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最近研究表明,以往认为不能再生的神经组织仍然包含神经干细胞, 而且神经干细胞有更大的可塑性和分化潜能,如:神经干细胞移植是修复神经功能受损的有效方法;它还可能作为一种“有前途的”脑癌治疗新手段,根除手术后残留的肿瘤;除此之外,神经干细胞的功能还可延伸到药物检测方面,对判断药物有效性、毒性有一定的作用。然而对神经干细胞的研究才刚刚起步,尚有许多关键性问题尚未解决。但我们相信不久的将来人类的神经干细胞将有望用于临床作为脑移植的供体细胞以及基因治疗的载体。而其增殖和定向诱导分化机制的最终阐明将有赖于分子生物学、发育生物学等生物学科的相互协作和研究方法的进一步完善。
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% ]2 G8 w1 E% `; W5 t" ?: z2 E. ]Identifying And Tracking Neural Stem Cells
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Marrow Stromal Cells, Mitosis, And Neuronal Differentiation-Stem Cell And Precursor Functions
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/ p3 p" U5 ?3 k/ z# \- {4 _Diclofenac Inhibits Proliferation And Differentiation Of Neural Stem Cells) [! T Q) E: c2 j2 z
' r, ~7 w$ t+ v( f+ |" D# o2 R6 JThe Stem-Cell Menagerie
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Neural Progenitor Cells Lack Immunogenicity And Resist Destruction As Allografts
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Transcriptional Profiling Of Neuronal Differentiation By Human Embryonal Carcinoma Stem Cells In Vitro# ?& {& r9 x( F) K' P' y; Z+ o
5 t+ L8 }: Q/ A$ }$ IRapid method for culturing embryonic neuron-glial cell cocultures
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Neural stem cells and cholinergic neurons
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Identification and isolation of multipotential neural progenitor cells from human brain0 }, O. U: R% @8 ?0 c
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Transplanted neuronal progenitor cells in a peripheral nerve gap promote nerve repair
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0 Z" M1 Y" E/ e9 @$ TEGF-responsive rat neural stem cells0 _/ U. `2 h+ t" n
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Neural stem cells and neuro-oncology$ I+ V4 z0 o4 Q0 B* W! b) X* ~
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What are the characteristics of cycling cells in the adult central nervous system
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Somatic plasticity of neural stem cells5 ~# u. M1 H9 V
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Copernican stem cells-Regulatory constellations in adult hippocampal neurogenesis# C2 O1 J% q# @: c# G
! G$ Z; w+ n- ?6 n% oNeural stem cells in aging and disease
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Transdifferentiation-fact or artifact" h% G9 }8 e/ W
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Identification and isolation of multipotential neural progenitor cells from the subcortical white matter of the adult human brain. |% s& o( o: Z. c
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PTEN regulation of neural development and CNS stem cells
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Neural progenitor cells resist excitatory amino acid-induced neurotoxicity
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Tumor suppressor gene BRCA-1 is expressed by embryonic and adult neural stem cells
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; c# |' \" q. q$ ]Transplanted bone marrow generates new neurons in human brains
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Neural stem cells and neuro-oncology
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9 ~! A9 Y, D/ g/ l: IWhat are the characteristics of cycling cells in the adult central nervous system( E/ D5 ]- ?( X/ _8 J' C
& j% G$ A ]9 ?/ |: n" R& _! d; KNeural stem cells
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. }5 k9 q0 ~' L' c9 j2 GPTEN regulation of neural development and CNS stem cells& s( L; v* D# f L) P% ?$ S- W9 q
+ E7 F7 h! m' N, s! N1 fSomatic plasticity of neural stem cells
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# _8 t# G" V- k0 s+ {2 r/ x4 zTransdifferentiation-fact or artifact# Z9 A1 H6 Y: E2 J) s
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Copernican stem cells
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: l2 j; ] a3 s5 x- ?Contribution of transplanted bone marrow cells to Purkinje neurons in human adult brains$ k, S$ F- W* h! E
& K! B, h" p7 c- O1 G, x7 WSonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo
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- i( |8 Y0 y& G+ d zTransplantation of neural stem cells in a rat model of stroke
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1 J" E. ?7 O+ C7 G8 b9 [1 v" BA Subset of ES-Cell-Derived Neural Cells Marked by Gene Targeting$ ?8 `* M+ c" w1 }- i2 l4 C3 t. U
- b7 q+ | }! n7 q, yMatrix Cells from Wharton’s Jelly Form Neurons and Glia |
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