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最近研究表明,以往认为不能再生的神经组织仍然包含神经干细胞, 而且神经干细胞有更大的可塑性和分化潜能,如:神经干细胞移植是修复神经功能受损的有效方法;它还可能作为一种“有前途的”脑癌治疗新手段,根除手术后残留的肿瘤;除此之外,神经干细胞的功能还可延伸到药物检测方面,对判断药物有效性、毒性有一定的作用。然而对神经干细胞的研究才刚刚起步,尚有许多关键性问题尚未解决。但我们相信不久的将来人类的神经干细胞将有望用于临床作为脑移植的供体细胞以及基因治疗的载体。而其增殖和定向诱导分化机制的最终阐明将有赖于分子生物学、发育生物学等生物学科的相互协作和研究方法的进一步完善。
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/ L5 j% X' H' b+ l# v- a7 SIdentifying And Tracking Neural Stem Cells! f6 E. r0 A5 L3 b |! d
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Marrow Stromal Cells, Mitosis, And Neuronal Differentiation-Stem Cell And Precursor Functions7 I) X5 ~5 E( O/ \2 V% y
; w0 L; R @' @8 l4 ADiclofenac Inhibits Proliferation And Differentiation Of Neural Stem Cells3 u& V4 j; Y* u) ?& j4 E9 @8 g
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The Stem-Cell Menagerie
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7 H: N$ N8 y/ C- z. s$ [% L) ]Neural Progenitor Cells Lack Immunogenicity And Resist Destruction As Allografts
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+ X& n; B& D5 GTranscriptional Profiling Of Neuronal Differentiation By Human Embryonal Carcinoma Stem Cells In Vitro* {8 z+ Y7 e7 }. q: }' B. O7 {4 t
2 `3 S/ N. J8 q0 s# d, IRapid method for culturing embryonic neuron-glial cell cocultures
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! O) o( ?9 \# G. u2 _/ sNeural stem cells and cholinergic neurons* V& |: \4 B, T/ e
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Identification and isolation of multipotential neural progenitor cells from human brain
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Transplanted neuronal progenitor cells in a peripheral nerve gap promote nerve repair
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EGF-responsive rat neural stem cells
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- ?; ]1 G# j7 a4 @& j0 qNeural stem cells and neuro-oncology
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: d3 c/ @0 [. l& F" L }What are the characteristics of cycling cells in the adult central nervous system4 s1 n7 a5 ~6 H7 P! j* f C
' K2 Y3 `$ o6 RSomatic plasticity of neural stem cells' Q, \" f$ T9 G9 h4 [8 R6 g# g
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Copernican stem cells-Regulatory constellations in adult hippocampal neurogenesis' t+ G$ G; e+ {9 l! M1 W
7 w2 q' L0 M( _# [( p0 b, h4 kNeural stem cells in aging and disease
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* F* j0 C) p- x0 w3 eTransdifferentiation-fact or artifact6 V' D$ T, c. U+ q
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Identification and isolation of multipotential neural progenitor cells from the subcortical white matter of the adult human brain' M& y" P3 | d& H8 L! T, R
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PTEN regulation of neural development and CNS stem cells
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6 o L' X. P6 z0 D: ~- v8 d- ^% sNeural progenitor cells resist excitatory amino acid-induced neurotoxicity) _& D9 O H3 V7 {) Z
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Tumor suppressor gene BRCA-1 is expressed by embryonic and adult neural stem cells6 @. ]$ ~- a2 `$ g. z
. ] f& \ r5 [- M2 E+ NTransplanted bone marrow generates new neurons in human brains" D i4 O, G: e/ ]- f6 l
9 O! }% \- L. @: L7 T8 A$ C) p% ZNeural stem cells and neuro-oncology' f7 x: [, ?6 f
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What are the characteristics of cycling cells in the adult central nervous system
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Neural stem cells
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PTEN regulation of neural development and CNS stem cells
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+ |/ ~4 z1 J- j* P% gSomatic plasticity of neural stem cells
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Transdifferentiation-fact or artifact7 |- }' a9 g- Y! i/ _
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Copernican stem cells
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$ c# j: Q7 H. d( N: uContribution of transplanted bone marrow cells to Purkinje neurons in human adult brains
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" |' f& G" e; XSonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo
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Transplantation of neural stem cells in a rat model of stroke/ d/ u' a- p. Y: ~/ x
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A Subset of ES-Cell-Derived Neural Cells Marked by Gene Targeting: U9 b2 ~ R' }4 h" l* _4 n4 `
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Matrix Cells from Wharton’s Jelly Form Neurons and Glia |
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