microRNA与干细胞

细胞海洋

microRNA，包括miRNA、SiRNA和PiRNA等等。它们是基因表达、修饰、转录和翻译的调节者。近年来的研究证明，microRNA在干细胞的自我复制、定向分化和组织再生中，都起着十分重要的作用。它是干细胞特性、维持、转化功能的一个关键的调节者，是当前干细胞调节研究的一个重点。最近，Gangara Ju. VK和Lin H在Nature Stem Cell作了一篇综述，系统的总结了microRNA对干细胞调节作用9 r; l! v* t9 J8 w- J( e5 e& H

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( i6 W3 f( s+ j+ w7 p( o0 S( l但是，microRNA对干细胞的调节作用还远远不止于此。它还参与细胞周期、细胞重建(Reprograming)、多能干细胞生成、信号传递、特异分化、Riches、修复、再生、变异、代谢等所有过程

maxiaorongqp

有这部综述的全文吗

细胞海洋

MicroRNA-134 Modulates the Differentiation of Mouse Embryonic Stem Cells, Where It Causes Post-Transcriptional Attenuation of Nanog and LRH1
' e. N- y- O' ]; B( ~+ VMicroRNA Regulation of Cell Lineages in Mouse and Human Embryonic Stem Cells * q/ b9 x9 h0 ]9 I" B. e: ?! m
MicroRNA Regulation of Stem Cell Fate # L5 i- B/ k6 O4 g3 ]
MicroRNA-145 Regulates OCT4, SOX2, and KLF4 and Represses Pluripotency in Human Embryonic Stem Cells 4 j' \; z8 e+ c4 j+ s
MicroRNA-145 to control human embryonic stem cell (hESC) pluripotency and differentiation
" \2 q3 v  ^. D2 MA feedback regulatory loop involving microRNA-9 and nuclear receptor TLX in neural stem cell fate determination
& H$ Y4 N6 {+ z) NAn embryonic stem cell chromatin remodeling complex, esBAF, is an essential component of the core pluripotency transcriptional network
) x  m1 ]- H  Q; e8 T: g( bca-let-7 microRNAs in development, stem cells and cancer ) H1 u2 l! z4 u6 a  o, X9 `3 t6 y
Ca-Metastasis-from dissemination to organ-specific colonization   W9 z+ l8 Q- \3 R4 Y
Cell Cycle Regulation by MicroRNAs in Embryonic Stem Cells 8 H" ^- f" B) W. U, T
Chromosome instability is common in human cleavage-stage embryos ) {$ ~0 k- ]& b. [3 `4 H
Comprehensive MicroRNA Profiling Reveals a Unique Human Embryonic Stem Cell
6 u! J4 p9 x7 {' G9 SConnecting microRNA Genes to the Core Transcriptional Regulatory Circuitry of Embryonic Stem Cells
# J1 T6 A. d+ bDifferentiating human multipotent mesenchymal stromal cells regulate microRNAs ( l6 G6 H( ]! |
Embryonic stem cell–specific microRNAs regulate the G1-S transition and promote rapid proliferation , d) F& W+ x' {; Q' z
HMGA2, MicroRNAs, and Stem Cell Aging
% ^. r$ M( c* \6 B8 [Lin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing , U+ C) K; j6 k9 ]
Lin28 Mediates the Terminal Uridylation of let-7 Precursor MicroRNA 2 \' C6 t. y  h1 b8 a* f+ F
Long noncoding RNAs in mouse embryonic stem cell pluripotency and differentiation
/ Y. Y4 ]  W" DMicroRNA-134 Modulates the Differentiation of Mouse Embryonic Stem Cells & P! i2 ^4 ?; s5 ^) i+ S+ i
miR-145 in Stem Cell Differentiation & h+ y, I" m! v3 A' ~8 m
MIR-451 and Imatinib mesylate inhibit tumor growth of Glioblastoma stem cells ! q  Z# u. V/ `4 C5 p  ]
miR-9 and TLX-chasing tails in neural stem cells ) Y) W6 D2 o/ F7 @; A3 N# {- e, C( M
Multipotent adult germline stem cells and embryonic stem cells have similar microRNA profiles : w! |5 S4 g+ n# @) t; }9 D
Pluripotent stem cell lines
1 V: P, Y4 {$ eRegulatory circuits underlying pluripotency and reprogramming
$ h! ]6 s' `! V  b! T% J/ vsc-MicroRNAs to , and coding regions modulate embryonic stem cell differentiation
7 T. Z* u: U4 _  K/ ]6 Hsc-MicroRNAs-key regulators of stem cells
$ b: B) g) ]6 S* [MicroRNA Regulation of Cell Lineages in Mouse and Human Embryonic Stem Cells ' {4 [4 t) \# D. l4 [, ~- c4 d% o
Stem cells-MicroRNAs promote differentiation ; f0 c7 ]( Q% L
sc-MicroRNA Expression in Multipotent Mesenchymal Stromal Cells 4 k( h' n5 R0 B6 Q, c% i$ J
Stem cells- MicroRNAs promote differentiation
3 x% C: P2 h2 N/ [0 }2 X/ \MicroRNA regulation directs lineage-and developmental stage-specific transgene expression in hematopoietic stem cell progeny

guanjiyu

谢谢分享

fuguangbo

好文章！谢谢！

sacia

好东西~楼主辛苦了！！

ouyi2738

Embryonic stem cell–specific microRNAs promote induced pluripotency

sdyinong

谢谢

yaner

有全文吗

Rainnie

microRNA，包括miRNA、SiRNA和PiRNA等等。它们是基因表达、修饰、转录和翻译的调节者。近年来的研究证明，m ...
, P) P* x8 L+ r/ G细胞海洋 发表于 2009-10-29 18:58

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) z' e- M( V1 j9 T5 x3 I$ x   全文有么？