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最近研究表明,以往认为不能再生的神经组织仍然包含神经干细胞, 而且神经干细胞有更大的可塑性和分化潜能,如:神经干细胞移植是修复神经功能受损的有效方法;它还可能作为一种“有前途的”脑癌治疗新手段,根除手术后残留的肿瘤;除此之外,神经干细胞的功能还可延伸到药物检测方面,对判断药物有效性、毒性有一定的作用。然而对神经干细胞的研究才刚刚起步,尚有许多关键性问题尚未解决。但我们相信不久的将来人类的神经干细胞将有望用于临床作为脑移植的供体细胞以及基因治疗的载体。而其增殖和定向诱导分化机制的最终阐明将有赖于分子生物学、发育生物学等生物学科的相互协作和研究方法的进一步完善。; N% U7 q# w. ]2 [- B
! A8 P) Q# }7 \7 e2 c) N( iIdentifying And Tracking Neural Stem Cells
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Marrow Stromal Cells, Mitosis, And Neuronal Differentiation-Stem Cell And Precursor Functions( I; J( @2 A9 X' o4 l. q
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Diclofenac Inhibits Proliferation And Differentiation Of Neural Stem Cells* S! h u; |; f$ {* x
) o8 Z5 ^! A! a: [5 q! KThe Stem-Cell Menagerie0 P3 \9 [0 P7 i
+ C) ?8 _$ l, R$ f- YNeural Progenitor Cells Lack Immunogenicity And Resist Destruction As Allografts L6 V8 W0 W, e" Q$ `/ H
9 r9 O) }5 S3 _3 F+ c7 uTranscriptional Profiling Of Neuronal Differentiation By Human Embryonal Carcinoma Stem Cells In Vitro9 o# j1 `! u' O
2 ^, c8 E2 c$ {- T3 k. r8 MRapid method for culturing embryonic neuron-glial cell cocultures5 c5 S( o7 k7 ]5 \
2 S$ c. d- H7 B- ^ bNeural stem cells and cholinergic neurons
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Identification and isolation of multipotential neural progenitor cells from human brain9 v& `; s' D/ R6 C
* ]8 Q3 A$ c+ M3 J& lTransplanted neuronal progenitor cells in a peripheral nerve gap promote nerve repair6 M" h: C% k7 S. B) z* q( e) f
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EGF-responsive rat neural stem cells
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Neural stem cells and neuro-oncology1 B# O- Z4 t. J$ N. w6 R' [$ F
, b: E! X( C$ t4 n ?1 ?- e7 tWhat are the characteristics of cycling cells in the adult central nervous system! H" B) e9 U" g+ w+ f! G4 l
9 Q+ K; a/ D; ?2 E% MSomatic plasticity of neural stem cells; C( }5 m# s& f' ~8 J* r# m
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Copernican stem cells-Regulatory constellations in adult hippocampal neurogenesis
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Neural stem cells in aging and disease
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0 K2 |& I/ Z3 NTransdifferentiation-fact or artifact
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# Z/ m. |8 ~" `# S: L' vIdentification and isolation of multipotential neural progenitor cells from the subcortical white matter of the adult human brain
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1 {7 b$ z9 x; I. {6 ]PTEN regulation of neural development and CNS stem cells' s" p& Q j' M
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Neural progenitor cells resist excitatory amino acid-induced neurotoxicity
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7 q ]' A4 [! g, BTumor suppressor gene BRCA-1 is expressed by embryonic and adult neural stem cells% Q+ j4 f! b0 Z9 q; R, J0 f$ R: l
9 q8 u$ r+ p2 O* Z3 i& ATransplanted bone marrow generates new neurons in human brains
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( v5 ^; D! P5 u& Q% B& pNeural stem cells and neuro-oncology
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: n6 A& I( \. F, iWhat are the characteristics of cycling cells in the adult central nervous system' w$ ~, w3 E& w0 n0 `4 b
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Neural stem cells
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PTEN regulation of neural development and CNS stem cells3 w, u0 I8 `/ H& S4 P1 O- j& N
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Somatic plasticity of neural stem cells
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Transdifferentiation-fact or artifact, f" N" \- l% b) s# n* p
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Copernican stem cells( E+ X/ X1 X, g8 o+ A1 F
: e, @5 k3 ^" y8 k4 bContribution of transplanted bone marrow cells to Purkinje neurons in human adult brains
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# D0 ?0 ^+ L) b& m" m0 C5 u4 ZSonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo
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Transplantation of neural stem cells in a rat model of stroke
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A Subset of ES-Cell-Derived Neural Cells Marked by Gene Targeting2 w; _4 { ~! S% b4 t: ?2 ~
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Matrix Cells from Wharton’s Jelly Form Neurons and Glia |
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