: F* t( _
Multipotent adult germline stem cells and embryonic stem cells have similar microRNA profiles
/ {' p; K$ Z, |; j2 u- E* ?Pluripotent stem cell lines ' Q" W7 |7 _# t! {# {+ f1 v! H8 O
Regulatory circuits underlying pluripotency and reprogramming
3 [0 e; I2 T# F% O2 G% J# g' Fsc-MicroRNAs to , and coding regions modulate embryonic stem cell differentiation   u0 T: k" B* R+ b- D
sc-MicroRNAs-key regulators of stem cells " c& T$ ?' ]6 |3 u7 l
MicroRNA Regulation of Cell Lineages in Mouse and Human Embryonic Stem Cells + o6 t5 S1 T% j$ Z
Stem cells-MicroRNAs promote differentiation , e- K7 N& Z! }3 a: d- W+ g
sc-MicroRNA Expression in Multipotent Mesenchymal Stromal Cells
- z$ `8 T! F2 k' r% I' |5 z! IStem cells- MicroRNAs promote differentiation / D, R' S* r6 x' h2 n' x! d
MicroRNA regulation directs lineage-and developmental stage-specific transgene expression in hematopoietic stem cell progeny

guanjiyu

谢谢分享

fuguangbo

好文章！谢谢！

sacia

好东西~楼主辛苦了！！

ouyi2738

Embryonic stem cell–specific microRNAs promote induced pluripotency

sdyinong

谢谢

yaner

有全文吗

Rainnie

microRNA，包括miRNA、SiRNA和PiRNA等等。它们是基因表达、修饰、转录和翻译的调节者。近年来的研究证明，m ...
  s, m% f$ E6 y* }2 J0 X/ v2 P细胞海洋 发表于 2009-10-29 18:58

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   全文有么？