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[讨论] microRNA与干细胞     [复制链接]

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楼主
发表于 2009-10-29 18:58 |只看该作者 |倒序浏览 |打印
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microRNA,包括miRNA、SiRNA和PiRNA等等。它们是基因表达、修饰、转录和翻译的调节者。近年来的研究证明,microRNA在干细胞的自我复制、定向分化和组织再生中,都起着十分重要的作用。它是干细胞特性、维持、转化功能的一个关键的调节者,是当前干细胞调节研究的一个重点。最近,Gangara Ju. VK和Lin H在Nature Stem Cell作了一篇综述,系统的总结了microRNA对干细胞调节作用, g: W% ^; W( g0 E8 g/ @( h

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" q4 @) c" H7 x1 \  |$ `" T4 S但是,microRNA对干细胞的调节作用还远远不止于此。它还参与细胞周期、细胞重建(Reprograming)、多能干细胞生成、信号传递、特异分化、Riches、修复、再生、变异、代谢等所有过程

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沙发
发表于 2009-10-29 23:50 |只看该作者
有这部综述的全文吗

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藤椅
发表于 2009-10-30 08:19 |只看该作者
MicroRNA-134 Modulates the Differentiation of Mouse Embryonic Stem Cells, Where It Causes Post-Transcriptional Attenuation of Nanog and LRH1   {* V0 \: {: b# n' Y) f8 j
MicroRNA Regulation of Cell Lineages in Mouse and Human Embryonic Stem Cells
0 r3 r' e* ?4 {- kMicroRNA Regulation of Stem Cell Fate 7 H8 Z) v' m2 Y; Y% t! d& O
MicroRNA-145 Regulates OCT4, SOX2, and KLF4 and Represses Pluripotency in Human Embryonic Stem Cells
/ d6 m$ j# d* |/ rMicroRNA-145 to control human embryonic stem cell (hESC) pluripotency and differentiation   u  l& [# R0 t) M
A feedback regulatory loop involving microRNA-9 and nuclear receptor TLX in neural stem cell fate determination - s$ M5 R" `# n7 l# g' L8 [: u5 S
An embryonic stem cell chromatin remodeling complex, esBAF, is an essential component of the core pluripotency transcriptional network $ L9 W/ A9 C0 q" B+ f
ca-let-7 microRNAs in development, stem cells and cancer
+ B* p) g3 I  ]; RCa-Metastasis-from dissemination to organ-specific colonization
9 H; e7 I9 h2 ?+ f9 jCell Cycle Regulation by MicroRNAs in Embryonic Stem Cells ' |& o' Q0 b- \$ _+ M- n9 l! s! e
Chromosome instability is common in human cleavage-stage embryos
( j+ ~8 f8 T) N8 h5 }4 ]% rComprehensive MicroRNA Profiling Reveals a Unique Human Embryonic Stem Cell
1 @+ g7 \5 ^. l  X: j6 }; ?, bConnecting microRNA Genes to the Core Transcriptional Regulatory Circuitry of Embryonic Stem Cells
# p2 P9 u7 @" z- G7 f3 Y: E6 E, wDifferentiating human multipotent mesenchymal stromal cells regulate microRNAs " o2 V( |! y' ?) S: O
Embryonic stem cell–specific microRNAs regulate the G1-S transition and promote rapid proliferation
$ n( n; V) n2 T; KHMGA2, MicroRNAs, and Stem Cell Aging
- {& {6 I" [* L  |  N  b! ~  o4 f6 ELin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing
0 M! o" l* @+ y$ |+ h; Y  bLin28 Mediates the Terminal Uridylation of let-7 Precursor MicroRNA
  P; N* J" E! ^# L7 }$ MLong noncoding RNAs in mouse embryonic stem cell pluripotency and differentiation
8 ]2 t% C; j8 K. J. RMicroRNA-134 Modulates the Differentiation of Mouse Embryonic Stem Cells
+ h/ c. v$ Q( w: `) h: ?miR-145 in Stem Cell Differentiation
) t2 y8 ]9 _  \- r4 C4 R3 f% ZMIR-451 and Imatinib mesylate inhibit tumor growth of Glioblastoma stem cells ) h: o. _& z1 U3 E
miR-9 and TLX-chasing tails in neural stem cells 6 k: f7 T" F8 b* Q# W9 @4 G& O
Multipotent adult germline stem cells and embryonic stem cells have similar microRNA profiles ; D' ^2 G% M  T: u/ }7 h. A
Pluripotent stem cell lines 3 r! x7 z; u8 r- N. y8 r2 V- o, N/ c9 O
Regulatory circuits underlying pluripotency and reprogramming
0 \) w, N  v) y$ P7 f  e1 N7 f8 e! psc-MicroRNAs to , and coding regions modulate embryonic stem cell differentiation   {5 S8 ?8 ]1 }& y$ D" |- F
sc-MicroRNAs-key regulators of stem cells - I6 l+ E& r; z8 }; d' g* \2 \5 U
MicroRNA Regulation of Cell Lineages in Mouse and Human Embryonic Stem Cells
* A* _: D/ m& pStem cells-MicroRNAs promote differentiation
! x# ~: t1 c6 h) D" Isc-MicroRNA Expression in Multipotent Mesenchymal Stromal Cells 9 u# _2 N5 u$ c5 }; p9 ?
Stem cells- MicroRNAs promote differentiation
# B/ Y9 S* S, _/ \9 |: rMicroRNA regulation directs lineage-and developmental stage-specific transgene expression in hematopoietic stem cell progeny

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板凳
发表于 2009-10-30 18:56 |只看该作者
谢谢分享

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报纸
发表于 2009-11-9 17:29 |只看该作者
好文章!谢谢!

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地板
发表于 2009-11-27 21:46 |只看该作者
好东西~楼主辛苦了!!

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7楼
发表于 2009-11-27 22:03 |只看该作者
Embryonic stem cell–specific microRNAs promote induced pluripotency

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8楼
发表于 2009-12-2 20:35 |只看该作者
谢谢

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9楼
发表于 2009-12-4 09:52 |只看该作者
有全文吗

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10楼
发表于 2009-12-9 18:39 |只看该作者
microRNA,包括miRNA、SiRNA和PiRNA等等。它们是基因表达、修饰、转录和翻译的调节者。近年来的研究证明,m ...$ o2 D5 b7 J2 A2 e! a5 r; d. \
细胞海洋 发表于 2009-10-29 18:58
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   全文有么?
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